The answer is 17 years, what is the question: understanding time lags in translational research

Zoë Slote Morris, Steven Wooding, Jonathan Grant, Zoë Slote Morris, Steven Wooding, Jonathan Grant

Abstract

This study aimed to review the literature describing and quantifying time lags in the health research translation process. Papers were included in the review if they quantified time lags in the development of health interventions. The study identified 23 papers. Few were comparable as different studies use different measures, of different things, at different time points. We concluded that the current state of knowledge of time lags is of limited use to those responsible for R&D and knowledge transfer who face difficulties in knowing what they should or can do to reduce time lags. This effectively 'blindfolds' investment decisions and risks wasting effort. The study concludes that understanding lags first requires agreeing models, definitions and measures, which can be applied in practice. A second task would be to develop a process by which to gather these data.

Figures

Figure 1
Figure 1
A conceptual model of the journey of health (biomedical) research from research into benefit, as derived from the literature
Figure 2
Figure 2
Chart showing the approximate range and average time lag reported in studies of time lags in health research. NB – HERG is the Health Economics Research Group at Brunel University

References

    1. Westfall J, Mold J, Fagnan L Practice-based research – “Blue Highways” on the NIH roadmap. JAMA 2007;297:403–6
    1. Cooksey D A review of UK health research funding: Norwich: HMSO, 2006
    1. Trochim W Translation Won't Happen Without Dissemination and Implementation: Some Measurement and Evaluation Issues. 3rd Annual Conference on the Science of Dissemination and Implementation Bethesda, MD: 2010
    1. Greenhalgh T, Robert G, Macfarlane F, Bate P, Kyriakidou O Diffusion of Innovations in Service Organizations: Systematic Review and Recommendations. Milbank Q 2004;82:581–629
    1. Rogers E Diffusion of innovations. 4th edn New York, NY: The Free Press, 1995
    1. Packer C, Simpson S, Stevens A International diffusion of new health technologies: A ten-country analysis of six health technologies. Int J Technol Assess Health Care 2006;22:419–28
    1. Davis D, Evans M, Jadad A, et al. The case for knowledge translation: shortening the journey from evidence to effect. BMJ 2003;327:33–5
    1. Lang ES, Wyer PC, Haynes RB Knowledge translation: Closing the evidence-to-practice gap. Ann Emerg Med 2007;49:355–63
    1. Graham ID, Logan J, Harrison MB, et al. Lost in knowledge translation: Time for a map? J Contin Educ Health Prof 2006;26:13–24
    1. Graham I, Tetroe J, Group KTR Some theoretical underpinnings of knowledge translation. Acad Emerg Med 2007;14:936–41
    1. Baumbusch J, Kirkham S, Khan K, et al. Pursuing common agendas: a collaborative model for knowledge translation between research and practice in clinical settings. Res Nurs Health 2008;31:130–40
    1. Ward V, House A, Hamer S Developing a framework for transferring knowledge into action: a thematic analysis of the literature. J Health Serv Res Policy 2009;14:156–64
    1. Health Economics Research Group, Office of Health Economics, RAND Europe Medical Research: What's it Worth? Estimating the Economic Benefits from Medical Research in the UK. London: UK Evaluation Forum, 2008
    1. Yokote G, Utterback R Time lapses in information dissemination: research laboratory to physician's office. Bull Med Libr Assoc 1974;62:251.
    1. Green L, Ottoson J, García C, Hiatt R Diffusion theory and knowledge dissemination, utilization, and integration in public health. Annu Rev Public Health 2009;30:151–74
    1. Balas E, Boren S Managing Clinical Knowledge for Health Care Improvement. : van Bemmel JH, McCray AT, Yearbook of Medical Informatics. Stuttgart: Schattauer Verlagsgesellschaft mbH, 2000:65–70
    1. Grant J, Green L, Mason B Basic research and health: a reassessment of the scientific basis for the support of biomedical science. Res Eval 2003;12:217–24
    1. Wratschko K Empirical Setting: The pharmaceutical industry. Strategic Orientation and Alliance Portfolio Configuration. New York, NY: Springer, 2009
    1. Grant J, Green L, Mason B From bedside to bench: Comroe and Dripps revisited. HERG Research Report No 30. Uxbridge: The Health Economics Research Group, Brunel University, 2003
    1. Khoury M, Gwinn M, Yoon P, Dowling N, Moore C, Bradley L The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med 2007;9:665.
    1. Khoury MJ, Gwinn M, Ioannidis JP The emergence of translational epidemiology: from scientific discovery to population health impact. Am J Epidemiol 2010;172:517–24
    1. Dougherty D, Conway P The “3T's” road map to transform US health care: the “how” of high-quality care. JAMA 2008;299:2319–21
