CRRTnet: a prospective, multi-national, observational study of continuous renal replacement therapy practices

Michael Heung, Sean M Bagshaw, Andrew A House, Luis A Juncos, Robin Piazza, Stuart L Goldstein, Michael Heung, Sean M Bagshaw, Andrew A House, Luis A Juncos, Robin Piazza, Stuart L Goldstein

Abstract

Background: Continuous renal replacement therapy (CRRT) is the recommended modality of dialysis for critically ill patients with hemodynamic instability. Yet there remains significant variability in how CRRT is prescribed and delivered, and limited evidence-basis to guide practice.

Methods: This is a prospective, multi-center observational study of patients undergoing CRRT. Initial enrollment phase will occur at 4 academic medical centers in North America over 5 years, with a target enrollment of 2000 patients. All adult patients (18-89 years of age) receiving CRRT will be eligible for inclusion; patients who undergo CRRT for less than 24 h will be excluded from analysis. Data collection will include patient characteristics at baseline and at time of CRRT initiation; details of CRRT prescription and delivery, including machine-generated treatment data; and patient outcomes.

Discussion: The goal of this study is to establish a large comprehensive registry of critically ill adults receiving CRRT. Specific aims include describing variations in CRRT prescription and delivery across quality domains; validating quality measures for CRRT care by correlating processes and outcomes; and establishing a large registry for use in quality improvement and benchmarking efforts. For initial analyses, some particular areas of interest are anticoagulation protocols; approach to fluid overload; CRRT-related workload; and patient safety.

Trial registration: Registered on ClinicalTrials.gov 1/10/2014: NCT02034448.

Keywords: Acute kidney injury; Continuous renal replacement therapy; Critical care; Quality.

Conflict of interest statement

Ethics approval and consent to participate

The study was reviewed and approved by the local institutional review board (IRB) for each participating site. In all cases, a waiver for informed consent was granted due to the observational nature of the study. The names of each IRB and specific reference number for CRRTnet are as follows:

- University of Michigan IRB-Med (HUM00074701)

- University of Alberta Health Research Ethics Board (File # Pro00038405)

- Western University Research Ethics Board (File # 103957)

- University of Mississippi Medical Center IRB (#2013–0190)

- Cincinnati Children’s Hospital Medical Center (#2014–5675)

Consent for publication

Not applicable.

Competing interests

SMB and AAH have consulted for and received speaking fees from Baxter Healthcare Corp.

All other authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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