Pharmacological Effects and Underlying Mechanisms of Licorice-Derived Flavonoids

Yufan Wu, Zhuxian Wang, Qunqun Du, Zhaoming Zhu, Tingting Chen, Yaqi Xue, Yuan Wang, Quanfu Zeng, Chunyan Shen, Cuiping Jiang, Li Liu, Hongxia Zhu, Qiang Liu, Yufan Wu, Zhuxian Wang, Qunqun Du, Zhaoming Zhu, Tingting Chen, Yaqi Xue, Yuan Wang, Quanfu Zeng, Chunyan Shen, Cuiping Jiang, Li Liu, Hongxia Zhu, Qiang Liu

Abstract

Glycyrrhizae Radix et Rhizoma is the most frequently prescribed natural medicine in China and has been used for more than 2,000 years. The flavonoids of licorice have garnered considerable attention in recent decades due to their structural diversity and myriad pharmacological effects, especially as novel therapeutic agents against inflammation and cancer. Although many articles have been published to summarize different pharmacological activities of licorice in recent years, the systematic summary for flavonoid components is not comprehensive. Therefore, in this review, we summarized the pharmacological and mechanistic data from recent researches on licorice flavonoids and their bioactive components.

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Copyright © 2022 Yufan Wu et al.

Figures

Figure 1
Figure 1
Pharmacological activities of licorice flavonoids.
Figure 2
Figure 2
(a) Flavanone, flavone, flavonol, and chalcone structure from licorice. (b) Isoflavone, isoflavanone, isoflavan, and isoflavene structure from licorice.
Figure 3
Figure 3
The main signaling pathway of anti-inflammation of licorice flavonoids.
Figure 4
Figure 4
The main antitumor signaling pathway of licorice flavonoids.

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Source: PubMed

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