An unsupported preference for intravenous antibiotics

Ho Kwong Li, Ambrose Agweyu, Mike English, Philip Bejon, Ho Kwong Li, Ambrose Agweyu, Mike English, Philip Bejon

Abstract

Philip Bejon and colleagues reflect on the widespread belief in the superiority of intravenous antibiotics.

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1. Forest plot for trials comparing…
Fig 1. Forest plot for trials comparing treatment failure among children in low-income settings who were treated with amoxicillin or benzyl penicillin for severe pneumonia.
See supplementary figure 2 of [19].

References

    1. Boyles TH, Whitelaw A, Bamford C, Moodley M, Bonorchis K, Morris V, et al. Antibiotic stewardship ward rounds and a dedicated prescription chart reduce antibiotic consumption and pharmacy costs without affecting inpatient mortality or re-admission rates. PLoS One. 2013;8: e79747 10.1371/journal.pone.0079747
    1. Dellit TH, Owens RC, McGowan JE Jr., Gerding DN, Weinstein RA, Burke JP, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007;44: 159–177.
    1. Carreazo NY, Bada CA, Chalco JP, Huicho. Audit of therapeutic interventions in inpatient children using two scores: are they evidence-based in developing countries? BMC Health Serv Res. 2004;4: 40
    1. Maki DG, Kluger DM, Crnich CJ. The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies. Mayo Clin Proc. 2006;81: 1159–1171.
    1. Edgeworth J. Intravascular catheter infections. J Hosp Infect. 2009;73: 323–330. 10.1016/j.jhin.2009.05.008
    1. Aiken AM, Mturi N, Njuguna P, Mohammed S, Berkley JA, Mwangi I, et al. Risk and causes of paediatric hospital-acquired bacteraemia in Kilifi District Hospital, Kenya: a prospective cohort study. Lancet. 2011;378: 2021–2027. 10.1016/S0140-6736(11)61622-X
    1. Chapman AL, Dixon S, Andrews D, Lillie PJ, Bazaz R, Patchett JD. Clinical efficacy and cost-effectiveness of outpatient parenteral antibiotic therapy (OPAT): a UK perspective. J Antimicrob Chemother. 2009;64: 1316–1324. 10.1093/jac/dkp343
    1. Levy MM, Artigas A, Phillips GS, Rhodes A, Beale R, Osborn T, et al. Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis. 2012;12: 919–924. 10.1016/S1473-3099(12)70239-6
    1. Karageorgopoulos DE, Valkimadi PE, Kapaskelis A, Rafailidis PI, Falagas ME. Short versus long duration of antibiotic therapy for bacterial meningitis: a meta-analysis of randomised controlled trials in children. Arch Dis Child. 2009;94: 607–614. 10.1136/adc.2008.151563
    1. World-Health-Organisation. Pocket book of hospital care for children: guidelines for the management of common illnesses with limited resources. Geneva: World-Health-Organisation; 2013.
    1. Lim WS, Baudouin SV, George RC, Hill AT, Jamieson C, Le Jeune I, et al. BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax 64 2009; Suppl.3: iii1–55. 10.1136/thx.2009.121434
    1. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 44 2007; Suppl.2: S27–72.
    1. Vogelman B, Gudmundsson S, Leggett J, Turnidge J, Ebert S, Craig WA. Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model. J Infect Dis. 1988;158: 831–847.
    1. Saivin S, Houin G. Clinical pharmacokinetics of doxycycline and minocycline. Clin Pharmacokinet. 1988;15: 355–366.
    1. Bouazza N, Pestre V, Jullien V, Curis E, Urien S, Salmon D, et al. Population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitis. Br J Clin Pharmacol. 2012;74: 971–977. 10.1111/j.1365-2125.2012.04292.x
    1. Arancibia A, Guttmann J, Gonzalez G, Gonzalez C. Absorption and disposition kinetics of amoxicillin in normal human subjects. Antimicrob Agents Chemother. 1980;17: 199–202.
    1. Hazir T, Fox LM, Nisar YB, Fox MP, Ashraf YP, MacLeod WB, et al. Ambulatory short-course high-dose oral amoxicillin for treatment of severe pneumonia in children: a randomised equivalency trial. Lancet. 2008;371: 49–56. 10.1016/S0140-6736(08)60071-9
    1. Addo-Yobo E, Chisaka N, Hassan M, Hibberd P, Lozano JM, Jeena P, et al. Oral amoxicillin versus injectable penicillin for severe pneumonia in children aged 3 to 59 months: a randomised multicentre equivalency study. Lancet. 2004;364: 1141–1148.
