Early and 1-year outcomes of aortic root surgery in patients with Marfan syndrome: a prospective, multicenter, comparative study
Joseph S Coselli, Irina V Volguina, Scott A LeMaire, Thoralf M Sundt, Heidi M Connolly, Elizabeth H Stephens, Hartzell V Schaff, Dianna M Milewicz, Luca A Vricella, Harry C Dietz, Charles G Minard, D Craig Miller, Aortic Valve Operative Outcomes in Marfan Patients Study Group, J S Coselli, H C Dietz, H M Connolly, D M Milewicz, R R Favaloro, K-L Chan, A Haverich, H H Sievers, F W Mohr, M I M Versteegh, J S Coselli, R P Cochran, C Frumiento, V L Gott, L A Vricella, J P Schwartz, T M Sundt 3rd, H V Schaff, N T Kouchoukos, A DeAnda, L N Girardi, T G Gleason, C Malaisrie, D C Miller, T G Gleason, M R Moon, Joseph S Coselli, Irina V Volguina, Scott A LeMaire, Thoralf M Sundt, Heidi M Connolly, Elizabeth H Stephens, Hartzell V Schaff, Dianna M Milewicz, Luca A Vricella, Harry C Dietz, Charles G Minard, D Craig Miller, Aortic Valve Operative Outcomes in Marfan Patients Study Group, J S Coselli, H C Dietz, H M Connolly, D M Milewicz, R R Favaloro, K-L Chan, A Haverich, H H Sievers, F W Mohr, M I M Versteegh, J S Coselli, R P Cochran, C Frumiento, V L Gott, L A Vricella, J P Schwartz, T M Sundt 3rd, H V Schaff, N T Kouchoukos, A DeAnda, L N Girardi, T G Gleason, C Malaisrie, D C Miller, T G Gleason, M R Moon
Abstract
Objective: To compare the 1-year results after aortic valve-sparing (AVS) or valve-replacing (AVR) aortic root replacement from a prospective, international registry of 316 patients with Marfan syndrome (MFS).
Methods: Patients underwent AVS (n = 239, 76%) or AVR (n = 77, 24%) aortic root replacement at 19 participating centers from 2005 to 2010. One-year follow-up data were complete for 312 patients (99%), with imaging findings available for 293 (94%). The time-to-events were compared between groups using Kaplan-Meier curves and Cox proportional hazards models.
Results: Two patients (0.6%)--1 in each group--died within 30 days. No significant differences were found in early major adverse valve-related events (MAVRE; P = .6). Two AVS patients required early reoperation for coronary artery complications. The 1-year survival rates were similar in the AVR (97%) and AVS (98%) groups; the procedure type was not significantly associated with any valve-related events. At 1 year and beyond, aortic regurgitation of at least moderate severity (≥2+) was present in 16 patients in the AVS group (7%) but in no patients in the AVR group (P = .02). One AVS patient required late AVR.
Conclusions: AVS aortic root replacement was not associated with greater 30-day mortality or morbidity rates than AVR root replacement. At 1 year, no differences were found in survival, valve-related morbidity, or MAVRE between the AVS and AVR groups. Of concern, 7% of AVS patients developed grade ≥2+ aortic regurgitation, emphasizing the importance of 5 to 10 years of follow-up to learn the long-term durability of AVS versus AVR root replacement in patients with MFS.
Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
Source: PubMed