Reversed dipper blood-pressure pattern is closely related to severe renal and cardiovascular damage in patients with chronic kidney disease

Cheng Wang, Jun Zhang, Xun Liu, Cuicui Li, Zengchun Ye, Hui Peng, Zhujiang Chen, Tanqi Lou, Cheng Wang, Jun Zhang, Xun Liu, Cuicui Li, Zengchun Ye, Hui Peng, Zhujiang Chen, Tanqi Lou

Abstract

Background: A non-dipper blood pressure (BP) pattern is very common in chronic kidney disease (CKD) patients and affects the progression and development of cardiovascular disease. However, data on the reversed dipper BP pattern on target-organ damage in Chinese CKD patients are lacking.

Methods: A total of 540 CKD patients were enrolled. Ambulatory blood pressure monitoring (ABPM), clinical BP, ultrasonographic assessment and other clinical data were collected. Univariate and multivariate analyses were used to ascertain the relationship between ABPM results and clinical parameters.

Results: A total of 21.9% CKD patients had a reversed dipper BP pattern, 42% of patients had a non-dipper BP pattern and 36.1% of patients had a dipper BP pattern. Patients with reversed dipper BP pattern had the worst renal function and most severe cardiovascular damages among these CKD patients (p<0.05). The estimated glomerular filtration rate (eGFR) and left ventricular mass index (LVMI) correlated significantly with the rate of decline of nocturnal BP. A reversed dipper BP pattern was an independent factor affecting kidney damage and left ventricular hypertrophy. Age, lower hemoglobin level, higher 24-h systolic BP from ABPM, and higher serum phosphate levels were independent associated with a reversed dipper BP pattern after multivariate logistic regression analyses.

Conclusion: The reversed dipper BP pattern is closely related to severe renal damage and cardiovascular injuries in CKD patients, and special attention should be given to these CKD patients.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1. Correlation of proteinuria and estimated…
Figure 1. Correlation of proteinuria and estimated glomerular filtration rate with the rate of decline of nocturnal blood pressure.
A: Correlation of proteinuria with the rate of decline of nocturnal systolic blood pressure. B: Correlation of proteinuria with the rate of decline of nocturnal diastolic blood pressure. C: Correlation of estimated glomerular filtration rate with the rate of decline of nocturnal systolic blood pressure. D: Correlation of estimated glomerular filtration rate with the rate of decline of nocturnal diastolic blood pressure (eGFR: estimated glomerular filtration rate).
Figure 2. Correlation of left ventricular mass…
Figure 2. Correlation of left ventricular mass index, E/A ratio and CIMT with the rate of decline of nocturnal blood pressure.
A: Correlation of left ventricular mass index with the rate of decline of nocturnal systolic blood pressure. B: Correlation of E/A ratio with the rate of decline of nocturnal systolic blood pressure. C: Correlation of CIMT with the rate of decline of nocturnal systolic blood pressure. D: Correlation of left ventricular mass index with the rate of decline of nocturnal diastolic blood pressure. E: Correlation of E/A ratio with the rate of decline of nocturnal diastolic blood pressure. F: Correlation of CIMT with the rate of decline of nocturnal diastolic blood pressure. (LVMI: left ventricular mass index LVMI; E :.early mitral inflow filling velocity, A: peak mitral filling velocity at atrial contraction; CIMT: carotid intima-media thickness).

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Source: PubMed

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