    1. Agweyu A, Gathara D, Oliwa J, Muinga N, Edwards T, Allen E, et al. Oral Amoxicillin Versus Benzyl Penicillin for Severe Pneumonia Among Kenyan Children: A Pragmatic Randomized Controlled Noninferiority Trial. Clin Infect Dis. 2014;60(8): 1216–1224. 10.1093/cid/ciu1166
    1. Atkinson M, Lakhanpaul M, Smyth A, Vyas H, Weston V, Sithole J, et al. Comparison of oral amoxicillin and intravenous benzyl penicillin for community acquired pneumonia in children (PIVOT trial): a multicentre pragmatic randomised controlled equivalence trial. Thorax. 2007;62: 1102–1106.
    1. Siegel RE, Halpern NA, Almenoff PL, Lee A, Cashin R, Greene JG. A prospective randomized study of inpatient iv. antibiotics for community-acquired pneumonia. The optimal duration of therapy. Chest. 1996;110: 965–971.
    1. Oosterheert JJ, Bonten MJ, Schneider MM, Buskens E, Lammers JW, Hustinx WM, et al. Effectiveness of early switch from intravenous to oral antibiotics in severe community acquired pneumonia: multicentre randomised trial. BMJ. 2006;333: 1193
    1. Castro-Guardiola A, Viejo-Rodriguez AL, Soler-Simon S, Armengou-Arxe A, Bisbe-Company V, Penarroja-Matutano G, et al. Efficacy and safety of oral and early-switch therapy for community-acquired pneumonia: a randomized controlled trial. Am J Med. 2001;111: 367–374.
    1. Vogel F, Lode H. The use of oral temafloxacin compared with a parenteral cephalosporin in hospitalized patients with pneumonia. J Antimicrob Chemother. 1991;28 Suppl C: 81–86.
    1. Strohmeier Y, Hodson EM, Willis NS, Webster AC, Craig JC. Antibiotics for acute pyelonephritis in children. Cochrane Database Syst Rev. 2014;7: CD003772 10.1002/14651858.CD003772.pub4
    1. Vidal L, Ben Dor I, Paul M, Eliakim-Raz N, Pokroy E, Soares-Weiser K, et al. Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients. Cochrane Database Syst Rev. 2013;10: CD003992 10.1002/14651858.CD003992.pub3
    1. Heldman AW, Hartert TV, Ray SC, Daoud EG, Kowalski TE, Pompili VJ, et al. Oral antibiotic treatment of right-sided staphylococcal endocarditis in injection drug users: prospective randomized comparison with parenteral therapy. Am J Med. 1996;101: 68–76.
    1. Conterno LO, Turchi MD. Antibiotics for treating chronic osteomyelitis in adults. Cochrane Database Syst Rev. 2013;9: CD004439 10.1002/14651858.CD004439.pub3
    1. Zaoutis T, Localio AR, Leckerman K, Saddlemire S, Bertoch D, Keren R. Prolonged intravenous therapy versus early transition to oral antimicrobial therapy for acute osteomyelitis in children. Pediatrics. 2009;123: 636–642. 10.1542/peds.2008-0596
    1. Keren R, Shah SS, Srivastava R, Rangel S, Bendel-Stenzel M, Harik N, et al. Comparative Effectiveness of Intravenous vs Oral Antibiotics for Postdischarge Treatment of Acute Osteomyelitis in Children. JAMA Pediatr. 2015;169: 120–128. 10.1001/jamapediatrics.2014.2822
    1. Group AFNST. Treatment of fast breathing in neonates and young infants with oral amoxicillin compared with penicillin-gentamicin combination: study protocol for a randomized, open-label equivalence trial. Pediatr Infect Dis J 32 2013; Suppl.1: S33–38. 10.1097/INF.0b013e31829ff7eb
    1. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (2015) Oral Versus Intravenous Antibiotics (OVIVA) for Bone and Joint Infection. .
    1. Fletcher C. First clinical use of penicillin. Br Med J (Clin Res Ed). 1984;289: 1721–1723.
    1. Brandt AM. No Magic Bullet, A social history of venereal disease in the United States since 1880. Oxford: Oxford University Press, 1985.
    1. Finniss DG, Kaptchuk TJ, Miller F, Benedetti F. Biological, clinical, and ethical advances of placebo effects. Lancet. 2010;375: 686–695. 10.1016/S0140-6736(09)61706-2
    1. Engel MF, Postma DF, Hulscher ME, Teding van Berkhout F, Emmelot-Vonk MH, Sankatsing S, et al. Barriers to an early switch from intravenous to oral antibiotic therapy in hospitalised patients with CAP. Eur Respir J. 2013;41: 123–130. 10.1183/09031936.00029412

Source: PubMed

3
Abonnieren