EXercise TRAining and Sedentary Lifestyle on Clinical Outcomes in Patients With COVID-19 (WHO)
The Impact of EXercise TRAining, Physical Activity and Sedentary Lifestyle on Clinical Outcomes in Surviving Patients Infected With the Severe Acute Respiratory Syndrome Coronavirus 2: Cross-sectional Study
Descripción general del estudio
Estado
Intervención / Tratamiento
Descripción detallada
The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the 2019 novel coronavirus (COVID-19) disease, initially discovered in the city of Wuhan, China, at the end of December 2019. In March 2020, the World Health Organization (WHO) declared SARS-CoV-2 as a worldwide pandemic. The disease quickly spread to several continents, also reaching Brazil strongly. This pandemic claimed (and still does) several victims, affecting more than 3 million confirmed cases worldwide with more than 200,000 deaths (official data: coronavirus.jhu.edu/map.html). In Brazil alone, by the time of writing this research project, 60,311 cases have been confirmed with 4,117 deaths. Epidemiological studies show that these numbers can be even higher, reaching up to eight times the number of cases.
As a new virus with such lethality and without the knowledge of its pathophysiology, WHO and the governments of each country have adopted isolation and social distance as a preventive measure to contain the spread of the virus, especially among the most vulnerable people such as the elderly, obese, diabetics and patients with cardiovascular diseases. So far, there is no effective and scientifically proven treatment for the disease, nor a vaccine for its effective control. In this sense, preventive measures such as personal hygiene, good nutrition and physical exercise seem to be the best forms of prevention. However, it is not known whether these measures can prevent contagion or whether they help the recovery of patients infected with SARS-CoV-2. It is well known that exercise training improves the response of the immune system providing protection against infections caused by intracellular microorganisms, thus being an important prevention strategy against SARS-CoV-2.
The present study aims to assess the impact of exercise training, physical activity, and sedentary lifestyle on clinical outcomes in surviving patients infected with the SARS-CoV-2 virus. Therefore, this study will evaluate cross-sectionally and through a questionnaire in Portuguese and English on the internet, whether physically active patients have better outcomes for the disease such as shorter hospital stay, lesser symptoms, lesser need for mechanical ventilation and medications.
Tipo de estudio
Inscripción (Actual)
Contactos y Ubicaciones
Ubicaciones de estudio
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Sao Paulo
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São Paulo, Sao Paulo, Brasil, 05403-900
- Marcelo Rodrigues dos Santos
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
- Niño
- Adulto
- Adulto Mayor
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Método de muestreo
Población de estudio
Descripción
Inclusion Criteria:
- Men and women recovered and survivors of the disease
- With or without symptoms
- Patients with disease confirmation by reverse transcription-polymerase chain reaction (RT-PCR) test, blood test (serology), and a rapid antibody test
- With or without the need for hospitalization (nursery, semi-intensive and intensive unit)
- With or without the need for drug treatment
- Presence of any chronic disease such as diabetes, hypertension, coronary artery disease, obesity, metabolic syndrome, cancer, among others
- Literate patients in Portuguese and/or English.
Exclusion Criteria:
- Illiterate patients with difficulties in filling out the electronic form
- Patients still hospitalized and/or with symptoms of COVID-19
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
Cohortes e Intervenciones
Grupo / Cohorte |
Intervención / Tratamiento |
|---|---|
|
Physically active
Those who receive regular amounts of physical activity.
Those who participate in a minimum of 150 minutes of moderate exercise, or 75 minutes of a more vigorous regimen as recommended by the health organizations.
Additionally, a person who spend less time sitting (i.e.
watching television, surfing the web, playing video games).
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Clinical, anthropometric, and sociodemographic variables to characterize the sample will be collected using the Google Form.
The same tool will be used to collect clinical variables (outcomes), as well as to obtain data on the level of physical activity and sedentary behavior time (predictor variables) prior to SARS-CoV-2 contamination.
For this, we will use the International Physical Activity Questionnaire (IPAQ).
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Sedentary
Those who do not receive regular amounts of physical activity.
Where physical inactivity is considered the failure to meet the recommendations of the health organizations, stating that an individual should participate in a minimum of 150 minutes of moderate exercise, or 75 minutes of a more vigorous regimen.
Sitting about 70-85% of the time (i.e.
watching television, surfing the web, playing video games) is also considered a person living a sedentary lifestyle.
|
Clinical, anthropometric, and sociodemographic variables to characterize the sample will be collected using the Google Form.
The same tool will be used to collect clinical variables (outcomes), as well as to obtain data on the level of physical activity and sedentary behavior time (predictor variables) prior to SARS-CoV-2 contamination.
For this, we will use the International Physical Activity Questionnaire (IPAQ).
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Number of hospitalizations
Periodo de tiempo: Up to 6 months after hospital discharge and/or full recovery from the disease (asymptomatic)
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Number of hospitalizations required due to COVID-19
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Up to 6 months after hospital discharge and/or full recovery from the disease (asymptomatic)
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Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Percentage of symptoms of the disease
Periodo de tiempo: Up to 6 months after hospital discharge and/or full recovery from the disease (asymptomatic)
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Symptoms such as fever, cough, shortness of breathe, and muscle pain due to COVID-19
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Up to 6 months after hospital discharge and/or full recovery from the disease (asymptomatic)
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Length of hospital stay
Periodo de tiempo: Up to 6 months after hospital discharge and/or full recovery from the disease (asymptomatic)
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Length of hospital stay required due to COVID-19
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Up to 6 months after hospital discharge and/or full recovery from the disease (asymptomatic)
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Percentage of mechanical ventilation
Periodo de tiempo: Up to 6 months after hospital discharge and/or full recovery from the disease (asymptomatic)
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Need for mechanical ventilation during hospitalization due to COVID-19
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Up to 6 months after hospital discharge and/or full recovery from the disease (asymptomatic)
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Colaboradores e Investigadores
Patrocinador
Investigadores
- Investigador principal: Marcelo R Santos, PhD, University of Sao Paulo Medical School
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Actual)
Finalización del estudio (Actual)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- COVID-19
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
Descripción del plan IPD
Marco de tiempo para compartir IPD
Criterios de acceso compartido de IPD
Tipo de información de apoyo para compartir IPD
- PROTOCOLO DE ESTUDIO
- SAVIA
- RSC
Información sobre medicamentos y dispositivos, documentos del estudio
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