Long-Term Results with Adjuvant Ozone Therapy in the Management of Chronic Pelvic Pain Secondary to Cancer Treatment

Bernardino Clavo, Minerva Navarro, Mario Federico, Emma Borrelli, Ignacio J Jorge, Ivone Ribeiro, Juan I Rodríguez-Melcon, Miguel A Caramés, Norberto Santana-Rodríguez, Francisco Rodríguez-Esparragón, Bernardino Clavo, Minerva Navarro, Mario Federico, Emma Borrelli, Ignacio J Jorge, Ivone Ribeiro, Juan I Rodríguez-Melcon, Miguel A Caramés, Norberto Santana-Rodríguez, Francisco Rodríguez-Esparragón

No abstract available

Keywords: Cancer Pain; Cancer Survivorship; Chemotherapy-Induced Side Effects; Chronic Pelvic Pain; Neuropathic Pain; Ozone Therapy; Radiation-Induced Toxicity.

Figures

Figure 1
Figure 1
Clinical evolution of continuous and acute pelvic pain during and after ozone therapy. Pain levels according to the VAS. All but one of the patients showed clinically relevant improvement in pain levels after O3T. (A) Continuous pelvic pain. Initial continuous pelvic pain (7.8 ± 2.1) was significantly decreased after 3 months of O3T (P = 0.020) and at the end of O3T (P = 0.010). The benefit was maintained at 3 (P = 0.006), 6 (P = 0.006), and 9 (P = 0.006) months’ follow-up after the end of O3T. (B) Acute pelvic pain. Initial acute pelvic pain (8.6 ± 1.3) was significantly decreased in frequency at intensity after 3 months of O3T (P = 0.011) and at the end of O3T (P = 0.005). The benefit was maintained at 3 (P = 0.005), 6 (P = 0.005), and 9 (P = 0.005) months’ follow-up after the end of O3T.

References

    1. Clavo B, Navarro M, Federico M, et al. Ozone therapy in refractory pelvic pain syndromes secondary to cancer treatment: A new approach warranting exploration. J Palliat Med 2021;24(1):97–102.
    1. Paice JA, Portenoy R, Lacchetti C, et al.Management of chronic pain in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol 2016;34(27):3325–45.
    1. Bennett MI, Rayment C, Hjermstad M, et al.Prevalence and aetiology of neuropathic pain in cancer patients: A systematic review. Pain 2012;153(2):359–65.
    1. Clavo B, Ceballos D, Gutierrez D, et al.Long-term control of refractory hemorrhagic radiation proctitis with ozone therapy. J Pain Symptom Manage 2013;46(1):106–12.
    1. Clavo B, Rodriguez-Esparragon F, Rodriguez-Abreu D, et al.Modulation of oxidative stress by ozone therapy in the prevention and treatment of chemotherapy-induced toxicity: Review and prospects. Antioxidants (Basel) 2019;8(12):588.

Source: PubMed

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