Motor-skill learning in Alzheimer's disease: a review with an eye to the clinical practice

Ilse A D A van Halteren-van Tilborg, Erik J A Scherder, Wouter Hulstijn, Ilse A D A van Halteren-van Tilborg, Erik J A Scherder, Wouter Hulstijn

Abstract

Since elderly people suffering from dementia want to go on living independently for as long as possible, they need to be able to maintain familiar and learn new practical skills. Although explicit or declarative learning methods are mostly used to train new skills, it is hypothesized that implicit or procedural techniques may be more effective in this population. The present review discusses 23 experimental studies on implicit motor-skill learning in patients with Alzheimer's disease (AD). All studies found intact implicit motor-learning capacities. Subsequently, it is elaborated how these intact learning abilities can be exploited in the patients' rehabilitation with respect to the variables 'practice' and 'feedback.' Recommendations for future research are provided, and it is concluded that if training programs are adjusted to specific needs and abilities, older people with AD are well able to (re)learn practical motor skills, which may enhance their autonomy.

References

    1. None
    2. Baddeley, A. (1993). A theory of rehabilitation without a model of learning is a vehicle without an engine: A comment on Caramazza and Hillis. Neuropsychological Rehabilitation, 3(3), 235–244.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '7794479', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/7794479/'}]}
    2. Beatty, W. W., Scott, J. G., Wilson, D. A., Prince, R. J., & Williamson, D. J. (1995). Memory deficits in a demented patient with probable corticobasal degeneration. Journal of Geriatric Psychiatry and Neurology, 8, 132–137.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1097/00002093-200607000-00005', 'is_inner': False, 'url': 'https://doi.org/10.1097/00002093-200607000-00005'}, {'type': 'PubMed', 'value': '16917184', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/16917184/'}]}
    2. Becker, M., Andel, R., Rohrer, L., & Banks, S. M. (2006). The effect of cholinesterase inhibitors on risk of nursing home placement among Medicaid beneficiaries with dementia. Alzheimer’s disease and Associated Disorders, 20(3), 147–152.
    1. Birks, J., Grimley Evans, J., & Iakovidou, V. (2002). Rivastigmine for Alzheimer’s disease (Cochrane Review). In: The Cochrane Library, Issue 4. Oxford: updat Software.
    1. None
    2. Buchner, A., & Wippich, W. (1998). Differences and commonalities between implicit learning and implicit memory. In M. A. Stadler & P. A. Frensch (Eds.), Handbook of implicit learning. Thousand Oaks, CA.: Sage Publications.
    1. None
    2. Clare, L. (2003). Rehabilitation for people with dementia. In B. A. Wilson (Ed.), Neuropsychological rehabilitation, theory and practice. Lisse: Swets & Zeitlinger B.V.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1002/gps.428', 'is_inner': False, 'url': 'https://doi.org/10.1002/gps.428'}, {'type': 'PubMed', 'value': '11536347', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/11536347/'}]}
    2. De Vreese, L. P., Neri, M. Fioravanti, M., Belloi, L., & Zanetti, O. (2001). Memory rehabilitation in Alzheimer’s disease: A review of progress. International Journal of Geriatric Psychiatry, 16, 794–809.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '8004981', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/8004981/'}]}
    2. Deweer, B., Ergis, A. M., Fosatti, P., Pillon, B., Boller, F., Agid, Y., et al. (1994). Explicit memory, procedural learning and lexical priming in Alzheimer’s disease. Cortex, 30, 113–126.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1159/000075560', 'is_inner': False, 'url': 'https://doi.org/10.1159/000075560'}, {'type': 'PubMed', 'value': '14963376', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/14963376/'}]}
    2. De Winter, L. J. M., Hoyng, C. B., Froeling, P. G. A. M., Meulendijks, C. F. M., & van der Wilt, G. (2004). Prevalence of remediable disability due to low vision among institutionalised elderly people. Gerontology, 50, 96–101.
