Necrotizing enterocolitis: treatment based on staging criteria

M C Walsh, R M Kliegman, M C Walsh, R M Kliegman

Abstract

Neonatal necrotizing enterocolitis is the most important cause of acquired gastrointestinal morbidity or mortality among low birthweight infants. Prematurity alone is probably the only identifiable risk factor. Although the etiology is unknown NEC has many similarities to an infectious disease. Proper staging helps improve reporting and the management of NEC.

References

    1. Abbasi S. Long-term assessment of growth, nutritional status, and gastrointestinal function in survivors of NEC. J. Pediatr. 1984;104:550.
    1. Anderson C., Collin M., Okeefe J. A widespread epidemic of mild necrotizing enterocolitis of unknown cause. Am. J. Dis. Child. 1984;138:979.
    1. Anderson D.M., Rome E.S., Kliegman R.M. Relationship of endemic necrotizing enterocolitis to alimentation. Pediatr. Res. 1985;19:331A.
    1. Anysley-Green A., Adrian T.E., Bloom S.R. Feeding and the development of enteroinsular hormone release in the preterm infant: Effects of continuous gastric infusion compared with intermittent boluses. Acta Pediatr. Scand. 1982;71:379.
    1. Anysley-Green A. Hormones and postnatal adaptation to enteral nutrition. J. Pediatr. Gastroenterol. Nutr. 1983;2:418.
    1. Aziz E.M. Neonatal pneumatosis intestinalis associated with milk intolerance. Am. J. Dis. Child. 1973;125:560.
    1. Bantley V.E., Hiah I.M., Hegy T. The effectiveness of oral gentamicin in reducing NEC in treated and control infants. Pediatr. Res. 1980;14:592.
    1. Bell M.J., Kosloske A.M., Benton C. Neonatal necrotizing enterocolitis: Prevention of perforation. J. Pediatr. Surg. 1973;8:601.
    1. Bell M.J., Ternberg J.L., Feigin R.D. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann. Surg. 1978;187:1.
    1. Benirschke K. Report of 68th Ross Conference on Pediatric Research. Vol. 27. Ross Labs; Columbus, OH: 1974. Necrotizing enterocolitis in the newborn infant.
    1. Benner J., Polley T., Strodel W. Fluid resuscitation in live Escherichia coli shock in puppies. J. Pediatr. Surg. 1980;15:527.
    1. Black V., Lubchenco L.O., Koops B.L. Neonatal hyperviscosity: Randomized study of partial plasma exchange in altering long-term outcome. Pediatr. Res. 1982;16:279A.
    1. Book L.S., Herbst J.J., Jung A.L. Necrotizing entericolitis in infants fed an elemental formula. J. Pediatr. 1975;87:602.
    1. Book L.S., Herbst J.J., Jung A.L. Comparison of fast- and slow-feeding rate schedules to the development of NEC. J. Pediatr. 1976;89:463.
    1. Book L.S., Overall J.C., Herbst J. Clustering of necrotizing enterocolitis: Interruption by infection control measures. N. Engl. J. Med. 1977;297:984.
    1. Brown E.G., Sweet A.Y. Preventing necrotizing enterocolitis in neonates. JAMA. 1978;240:2452.
    1. Brown E.G., Sweet A.Y. Neonatal necrotizing enterocolitis. Pediatr. Clin. North Am. 1982;29:1149.
    1. Buntain W.L., Connet E., Emrico J. Transcutaneous oxygen (TcPO2) measurement as an aid to fluid therapy in necrotizing enterocolitis. J. Pediatr. Surg. 1979;14:728.
    1. Bunton G.L., Durbin G.M., McIntosh N. Necrotizing enterocolitis: Controlled study of 3-years’ experience in an NICU. Arch. Dis. Child. 1972;52:772.
    1. Cashore W.J., Peter G., Lanermann M. Clostridia colonization and clostridia toxin in neonatal necrotizing enterocolitis. J. Pediatr. 1981;98:308.
    1. Chany C., Moscovici O., Lebon P. Association of coronavirus infection with neonatal necrotizing enterocolitis. Pediatrics. 1982;69:209.
