Assessment of Bone Micro-Architecture Using HR-pQCT

Inclusion Criteria:

1. Men 50-85 years old
2. Patients must be willing to undergo a DXA scan.
3. Patients should be willing to undergo HRpQCT scan of the radius and tibia.

Exclusion Criteria:

1. Inability to tolerate CT scans

2. Use of medications known to impact bone and mineral metabolism:

   • use of a bisphosphonate or teriparatide in the last year or for >12 months ever;
   • current calcitonin;
   • prednisone >5 mg daily or the equivalent glucocorticoid for >10 days in the last 3 months;
   • current testosterone therapy;
   • current thiazolidinedione (TZD);
   • current androgen deprivation therapy;
   • current use of an antiepileptic agent that alters hepatic vitamin D clearance;
   • use of thyroid hormone replacement with current thyroid stimulating hormone <0.1 mIU/L
3. Disease known to affect bone (e.g., primary hyperparathyroidism, Pagets disease, clinically significant liver disease)
4. Illicit drug use or alcohol use >3 drinks/day
5. Serum calcium >10.2 mg/dL or calculated creatinine clearance <30 mL/min
6. Weight >350 pounds (the maximum weight limit of the DXA)
7. Hardware in the lumbar spine
8. History of bilateral hip replacement, or bilateral wrist or ankle fracture