Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: successful engraftment and mild GVHD
Yamei Wu, Yongbin Cao, Xiaohong Li, Lixin Xu, Zhihong Wang, Pei Liu, Pei Yan, Zhouyang Liu, Jing Wang, Shuang Jiang, Xiaoxiong Wu, Chunji Gao, Wanming Da, Zhongchao Han, Yamei Wu, Yongbin Cao, Xiaohong Li, Lixin Xu, Zhihong Wang, Pei Liu, Pei Yan, Zhouyang Liu, Jing Wang, Shuang Jiang, Xiaoxiong Wu, Chunji Gao, Wanming Da, Zhongchao Han
Abstract
Haploidentical hematopoietic stem-cell transplantation (haplo-HSCT) is associated with an increased risk of graft failure and severe graft-versus-host disease (GVHD). Mesenchymal stromal cells (MSCs) have been shown to support in vivo normal hematopoiesis and to display potent immunesuppressive effects. We cotransplanted the culture-expanded third-party donor-derived umbilical cord MSCs (UC-MSCs) in 21 young people with severe aplastic anemia (SAA) undergoing haplo-HSCT without T-cell-depleted. We observed that all patients had sustained hematopoietic engraftment without any adverse UC-MSC infusion-related events. Furthermore, we did not observe any increase in severe aGVHD. These data suggest that UC-MSCs, possibly thanks to their potent immunosuppressive effect on allo-reactive host T lymphocytes escaping the preparative regimen, reduce the risk of graft failure and severe GVHD in haplo-HSCT.
© 2013.
Source: PubMed