    1. Christensen R.D., Rothstein G., Anstall H.B. Granulocyte transfusion in neonates. Pediatrics. 1982;70:1.
    1. Conta S.T., Myers M.G. Clostridium difficile toxin in asymptomatic neonates. J. Pediatr. 1982;100:431.
    1. Costin B.S., Singleton E.B. Bowel stenosis as a late complication of acute necrotizing enterocolitis. Radiology. 1978;128:435.
    1. Cushing H.A. Necrotizing enterocolitis with E. coli: Heat labile enterotoxin. Pediatrics. 1983;71:626.
    1. Editorial: Clostridia as intestinal pathogens. Lancet. 1977;2:1113.
    1. Editorial: Lengthening of baby gut. Lancet. 1985;1:440.
    1. Egan E.A., Mantilla G., Nelson R.M. A prospective controlled trial of oral kanamycin in the prevention of neonatal necrotizing enterocolitis. J. Pediatr. 1976;89:467.
    1. Engel R.R., Viring N.L., Hunt C.E. Origin of mural gas in necrotizing enterocolitis. Pediatr. Res. 1973;7:292.
    1. Engel R.R. Ross Labs; Columbus OH: 1974. Necrotizing enterocolitis in the newborn: Report of the 68th Ross Conference on Pediatric Research.
    1. Eyal F., Sagi E., Arad I. Necrotizing enterocolitis in the very low birthweight infant: Expressed breast milk feeding compared with parental feeding. Arch. Dis. Child. 1982;57:246.
    1. Frantz I.D., L’Heureux P., Engel R.R. Necrotizing enterocolitis. J. Pediatr. 1975;86:259.
    1. Garcia J., Smith F.R., Cucinelli S.A. Urinary D-lactate excretion in infants with necrotizing enterocolitis. J. Pediatr. 1984;104:268.
    1. Goldman H.I. Feeding and necrotizing enterocolitis. Am. J. Dis. Child. 1980;134:553.
    1. Gotaff S.P. Neonatal immunity. J. Pediatr. 1974;85:149.
    1. Grylack L.J., Scanlon J.W. Oral gentamicin therapy in the prevention of neonatal necrotizing enterocolitis. Am. J. Dis. Child. 1978;132:1192.
    1. Hack M. NEC in the very low birthweight: An encouraging follow-up report. Pediatr. Res. 1981;15:534.
    1. Han V.M., Sayed H., Chance G.W. An outbreak of Clostridium difficile necrotizing enterocolitis: A case for oral vancomycin therapy? Pediatrics. 1983;71:935.
    1. Hansen T.N., Ritter D.A., Speer M.E. A randomized controlled study of oral gentamicin in the treatment of neonatal necrotizing enterocolitis. J. Pediatr. 1980;97:836.
    1. Head J.R. Immunobiology of lactation. Semin. Perinatol. 1977;1:195.
    1. Henderson A., Maclaurin J., Scott J.M. Pseudomonas in a Glascow baby unit. Lancet. 1969;2:316.
    1. Hill H.R., Hunt C.E., Matsen J.M. Nosocomial colonization with Klebsiella type 26. J. Pediatr. 1974;85:415.
    1. Howard F.M., Flynn D.M., Bradley J.M. Outbreak of necrotizing enterocolitis caused by C. butyricum. Lancet. 1977;2:1099.
    1. Joshi V.V., Draper D.A., Bates R.D. Neonatal necrotizing enterocolitis: Occurrence secondary to thrombosis of abdominal aorta following umbilical arterial catheterization. Arch. Pathol. 1975;99:540.
    1. Joshi V.V. Implications of pathologic findings in the treatment of neonatal necrotizing enterocolitis. Pediatrics. 1977;59:954.
    1. Kirschner B.S., Lahr C., Lahr D. Detection of increased breath hydrogen in infants with necrotizing enterocolitis. Gastroenterology. 1977;72:A57/1080.
    1. Kliegman R.M. Neonatal necrotizing enterocolitis: Implications for an infectious disease. Pediatr. Clin. North Am. 1979;26:327.
    1. Kliegman R.M., Fanaroff A.A. Neonatal necrotizing enterocolitis: A nine-year experience. Epidemiology and uncommon observations. Am. J. Dis. Child. 1981;135:603.