    1. None
    2. Dick, M. B., Andel, R., Bricker, J., Gorospe, J. B., Hsieh, S., & Dick-Muehlke, C. (2001). Dependence on visual feedback during motor skill learning in Alzheimer’s disease. Aging, Neuropsychology and Cognition, 8(2), 120–136.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1037/0894-4105.17.2.202', 'is_inner': False, 'url': 'https://doi.org/10.1037/0894-4105.17.2.202'}, {'type': 'PubMed', 'value': '12803425', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/12803425/'}]}
    2. Dick, M. B., Hsieh, S., Bricker, J., & Dick-Muelhlke, C. (2003). Facilitating acquisition of a continuous motor task in healthy older adults and patients with Alzheimer’s disease. Neuropsychology, 17(2), 202–212.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1006/brcg.2000.1206', 'is_inner': False, 'url': 'https://doi.org/10.1006/brcg.2000.1206'}, {'type': 'PubMed', 'value': '11104538', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/11104538/'}]}
    2. Dick, M. B., Hsieh, S., Dick-Muehlke, C., Davis, D. S. & Cotman, C. W. (2000). The variability of practice hypothesis in motor learning: Does it apply to Alzheimer’s disease? Brain and Cognition, 44, 470–489.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '3418039', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/3418039/'}]}
    2. Dick, M. B., Kean, M-L., & Sands, D. (1988).The preselection effect on the recall facilitation of motor movements in Alzheimer-type dementia. Journal of Gerontology: Psychological Sciences, 43, 127–135.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1006/brcg.1995.1283', 'is_inner': False, 'url': 'https://doi.org/10.1006/brcg.1995.1283'}, {'type': 'PubMed', 'value': '8838387', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/8838387/'}]}
    2. Dick, M. B., Nielson, K. A., Beth, R. B., Shankle, W. R., & Cotman, C. W. (1995). Acquisition and long-term retention of a fine motor skill an Alzheimer’s disease. Brain and Cognition, 29, 294—306.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '8785686', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/8785686/'}]}
    2. Dick, M. B., Shankle, R. W., Beth, R. E., Dick-Muehlke, C., Cotman, C. W., & Kean, M-L. (1996). Acquisition and long-term retention of a gross motor skill in Alzheimer’s disease patients under constant and varied practice conditions. Journal of Neurology, 51B(2), 103–111.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1006/brcg.1993.1013', 'is_inner': False, 'url': 'https://doi.org/10.1006/brcg.1993.1013'}, {'type': 'PubMed', 'value': '8442933', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/8442933/'}]}
    2. Ferraro, F. R., Balota, D. A., & Connor, L. T. (1993). Implicit memory and the formation of new associations in nondemented Parkinson’s disease individuals and individuals with senile dementia of the Alzheimer type: A Serial Reaction Time (SRT) investigation. Brain and Cognition, 21, 163–180.
    1. None
    2. Fitts, P. M., & Posner, M. I. (1967). Human Performance (2nd ed.). Belmont, CA: Brooks/Cole.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '2339182', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/2339182/'}]}
    2. Grafman, J., Weingartner, H., Newhouse, P. A., Thompson, K., Lalonde, F., Litvan, I., et al. (1990). Implicit learning in patients with Alzheimer’s disease. Pharmacopsychiatry, 23, 94–101.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1017/S1461145704004444', 'is_inner': False, 'url': 'https://doi.org/10.1017/s1461145704004444'}, {'type': 'PubMed', 'value': '15228642', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/15228642/'}]}
    2. Grimley Evans, J., Wilcock, G., & Birks, J. (2004). Evidence-based pharmacotherapy of Alzheimer’s disease. International Journal of Neuropsychopharmacology, 7, 351–369.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1037/0735-7044.102.1.141', 'is_inner': False, 'url': 'https://doi.org/10.1037/0735-7044.102.1.141'}, {'type': 'PubMed', 'value': '2965592', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/2965592/'}]}
    2. Heindel, W. C., Butters, N., & Salmon, D. P. (1988). Impaired learning of a motor skill in patients with Huntington’s disease. Behavioral Neuroscience, 102, 141–147.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PMC', 'value': 'PMC6569801', 'is_inner': False, 'url': 'http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6569801/'}, {'type': 'PubMed', 'value': '2521896', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/2521896/'}]}
    2. Heindel, W. C., Salmon, D. P., Shults, W., Walicke, P. A., & Butters, N. (1989). Neuropsychological evidence for multiple implicit memory systems: A comparison of Alzheimer’s, Huntington’s, and Parkinson’s disease patients. Journal of Neuroscience, 9(2), 582–587.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1159/000106633', 'is_inner': False, 'url': 'https://doi.org/10.1159/000106633'}, {'type': 'PubMed', 'value': '9213065', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/9213065/'}]}
    2. Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Ikeda, M., et al. (1997). Procedural memory in patients with Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 8, 210–216.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0028-3932(98)00139-0', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0028-3932(98)00139-0'}, {'type': 'PubMed', 'value': '10408654', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/10408654/'}]}
