Effects of the Dietary Approaches to Stop Hypertension (DASH) eating plan on cardiovascular risks among type 2 diabetic patients: a randomized crossover clinical trial

Leila Azadbakht, Nafiseh Rashidi Pour Fard, Majid Karimi, Mohammad Hassan Baghaei, Pamela J Surkan, Majid Rahimi, Ahmad Esmaillzadeh, Walter C Willett, Leila Azadbakht, Nafiseh Rashidi Pour Fard, Majid Karimi, Mohammad Hassan Baghaei, Pamela J Surkan, Majid Rahimi, Ahmad Esmaillzadeh, Walter C Willett

Abstract

Objective: To determine the effects of the Dietary Approaches to Stop Hypertension (DASH) eating pattern on cardiometabolic risks in type 2 diabetic patients.

Research design and methods: A randomized crossover clinical trial was undertaken in 31 type 2 diabetic patients. For 8 weeks, participants were randomly assigned to a control diet or the DASH eating pattern.

Results: After following the DASH eating pattern, body weight (P = 0.007) and waist circumference (P = 0.002) reduced significantly. Fasting blood glucose levels and A1C decreased after adoption of the DASH diet (-29.4 ± 6.3 mg/dl; P = 0.04 and -1.7 ± 0.1%; P = 0.04, respectively). After the DASH diet, the mean change for HDL cholesterol levels was higher (4.3 ± 0.9 mg/dl; P = 0.001) and LDL cholesterol was reduced (-17.2 ± 3.5 mg/dl; P = 0.02). Additionally, DASH had beneficial effects on systolic (-13.6 ± 3.5 vs. -3.1 ± 2.7 mmHg; P = 0.02) and diastolic blood pressure (-9.5 ± 2.6 vs. -0.7 ± 3.3 mmHg; P = 0.04).

Conclusions: Among diabetic patients, the DASH diet had beneficial effects on cardiometabolic risks.

References

    1. Kalofoutis C, Piperi C, Kalofoutis A, Harris F, Phoenix D, Singh J: Type II diabetes mellitus and cardiovascular risk factors: current therapeutic approaches. Exp Clin Cardiol 2007;12:17–28
    1. Vollmer WM, Sacks FM, Ard J, Appel LJ, Bray GA, Simons-Morton DG, Conlin PR, Svetkey LP, Erlinger TP, Moore TJ, Karanja NDASH-Sodium Trial Collaborative Research Group Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial. Ann Intern Med 2001;135:1019–1028
    1. Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, Fonseca V, Gerstein HC, Grundy S, Nesto RW, Pignone MP, Plutzky J, Porte D, Redberg R, Stitzel KF, Stone NJAmerican Heart Association, American Diabetes Association Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation 2007;115:114–126
    1. Azadbakht L, Mirmiran P, Esmaillzadeh A, Azizi T, Azizi F: Beneficial effects of a Dietary Approaches to Stop Hypertension eating plan on features of the metabolic syndrome. Diabetes Care 2005;28:2823–2831
    1. Forman JP, Stampfer MJ, Curhan GC: Diet and lifestyle risk factors associated with incident hypertension in women. JAMA 2009;302:401–411
    1. Toledo E, de A Carmona-Torre F, Alonso A, Puchau B, Zulet MA, Martinez JA, Martinez-Gonzalez MA: Hypothesis-oriented food patterns and incidence of hypertension: 6-year follow-up of the SUN (Seguimiento Universidad de Navarra) prospective cohort. Public Health Nutr 2010;13:338–349
    1. Levitan EB, Wolk A, Mittleman MA: Consistency with the DASH diet and incidence of heart failure. Arch Intern Med. 2009;169:851–857
    1. Liese AD, Nichols M, Sun X, D'Agostino RB, Jr, Haffner SM: Adherence to the DASH Diet is inversely associated with incidence of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes Care 2009;32:1434–1436
    1. Fleiss JL: The Design and Analysis of Clinical Experiments. London, John Wiley and Sons, 1986, p. 263–271
    1. Harris TJ, Cook DG, Wicks PD, Cappuccio FP: Impact of the new American Diabetes Association and World Health Organisation diagnostic criteria for diabetes on subjects from three ethnic groups living in the UK. Nutr Metab Cardiovasc Dis 2000;10:305–309
    1. Anderson JW: Diabetes mellitus: medical nutrition therapy. In Modern Nutrition in Health and Disease. 10th ed Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ: Eds. Philadelphia, Lippincott Williams and Wilkins, 2006, p. 1051–1053
    1. Flood A, Mitchell N, Jaeb M, Finch EA, Laqua PS, Welsh EM, Hotop A, Langer SL, Levy RL, Jeffery RW: Energy density and weight change in a long-term weight-loss trial. Int J Behav Nutr Phys Act 2009;6:57.
    1. Zemel MB, Thompson W, Milstead A, Morris K, Campbell P: Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res 2004;12:582–590
    1. Azadbakht L, Atabak S, Esmaillzadeh A: Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clinical trial. Diabetes Care 2008;31:648–654
    1. Appel LJ, Sacks FM, Carey VJ, Obarzanek E, Swain JF, Miller ER, 3rd, Conlin PR, Erlinger TP, Rosner BA, Laranjo NM, Charleston J, McCarron P, Bishop LMOmniHeart Collaborative Research Group Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA 2005;294:2455–2464

Source: PubMed

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