A review of the effects of physical activity and exercise on cognitive and brain functions in older adults

Louis Bherer, Kirk I Erickson, Teresa Liu-Ambrose, Louis Bherer, Kirk I Erickson, Teresa Liu-Ambrose

Abstract

Studies supporting the notion that physical activity and exercise can help alleviate the negative impact of age on the body and the mind abound. This literature review provides an overview of important findings in this fast growing research domain. Results from cross-sectional, longitudinal, and intervention studies with healthy older adults, frail patients, and persons suffering from mild cognitive impairment and dementia are reviewed and discussed. Together these finding suggest that physical exercise is a promising nonpharmaceutical intervention to prevent age-related cognitive decline and neurodegenerative diseases.

References

    1. Wang CY, Haskell WL, Farrell SW, et al. Cardiorespiratory fitness levels among us adults 20–49 years of age: findings from the 1999–2004 national health and nutrition examination survey. The American Journal of Epidemiology. 2010;171(4):426–435.
    1. Fratiglioni L, Paillard-Borg S, Winblad B. An active and socially integrated lifestyle in late life might protect against dementia. The Lancet Neurology. 2004;3(6):343–353.
    1. Hertzog C, Kramer AF, Wilson RS, Lindenberger U. Enrichment effects on adult cognitive development: can the functional capacity of older adults be preserved and enhanced? Psychological Science in the Public Interest. 2008;9(1):1–65.
    1. Kramer AF, Bherer L, Colcombe SJ, Dong W, Greenough WT. Environmental influences on cognitive and brain plasticity during aging. Journals of Gerontology A. 2004;59(9):940–957.
    1. Booth FW, Gordon SE, Carlson CJ, Hamilton MT. Waging war on modern chronic diseases: primary prevention through exercise biology. Journal of Applied Physiology. 2000;88(2):774–787.
    1. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. The New England Journal of Medicine. 2002;346(11):793–801.
    1. Larson EB, Wang L, Bowen JD, et al. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Annals of Internal Medicine. 2006;144(2):73–81.
    1. Craik F, Salthouse T. Handbook of Aging and Cognition. 3rd edition. New York, NY, USA: Psychology Press; 2008.
    1. Reuter-Lorenz PA, Park DC. Human neuroscience and the aging mind: a new look at old problems. Journals of Gerontology B. 2010;65(4):405–415.
    1. Penke L, Maniega SM, Murray C, et al. A general factor of brain white matter integrity predicts information processing speed in healthy older people. Journal of Neuroscience. 2010;30(22):7569–7574.
    1. Dennis NA, Cabeza R. Neuroimaging of healthy cognitive aging. In: Craik FIM, Salthouse TA, editors. Handbook of Aging and Cognition. 3rd edition. New York, NY, USA: Psychology Press; 2008. pp. 1–54.
    1. Raz N. The aging brain observed in vivo: differential changes and there modifiers. In: Cabeza R, Nyberg L, Park DC, editors. Cognitive Neuroscience of Aging. New York, NY, USA: Oxford University Press; 2005. pp. 19–57.
    1. Raz N, Ghisletta P, Rodrigue KM, Kennedy KM, Lindenberger U. Trajectories of brain aging in middle-aged and older adults: regional and individual differences. NeuroImage. 2010;51(2):501–511.
    1. Chen JJ, Rosas HD, Salat DH. Age-associated reductions in cerebral blood flow are independent from regional atrophy. NeuroImage. 2011;55(2):468–478.
    1. Abourezk T, Toole T. Effect of task complexity on the relationship between physical fitness and reaction time in older women. Journal of Aging and Physical Activity. 1995;3:251–260.
    1. Clarkson-Smith L, Hartley AA. Relationships between physical exercise and cognitive abilities in older adults. Psychology and Aging. 1989;4(2):183–189.
    1. Hillman CH, Weiss EP, Hagberg JM, Hatfield BD. The relationship of age and cardiovascular fitness to cognitive and motor processes. Psychophysiology. 2002;39(3):303–312.
    1. Renaud M, Bherer L, Maquestiaux F. A high level of physical fitness is associated with more efficient response preparation in older adults. Journals of Gerontology B. 2010;65(3):317–322.