    1. Kliegman R.M., Fanaroff A.A. Necrotizing enterocolitis. N. Engl. J. Med. 1984;310:1093.
    1. Kliegman R.M., Hack M., Jones P. Epidemiologic study of necrotizing enterocolitis among low birthweight infants. J. Pediatr. 1982;100:440.
    1. Kliegman R.M., Pittard W.B., Fanaroff A.A. Necrotizing enterocolitis in neonates fed human milk. J. Pediatr. 1979;95:450.
    1. Kliegman R., Stork E., Fanaroff A.A. Lack of relationship between umbilical arterial catheter complications and necrotizing enterocolitis. Pediatr. Res. 1985;19:349A.
    1. Kosloske A.M. Pathogenesis and prevention of necrotizing enterocolitis: A hypothesis. Pediatrics. 1984;74:1086.
    1. Kosloske A.M., Goldthorn J. Paracentesis as an aid to the diagnosis of intestinal gangrene. Arch. Surg. 1982;117:571.
    1. Lake A.M., Lauret B.A., Clark J.C. Enteroviral infections in neonates. J. Pediatr. 1976;89:787.
    1. Lawrence G., Bates J., Gal A. Pathogenesis of necrotizing enterocolitis. Lancet. 1982;1:137.
    1. Lawrence G., Walker P.D. Pathogenesis of enteritis necroticans in Papua New Guinea. Lancet. 1976;1:125.
    1. Leake R.D., Thanopoulos B., Nieberg R. Hyperviscosity syndrome associated with necrotizing enterocolitis. Am. J. Dis. Child. 1975;129:1192.
    1. LeBlanc M.H., D’Cruz C., Pate K. Necrotizing enterocolitis can be caused by polycythemic hyperviscosity in the newborn dog. J. Pediatr. 1984;105:804.
    1. Lehmiller D.J., Kanto W.P., Jr. Relationships of mesenteric thromboembolism, oral feeding, and necrotizing enterocolitis. J. Pediatr. 1978;92:96.
    1. Leonidas J.C., Hall R.T. Neonatal pneumatosis coli: A mild form of neonatal necrotizing enterocolitis. J. Pediatr. 1976;89:456.
    1. Lucas A., Bloom S.R., Aynsley-Green A. Postnatal surges in plasma gut hormones in term and preterm infants. Biol. Neonate. 1982;41:63.
    1. Malin S.W., Bhutani V.K., Ritchie W.W. Echogenic intravascular and hepatic microbubbles associated with necrotizing enterocolitis. J. Pediatr. 1983;103:637.
    1. Marchildon M.B., Buck B.E., Adenour G. Necrotizing enterocolitis in the unfed infant. J. Pediatr. Surg. 1982;17:620.
    1. Merritt C., Goldsmith J., Sharp M. Sonographic detection of portal venous gas in infants with necrotizing enterocolitis. Am. J. Radiol. 1984;143:1059.
    1. Moomjian A., Peckham G., Fox W. Necrotizing enterocolitis endemic vs. epidemic form. Pediatr. Res. 1978;12:530.
    1. Moriartey R.R., Finer N.N., Cox S.F. Necrotizing enterocolitis and human milk. J. Pediatr. 1979;94:295.
    1. O’Neill J.A., Stahlman M.T., Meng H.C. Necrotizing enterocolitis in the newborn: Operative indications. Ann. Surg. 1975;182:274.
    1. Polin R.A., Pollack P.F., Barlow B. Necrotizing enterocolitis in term infants. J. Pediatr. 1976;89:460.
    1. Powell G.K. Enterocolitis in low birthweight infants associated with milk and soy protein intolerance. J. Pediatr. 1976;88:840.
    1. Powell J., Burean M., Pare C. Necrotizing enterocolitis: Epidemic following an outbreak of enterobacter cloace type 3305573 in an NICU. Am. J. Dis. Child. 1980;134:1152.
    1. Reisner S.H., Gary B. Necrotizing enterocolitis despite breastfeeding. Lancet. 1977;2:507.
    1. Richmond J.A., Mikity V. Benign form of necrotizing enterocolitis. Am. J. Roentgenol. Radium Ther. Nucl. Med. 1975;123:301.
