The efficacy and tolerability of sports drink versus water in bowel preparations: a randomised controlled study

Zhixin Zhang, Hui Gao, Xin Yuan, Cenqin Liu, Zhenfei Bao, Siyi Yu, Haofen Xie, Weihong Wang, Jiarong Xie, Lei Xu, Zhixin Zhang, Hui Gao, Xin Yuan, Cenqin Liu, Zhenfei Bao, Siyi Yu, Haofen Xie, Weihong Wang, Jiarong Xie, Lei Xu

Abstract

Background: An optimal bowel preparation can result in an improved colonoscopy. This study was to compare the effectiveness and safety of the use of a sports drink (Mizone) plus polyethylene glycol (PEG) solution with a water plus PEG solution in bowel preparations.

Methods: This was a randomised controlled study. All of the included patients were randomly divided into the following two groups: the PEG + Mizone group and the PEG + water group. The palatability of the solution was measured through the use of questionnaires. Additionally, bowel cleanliness was evaluated according to the Ottawa Bowel Preparation Scale (OBPS, 0-14, with higher values indicating worse cleanliness), as well as with the aid of colonoscopy videos.

Results: A total of 270 patients were enrolled. The rate of adequate bowel preparation was 74.8% in the PEG + Mizone group and 68.9% in the PEG + water group, with a risk difference of 5.9% (95% CI: - 4.8-16.6%), which indicated noninferiority (noninferiority margin: - 9.5% < - 4.8%). However, patients rated the palatability (65.9% vs 44.4%, P < 0.001) and willingness to recommend or repeat (88.9% vs 75.6%, P = 0.004) the administration of the PEG + Mizone preparation as being better than those of the PEG + water preparation. The rates of adverse events during the bowel preparations were not significantly different between the two groups, except for bloating (PEG + Mizone vs PEG + water, 4.4% vs 13.3%, P = 0.010).

Conclusion: The concomitant use of PEG + Mizone was a well tolerated and effective bowel preparation, compared with the PEG + water treatment.

Trial registration: ClinicalTrials.gov NCT04247386 . Registered on 30 Jan 2020.

Keywords: Bowel preparation; Colonoscopy; Mizone; Polyethylene glycol; Tolerability.

Conflict of interest statement

The authors declare that they have no competing interests.

© 2022. The Author(s).

Figures

Fig. 1
Fig. 1
Study flowchart
Fig. 2
Fig. 2
Non-inferiority of the PEG + Mizone regimen relative to the PEG + water regimen. ITT, intention-to-treat; PP, per-protocol; RD, risk difference. Adequate preparation: Ottawa Bowel Preparation Scale 

Fig. 3

The incidence of secondary endpoints.…

Fig. 3

The incidence of secondary endpoints. Error bars represent 95% confidence intervals

Fig. 3
The incidence of secondary endpoints. Error bars represent 95% confidence intervals

Fig. 4

The incidence of advent events.…

Fig. 4

The incidence of advent events. Error bars represent 95% confidence intervals

Fig. 4
The incidence of advent events. Error bars represent 95% confidence intervals
Fig. 3
Fig. 3
The incidence of secondary endpoints. Error bars represent 95% confidence intervals
Fig. 4
Fig. 4
The incidence of advent events. Error bars represent 95% confidence intervals

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Source: PubMed

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