    1. Spirduso WW. Reaction and movement time as a function of age and physical activity level. Journals of Gerontology. 1975;30(4):435–440.
    1. Barnes DE, Yaffe K, Satariano WA, Tager IB. A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults. Journal of the American Geriatrics Society. 2003;51(4):459–465.
    1. Aichberger MC, Busch MA, Reischies FM, Ströhle A, Heinz A, Rapp MA. Effect of physical inactivity on cognitive performance after 2.5 years of follow-up: longitudinal results from the survey of health, ageing, and retirement (SHARE) GeroPsych. 2010;23(1):7–15.
    1. Dustman RE, Ruhling RO, Russell EM, et al. Aerobic exercise training and improved neuropsychological function of older individuals. Neurobiology of Aging. 1984;5(1):35–42.
    1. Rikli RE, Edwards DJ. Effects of a three-year exercise program on motor function and cognitive processing speed in older women. Research Quarterly for Exercise and Sport. 1991;62(1):61–67.
    1. Hawkins HL, Kramer AF, Capaldi D. Aging, exercise, and attention. Psychology and Aging. 1992;7(4):643–653.
    1. Kramer AF, Hahn S, Cohen NJ, et al. Ageing, fitness and neurocognitive function. Nature. 1999;400(6743):418–419.
    1. Albinet CT, Boucard G, Bouquet CA, Audiffren M. Increased heart rate variability and executive performance after aerobic training in the elderly. European Journal of Applied Physiology. 2010;109(4):617–624.
    1. Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychological Science. 2003;14(2):125–130.
    1. Etnier JL, Nowell PM, Landers DM, Sibley BA. A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Research Reviews. 2006;52(1):119–130.
    1. Smiley-Oyen AL, Lowry KA, Francois SJ, Kohut ML, Ekkekakis P. Exercise, fitness, and neurocognitive function in older adults: the “selective improvement” and “cardiovascular fitness” hypotheses. Annals of Behavioral Medicine. 2008;36(3):280–291.
    1. Renaud M, Maquestiaux F, Joncas S, Kergoat MJ, Bherer L. The effect of three months of aerobic training on response preparation in older adults. Frontiers in Aging Neuroscience. 2010;2(article 148)
    1. Smith PJ, Blumenthal JA, Hoffman BM, et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosomatic Medicine. 2010;72(3):239–252.
    1. Angevaren M, Aufdemkampe G, Verhaar HJ, Aleman A, Vanhees L. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database of Systematic Reviews. 2008;(2)CD005381
    1. Cassilhas RC, Viana VAR, Grassmann V, et al. The impact of resistance exercise on the cognitive function of the elderly. Medicine and Science in Sports and Exercise. 2007;39(8):1401–1407.
    1. Liu-Ambrose T, Donaldson MG, Ahamed Y, et al. Otago home-based strength and balance retraining improves executive functioning in older fallers: a randomized controlled trial. Journal of the American Geriatrics Society. 2008;56(10):1821–1830.
    1. Fabel K, Kempermann G. Physical activity and the regulation of neurogenesis in the adult and aging brain. NeuroMolecular Medicine. 2008;10(2):59–66.
    1. Liu-Ambrose T, Nagamatsu LS, Graf P, Beattie BL, Ashe MC, Handy TC. Resistance training and executive functions: a 12-month randomized controlled trial. Archives of Internal Medicine. 2010;170(2):170–178.
    1. Rosano C, Newman AB, Katz R, Hirsch CH, Kuller LH. Association between lower digit symbol substitution test score and slower gait and greater risk of mortality and of developing incident disability in well-functioning older adults. Journal of the American Geriatrics Society. 2008;56(9):1618–1625.
    1. Dumurgier J, Elbaz A, Ducimetière P, Tavernier B, Alpérovitch A, Tzourio C. Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study. The British Medical Journal. 2009;339b4460
    1. Hardy SE, Perera S, Roumani YF, Chandler JM, Studenski SA. Improvement in usual gait speed predicts better survival in older adults. Journal of the American Geriatrics Society. 2007;55(11):1727–1734.
    1. Voelcker-Rehage C, Nieman C. Structural and functional brain changes related to different types of physical activity across the life span. Neuroscience and Biobehavioral Reviews. 2013
