Pulmonary metastasectomy for sarcoma: a systematic review of reported outcomes in the context of Thames Cancer Registry data

Tom Treasure, Francesca Fiorentino, Marco Scarci, Henrik Møller, Martin Utley, Tom Treasure, Francesca Fiorentino, Marco Scarci, Henrik Møller, Martin Utley

Abstract

Objectives: Sarcoma has a predilection to metastasis to the lungs. Surgical excision of these metastases (pulmonary metastasectomy) when possible has become standard practice. We reviewed the published selection and outcome data.

Design: Systematic review of published reports that include survival rates or any other outcome data. Survival data were put in the context of those in a cancer registry.

Setting: Specialist thoracic surgical centres reporting the selection and outcome for pulmonary metastasectomy in 18 follow-up studies published 1991-2010.

Participants: Patients having one or more of 1357 pulmonary metastasectomy operations performed between 1980 and 2006.

Interventions: All patients had surgical pulmonary metastasectomy. A first operation was reported in 1196 patients. Of 1357 patients, 43% had subsequent metastasectomy, some having 10 or more thoracotomies. Three studies were confined to patients having repeated pulmonary metastasectomy.

Primary and secondary outcome measures: Survival data to various time points usually 5 years and sometimes 3 or 10 years. No symptomatic or quality of life data were reported.

Results: About 34% and 25% of patients were alive 5 years after a first metastasectomy operation for bone or soft tissues sarcoma respectively. Better survival was reported with fewer metastases and longer intervals between diagnosis and the appearance of metastases. In the Thames Cancer Registry for 1985-1994 and 1995-2004 5 year survival rates for all patients with metastatic sarcoma were 20% and 25% for bone, and for soft tissue sarcoma 13% and 15%.

Conclusions: The 5 year survival rate among sarcoma patients who are selected to have pulmonary metastasectomy is higher than that observed among unselected registry data for patients with any metastatic disease at diagnosis. There is no evidence that survival difference is attributable to metastasectomy. No data were found on respiratory or any other symptomatic benefit. Given the certain harm associated with thoracotomy, often repeated, better evidence is required.

Figures

Figure 1
Figure 1
Thames Cancer Registry data. Kaplan Meier survival plots by stage for decades 1985–1994 (above) and 1995–2004 (below) for bone (left) and soft tissue sarcoma (right). Stage 4 (ie, metastasised at the time of diagnosis/registration) in red.
Figure 2
Figure 2
Five-year survival rates plotted against the publication date.
Figure 3
Figure 3
Five-year survival rates plotted against the size of the series.
Figure 4
Figure 4
Three-year and 5-year survival rates from publications in table 6 (bone sarcoma red, soft tissue sarcoma green and mixed series blue).
Figure 5
Figure 5
The full display of essential features of the patients and their survival from primary resection to metastasectomy and subsequently. From Martini et al.
Figure 6
Figure 6
A conservative estimate of natural 5-year survivors is set at 5% (15/300 in this depiction) and they are in green. Ranking patients on the Y and X axes from least to most favourable based on fewer metastases and longer interval since diagnosis might have the effect of clustering these natural survivors as shown. If selection for surgery is also based on these factors, it might be the selection rather than the surgery which is associated with a higher than anticipated survival rate shown here as 10/25 or 40%.

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