    1. Woolf S The meaning of translational research and why it matters. JAMA 2008;299:211–13
    1. Balconi M, Brusoni S, Orsenigo L In defence of the linear model: An essay. Res Policy 2010;39:1–13
    1. Mason C, Manzotti E The Translation Cycle: round and round in cycles is the only way forward for regenerative medicine. Regen Med 2010;5:153–5
    1. Reis S, McDonald M, Byers S Crossing the Research Valleys of Death: The University of Pittsburgh Approach. Clin Trans Sci 2008;1:9–10
    1. Wang-Gillam A, Williams K, Novello S, Gao F, Scagliotti G, Govindan R Time to activate lung cancer clinical trials and patient enrollment: A representative comparison study between two academic centers across the Atlantic. J Clin Oncol 2010;28:3803–7
    1. Decullier E, Lheritier V, Chapuis F Fate of biomedical research protocols and publication bias in France: retrospective cohort study. BMJ 2005;331:19.
    1. Stern J, Simes R Publication bias: evidence of delayed publication in a cohort study of clinical research projects. BMJ 1997;315:640–5
    1. Grant J, Cottrell R, Cluzeau F, Fawcett G Evaluating “payback” on biomedical research from papers cited in clinical guidelines: applied bibliometric study. BMJ 2000;320:1107–11
    1. DiMasi J, Hansen R, Grabowski H The price of innovation: new estimates of drug development costs. J Health Econ 2003;22:151–85
    1. Sternitzke C Knowledge sources, patent protection, and commercialization of pharmaceutical innovations. Res Policy 2010;39:810–21
    1. Ioannidis J Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials. JAMA 1998;279:281.
    1. van Luijn J, Stolk P, Gribnau F, Leufkens H. Gap in publication of comparative information on new medicines. Br J Clin Pharmacol 2008;65:716–22
    1. Mansfield E Academic research and industrial innovation. Res Policy 1991;20:1–12
    1. Cockburn I, Henderson R Public–private interaction in pharmaceutical research. PNAS 1996;93:12725.
    1. Dwan K, Altman D, Arnaiz J, et al. Systematic review of the empirical evidence of study publication bias and outcome reporting bias. PLoS One 2008;3:3081
    1. Contopoulos-Ioannidis D, Alexiou G, Gouvias T, Ioannidis J Life cycle of translational research for medical interventions. Science 2008;321:1298–9
    1. Hopewell S, Clarke M, Stewart L, Tierney J Time to publication for results of clinical trials. Cochrane Database Syst Rev 2007;(2):MR000011
    1. Antman E, Lau J, Kupelnick B, Mosteller F, Chalmers T A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts: treatments for myocardial infarction. JAMA 1992;268:240–8
    1. Misakian A, Bero L Publication bias and research on passive smoking: comparison of published and unpublished studies. JAMA 1998;280:250–3
    1. Harris P, Takeda A, Loveman E, Hartwell D Time to full publication of studies of anticancer drugs for breast cancer, and the potential for publication bias. Int J Technol Assess Health Care 2010;26:110–16
    1. Takeda A, Loveman E, Harris P, Hartwell D, Welch K Time to full publication of studies of anti-cancer medicines for breast cancer and the potential for publication bias: a short systematic review. Health Technol Assess 2008;12:1–68
    1. Easterbrook P, Gopalan R, Berlin J, Matthews D Publication bias in clinical research. Lancet 1991;337:867–72
    1. Dickersin K, Chan S, Chalmersx T, Sacks H, Smith H. Jr Publication bias and clinical trials. Control Clin Trials 1987;8:343–53
    1. Dickersin K The existence of publication bias and risk factors for its occurrence. JAMA 1990;263:1385–9
    1. Grol R, Grimshaw J From best evidence to best practice: effective implementation of change in patients' care. Lancet 2003;362:1225–30
    1. Altman D, Goodman S Transfer of technology from statistical journals to the biomedical literature: past trends and future predictions. JAMA 1994;272:129–32
    1. Pulido M, González J, Sanz F Original articles published in Medicina Clínica during 30 years (1962–1992): number of authors, interval between acceptance and publication and bibliographic references. Med Clin 1994;103:770–5
    1. Tsuji K, Tsutani K Follow the leader. Nature 2008;453:851–2
    1. Grant J, Lewison G, May R Government funding of research and development. Science 1997;278:878–80
    1. Newby D, Webb D Translational research: a priority for health and wealth. Heart 2010;96:815–16
    1. Holgate S The future of lung research in the UK. Thorax 2007;62:1028–32
    1. Trochim W, Kane C, Graham M, Pincus H Evaluating translation research. A process marker model. Clinical and Translation Science 2011;4:153–62
    1. Comroe J, Dripps R Scientific basis for the support of biomedical science. Science 1976;192:105–11
    1. DiMasi J, Hansen R, Grabowski H, Lasagna L Cost of innovation in the pharmaceutical industry. J Health Econ 1991;10:107–42

Source: PubMed

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