    1. Spirduso W, Francis K, MacRae P. Physical Dimensions of Aging. 2nd edition. Champaign, Ill, USA: Human Kinetics; 2005.
    1. Lista I, Sorrentino G. Biological mechanisms of physical activity in preventing cognitive decline. Cellular and Molecular Neurobiology. 2010;30(4):493–503.
    1. Black JE, Isaacs KR, Anderson BJ, Alcantara AA, Greenough WT. Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proceedings of the National Academy of Sciences of the United States of America. 1990;87(14):5568–5572.
    1. Isaacs KR, Anderson BJ, Alcantara AA, Black JE, Greenough WT. Exercise and the brain: angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning. Journal of Cerebral Blood Flow and Metabolism. 1992;12(1):110–119.
    1. van Praag H, Shubert T, Zhao C, Gage FH. Exercise enhances learning and hippocampal neurogenesis in aged mice. Journal of Neuroscience. 2005;25(38):8680–8685.
    1. Lledo P, Alonso M, Grubb MS. Adult neurogenesis and functional plasticity in neuronal circuits. Nature Reviews Neuroscience. 2006;7(3):179–193.
    1. Eadie BD, Redila VA, Christie BR. Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density. Journal of Comparative Neurology. 2005;486(1):39–47.
    1. Hu S, Ying Z, Gomez-Pinilla F, Frautschy SA. Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus. Brain Research. 2009;1249:191–201.
    1. Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(7):3017–3022.
    1. Erickson KI, Kramer AF. Aerobic exercise effects on cognitive and neural plasticity in older adults. The British Journal of Sports Medicine. 2009;43(1):22–24.
    1. Hillman CH, Erickson KI, Kramer AF. Be smart, exercise your heart: exercise effects on brain and cognition. Nature Reviews Neuroscience. 2008;9(1):58–65.
    1. Kramer AF, Erickson KI, Colcombe SJ. Exercise, cognition, and the aging brain. Journal of Applied Physiology. 2006;101(4):1237–1242.
    1. Liu-Ambrose T, Nagamatsu LS, Voss MW, Khan KM, Handy TC. Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial. Neurobiology of Aging. 2012;33(8):1690–1698.
    1. Voelcker-Rehage C, Godde B, Staudinger UM. Physical and motor fitness are both related to cognition in old age. European Journal of Neuroscience. 2010;31(1):167–176.
    1. Colcombe SJ, Erickson KI, Raz N, et al. Aerobic fitness reduces brain tissue loss in aging humans. Journals of Gerontology A. 2003;58(2):176–180.
    1. Erickson KI, Prakash RS, Voss MW, et al. Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus. 2009;19(10):1030–1039.
    1. Ruscheweyh R, Willemer C, Krüger K, et al. Physical activity and memory functions: an interventional study. Neurobiology of Aging. 2011;32(7):1304–1319.
    1. Colcombe SJ, Kramer AF, Erickson KI, et al. Cardiovascular fitness, cortical plasticity, and aging. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(9):3316–3321.
    1. Voss MW, Prakash RS, Erickson KI, et al. Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Frontiers in Aging Neuroscience. 2010;2(article 32)
    1. Spirduso W, Poon L, Chodzo-Zajko W. Using resources and reserves in an exercise-cognition model. In: Spirduso W, Poon L, Chodzo-Zajko W, editors. Exercise and Its Mediating Effects on Cognition. Champaign, Ill, USA: Human Kinetics; 2008. pp. 3–11.
    1. Bartholomew J, Ciccolo J. Exercise, depression, and cognition. In: Spirduso W, Poon L, Chodzo-Zajko W, editors. Exercise and Its Mediating Effects on Cognition. Champaign, Ill, USA: Human Kinetics; 2008. pp. 33–46.
    1. McAuley E, Elavsky S. Self-efficacy, physical activity, and cognitive function. In: Spirduso W, Poon L, Chodzo-Zajko W, editors. Exercise and Its Mediating Effects on Cognition. Champaign, Ill, USA: Human Kinetics; 2008. pp. 69–84.
    1. Joseph J. Diet, motor behavior, and cognition. In: Spirduso W, Poon L, Chodzo-Zajko W, editors. Exercise and Its Mediating Effects on Cognition. Champaign, Ill, USA: Human Kinetics; 2008. pp. 119–129.
    1. Lopez M. Exercise and sleep quality. In: Spirduso W, Poon L, Chodzo-Zajko W, editors. Exercise and Its Mediating Effects on Cognition. Champaign, Ill, USA: Human Kinetics; 2008. pp. 131–146.