    2. Jacobs, D. H., Adair, J. C., Williamson, D. J. G., Na, D. L., Gold, M., Foundas, A. L., et al. (1999). Apraxia and motor-skill acquisition in Alzheimer’s disease are dissociable. Neuropsychologia, 37, 875–880.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '1779028', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/1779028/'}]}
    2. Knopman, D. (1991). Long-term retention of implicitly acquired learning in patients with Alzheimer’s disease. Journal of Clinical and Experimental Neuropsychology, 13(6), 880–894.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '3574677', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/3574677/'}]}
    2. Knopman, D. S., & Nissen, M. J. (1987). Implicit learning in patients with probable Alzheimer’s disease. Neurology, 37, 784–788.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '10527111', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/10527111/'}]}
    2. Kuzis, G., Sabe, L., Tiberti, C., Merello, M., Leiguarda, G., & Starkstein, S. E. (1999). Explicit and implicit learning in patients with Alzheimer disease and Parkinson disease with dementia. Neuropsychiatry, Neuropsychology and Behavioral Neurology, 12(4), 265–269.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '9672817', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/9672817/'}]}
    2. Libon, D.J., Bogdanoff, B., Cloud, B. S., Skalina, S., Giovannetti, T., Gitlin, H. L., et al. (1998). Declarative and procedural learning, quantitative measures of the hippocampus, and subcortical white alterations in Alzheimer’s disease and Ischaemic Vascular dementia. Journal of Clinical and Experimental Neuropsychology, 20(1), 30–41.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '14640320', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/14640320/'}]}
    2. Luijpen, M. W., Scherder, E. J. A., Van Someren, E. J. W., Swaab, D. F., & Sergeant, J. A.(2003). Non-pharmacological interventions in cognitively impaired and demented patients: a comparison with cholinesterase inhibitors. Reviews in the neurosciences, 14, 343–368.
    1. None
    2. Magill, R. A. (1993). Motor learning: Concepts and applications (4th ed.). Indianapolis IN: Brown & Benchmark.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1037/0278-7393.22.2.350', 'is_inner': False, 'url': 'https://doi.org/10.1037/0278-7393.22.2.350'}, {'type': 'PubMed', 'value': '8901340', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/8901340/'}]}
    2. Mayr, U. (1996). Spatial attention and implicit sequence learning: Evidemce for independent learning of spatial and nonspatial sequences. Journal of Experimental Psychology: Learning, Memory and Cognition, 22(2), 350–364.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '9347552', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/9347552/'}]}
    2. Poe, M. K., & Seifert, L. S. (1997). Implicit and explicit tests: Evidence for dissociable motor skills in probable Alzheimer’s dementia. Perceptual and Motor Skills, 85, 631–634.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0022-510X(02)00252-6', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0022-510x(02)00252-6'}, {'type': 'PubMed', 'value': '12417349', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/12417349/'}]}
    2. Román, G. C. (2002). Vascular dementia may be the most common form of dementia in the elderly. Journal of Neurology and Science, 203–204, 7–10.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1002/gps.705', 'is_inner': False, 'url': 'https://doi.org/10.1002/gps.705'}, {'type': 'PubMed', 'value': '12461765', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/12461765/'}]}
    2. Rösler, A., Seifritz, E., Kräuchi, K., Spoerl, D., Brokuslaus, I., Proserpi, S-M., et al. (2002). Skill learning in patients with moderate Alzheimer’s disease: a prospective pilot-study of waltz-lessons. International Journal of Geriatric Psychiatry, 17, 1155–1156.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '11992206', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/11992206/'}]}
    2. Rouleau, I., Salmon, D. P., & Vrbancic, M. (2002). Learning, retention and generalization of a mirror tracing skill in Alzheimer’s disease. Journal of Clinical and Experimental Neuropsychology, 24(2), 239–250.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '8847390', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/8847390/'}]}
    2. Sabe, L., Jason, L., Juejati, M., Leigarda, R., & Starkstein, S. E. (1995). Dissociations between declarative and procedural learning in dementia and depression. Journal of Clinical and Experimental Neuropsychology, 17(6), 841–848.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1037/h0076770', 'is_inner': False, 'url': 'https://doi.org/10.1037/h0076770'}]}
    2. Schmidt, R. A. (1975). A schema theory of discrete motor skills. Psychological Review, 82, 225–260.
    1. None
    2. Schmidt, R. A. (1988). Motor control and learning: A behavioral emphasis (2nd ed.). Illinous: Human Kinetics Publishers, Inc.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '14768837', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/14768837/'}]}
    2. Schmidt, R. A. (2003). Motor schema theory after 27 years: Reflections and implications for a new theory. Research Quarterly for Exercise and Sport, 74(4), 366–375.