    1. Roback S.A., Foker J., Frantz I.F. Necrotizing enterocolitis. Arch. Surg. 1974;109:314.
    1. Robertson D.M., Paganelli R., Dinwiddie R., Levinsky R.J. Milk antigen absorption in the preterm and term neonate. Arch. Dis. Child. 1982;57:369.
    1. Rotbart H.A., Levin M.J. How contagious is necrotizing enterocolitis? Pediatr. Infect. Dis. 1983;2:406.
    1. Rotbart H.A., Levin M.J., Yolken R.H. An outbreak of rotavirus-associated neonatal necrotizing enterocolitis. J. Pediatr. 1983;103:454.
    1. Rothstein F.C., Halpin T.C., Kliegman R.M. Importance of early ileostomy closure to prevent chronic salt and water losses after necrotizing enterocolitis. Pediatrics. 1982;70:249.
    1. Rousett S., Moscovici O., Lebon P. Intestinal lesions containing coronavirus like particles in neonatal necrotizing enterocolitis: An ultrastructural analysis. Pediatrics. 1984;73:218.
    1. Ryder R.W., Shelton J.D., Guinan M.E. Necrotizing enterocolitis: A prospective multicenter investigation. Am. J. Epidemiol. 1980;112:113.
    1. Santulli T.V., Schullinger J.N., Heird W.C. Acute necrotizing enterocolitis in infancy: A review of 64 cases. Pediatrics. 1975;55:376.
    1. Sheretz R.J., Sarubbi F.A. The prevalence of Clostridium difficile and toxin in a nursery population: A comparison between patients with necrotizing enterocolitis and an asymptomatic group. J. Pediatr. 1982;100:435.
    1. Speer M.E., Taber L.H., Yow M.D. Fulminant neonatal sepsis and necrotizing enterocolitis associated with a “nonenteropathogenic” strain of E. coli. J. Pediatr. 1976;89:91.
    1. Stein H., Bek J., Solomon A. Gastroenteritis with necrotizing enterocolitis in premature babies. Br. Med. J. 1972;2:616.
    1. Stoll B.J., Kanto W.P., Jr., Glass R.I. Epidemiology of necrotizing enterocolitis: A case control study. J. Pediatr. 1980;96:447.
    1. Thilo E.H., Lazarate R.A., Hernandez J.A. Necrotizing enterocolitis in the first 24 hours of life. Pediatrics. 1984;73:476.
    1. Tilson M.D. Pathophysiology and treatment of short bowel syndrome. Surg. Clin. North Am. 1980;60:1273.
    1. Touloukian R.J., Posch J.N., Spencer R. The pathogenesis of ischemic gastroenterocolitis of the neonate: Selective gut mucosal ischemia in asphyxiated neonatal piglets. J. Pediatr. Surg. 1972;7:194.
    1. Waldhausen J.A., Herendeen T., King H. Necrotizing colitis of the newborn: Common cause of perforation of the colon. Pediatr. Surg. 1963;54:365.
    1. Walsh M.C., Simpser E. Late onset sepsis in infants with bowel resection. Pediatr. Res. 1985;19:210A.
    1. Welch D.F., Marks M.I. Is Clostridium difficile pathogenic in infants? J. Pediatr. 1982;100:393.
    1. Willis D.M., Chabot J., Radde I.C. Unsuspected hyperosmolality of oral solutions contributing to necrotizing enterocolitis in very low birthweight infants. Pediatrics. 1977;60:535.
    1. Wilson R., del Portillo M., Schmidt E. Risk factors for necrotizing enterocolitis in infants weighing more than 2,000 grams at birth: A case control study. Pediatrics. 1983;71:19.
    1. Yale C.E., Balish E. Intestinal strangulation in germ-free and monocontaminated dogs. Arch. Surg. 1979;114:445.
    1. Yolken R., Franklin C. Gastrointestinal adenovirus: An important cause of morbidity in patients with necrotizing enterocolitis and gastrointestinal surgery. Pediatr. Infect. Dis. 1985;4:42.
    1. Yu V.Y., Tudehope D.I. Neonatal necrotizing enterocolitis II. Perinatal risk factors. Med. J. Austr. 1977;1:688.

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