    1. Vitiello MV. Exercise, sleep, and cognition: interactions in aging. In: Spirduso W, Poon L, Chodzo-Zajko W, editors. Exercise and Its Mediating Effects on Cognition. Champaign, Ill, USA: Human Kinetics; 2008. pp. 146–165.
    1. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. Journals of Gerontology A. 2001;56(3):M146–M156.
    1. Rockwood K, Howlett SE, MacKnight C, et al. Prevalence, attributes, and outcomes of fi tness and frailty in community-dwelling older adults: report from the Canadian study of health and aging. Journals of Gerontology A. 2004;59(12):1310–1317.
    1. Landi F, Abbatecola AM, Provinciali M, et al. Moving against frailty: does physical activity matter? Biogerontology. 2010;11(5):537–545.
    1. Peterson MJ, Giuliani C, Morey MC, et al. Physical activity as a preventative factor for frailty: the health, aging, and body composition study. Journals of Gerontology A. 2009;64(1):61–68.
    1. Helbostad JL, Sletvold O, Moe-Nilssen R. Home training with and without additional group training in physically frail old people living at home: effect on health-related quality of life and ambulation. Clinical Rehabilitation. 2004;18(5):498–508.
    1. Langlois F, Vu TTM, Chassé K, Dupuis G, Kergoat MJ, Bherer L. Benefits of physical exercise training on cognition and quality of life in frail older adults. Journals of Gerontology B. 2013;68(3):400–404.
    1. Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimer’s & Dementia. 2011;7(2)
    1. Geda YE, Roberts RO, Knopman DS, et al. Physical exercise, aging, and mild cognitive impairment a population-based study. Archives of Neurology. 2010;67(1):80–86.
    1. Burns JM, Cronk BB, Anderson HS, et al. Cardiorespiratory fitness and brain atrophy in early Alzheimer disease. Neurology. 2008;71(3):210–216.
    1. Chang M, Jonsson PV, Snaedal J, et al. The effect of midlife physical activity on cognitive function among older adults: AGES—Reykjavik study. Journals of Gerontology A. 2010;65(12):1369–1374.
    1. Boyle PA, Buchman AS, Wilson RS, Leurgans SE, Bennett DA. Physical frailty is associated with incident mild cognitive impairment in community-based older persons. Journal of the American Geriatrics Society. 2010;58(2):248–255.
    1. Sofi F, Valecchi D, Bacci D, et al. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. Journal of Internal Medicine. 2011;269(1):107–117.
    1. Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Archives of Physical Medicine and Rehabilitation. 2004;85(10):1694–1704.
    1. Lautenschlager NT, Cox KL, Flicker L, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. The Journal of the American Medical Association. 2008;300(9):1027–1037.
    1. Eggermont LHP, Swaab DF, Hol EM, Scherder EJA. Walking the line: a randomised trial on the effects of a short term walking programme on cognition in dementia. Journal of Neurology, Neurosurgery and Psychiatry. 2009;80(7):802–804.
    1. Baker LD, Frank LL, Foster-Schubert K, et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Archives of Neurology. 2010;67(1):71–79.
    1. Kemoun G, Thibaud M, Roumagne N, et al. Effects of a physical training programme on cognitive function and walking efficiency in elderly persons with dementia. Dementia and Geriatric Cognitive Disorders. 2010;29(2):109–114.
    1. Lam LCW, Chau RCM, Wong BML, et al. Interim follow-up of a randomized controlled trial comparing Chinese style mind body (Tai Chi) and stretching exercises on cognitive function in subjects at risk of progressive cognitive decline. International Journal of Geriatric Psychiatry. 2011;26(7):733–740.
    1. Nagamatsu LS, Chan A, Davis JC, et al. Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. Journal of Aging Research. 2013;2013:10 pages.861893
    1. Cyarto EV, Lautenschlager NT, Desmond PM, et al. Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL active trial. BMC Psychiatry. 2012;12(article 167)
    1. Tyndall AV, Davenport MH, Wilson BJ, et al. The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults. BMC Geriatrics. 2013;13(article 21)

Source: PubMed

3
Abonnieren