    1. None
    2. Schmidt, A., & Wrisberg, C. A. (2000). Motor Learning and Performance (2nd ed.). Champaign, IL: Human Kinetics.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '16078659', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/16078659/'}]}
    2. Schölzer-Dorenbosch, C. J. M. (2005). Medicamanteuze behandeling van e ziekte van Alzheimer: De klinische praktijk in Nederland. Tijdschrift voor Gerontologie en Geriatrie, 36, 122–126.
    1. None
    2. Shumway-Cook, A., & Woollacott, M. H. (1995). Motor control: Theory and practical applications. Baltimore: Williams & Wilkins.
    1. None
    2. Smith, G., & Rush, B. K. (2006). Normal aging and mild cognitive impairment. In D. K. Attix & K. A. Welsh-Bohmer (Eds.), Geriatric Neuropsychology: Assessment and Intervention (pp. 27–55). New York/London: Guilford.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '12754679', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/12754679/'}]}
    2. Spaan, P. E. J., Raaijmakers, J. G. W., & Jonker, C. (2003). Alzheimer’s disease versus normal aging: A review of the efficiency of clinical and experimental memory measures. Journal of Clinical and Experimental Neuropsychology, 25(2), 216–233.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '9150509', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/9150509/'}]}
    2. Starkstein, S.E., Sabe, L., Cuerva, A.G., Kuzis, G., & Leigarda, R. (1997). Anosognosia and procedural learning in Alzheimer’s disease. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 10(2), 96–101.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1002/gps.1402', 'is_inner': False, 'url': 'https://doi.org/10.1002/gps.1402'}, {'type': 'PubMed', 'value': '16323253', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/16323253/'}]}
    2. Takeda, A.,Loveman, E., Clegg, A., Kirby, J., Picot, J., Payne, E., et al. (2006). A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer’s disease. International Journal of Geriatric Psychiatry, 21, 17–28.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '9760667', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/9760667/'}]}
    2. Taylor, R. (1998). Spiral maze performance in dementia. Perceptual and Motor Skills, 87, 328–330.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1300/J148v15n03_02', 'is_inner': False, 'url': 'https://doi.org/10.1300/j148v15n03_02'}]}
    2. Tse, D. W., & Spaulding, S. J. (1998). Review of motor control and motor learning: Implications for occupational therapy with individuals with Parkinson’s disease. Physical and Occupational Therapy in Geriatrics, 15(3), 19–38.
    1. Van Cranenburg, B. (2004). Neurorevalidatie; uitgangspunten voor therapie en training na hersenletsel. Maarssen: Elzevier gezondheidszorg.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1037/0894-4105.11.2.261', 'is_inner': False, 'url': 'https://doi.org/10.1037/0894-4105.11.2.261'}, {'type': 'PubMed', 'value': '9110332', 'is_inner': True, 'url': 'http://pubmed.ncbi.nlm.nih.gov/9110332/'}]}
    2. Willingham, B. B., Peterson, E. W., Manning, C., & Brashear, H. R. (1997). Patients with Alzheimer’s disease who cannot perform some motor skills show normal learning of other motor skills. Neuropsychology, 11(2), 261–271.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1111/1467-9280.00201', 'is_inner': False, 'url': 'https://doi.org/10.1111/1467-9280.00201'}]}
    2. Willingham, D. B., & Goedert-Eschmann, K. (1999). The relation between implicit and explicit learning: Evidence for parallel development. Psychological Science, 10(6), 531–534.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1080/09602010042000088', 'is_inner': False, 'url': 'https://doi.org/10.1080/09602010042000088'}]}
    2. Zanetti, O., Zanieri, G., Di Giovanni, G., De Vreese. L. P., Pezzini, A., Metitieri, T., et al. (2001). Effectiveness of procedural memory stimulation in mild Alzheimer’s disease patients: A controlled study. Neuropsychological Rehabilitation, 11, 263–272.

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