Effect of Home-Based High-Intensity Interval Training in Patients With Lacunar Stroke: A Randomized Controlled Trial

Rikke Steen Krawcyk, Anders Vinther, Nicolas Caesar Petersen, Jens Faber, Helle K Iversen, Thomas Christensen, Kate Lykke Lambertsen, Shazia Rehman, Tobias Wirenfeldt Klausen, Egill Rostrup, Christina Kruuse, Rikke Steen Krawcyk, Anders Vinther, Nicolas Caesar Petersen, Jens Faber, Helle K Iversen, Thomas Christensen, Kate Lykke Lambertsen, Shazia Rehman, Tobias Wirenfeldt Klausen, Egill Rostrup, Christina Kruuse

Abstract

Background: High-intensity interval training (HIIT) is superior to moderate-intensity continuous training in improving cardiorespiratory fitness in patients with cardiovascular disease, but is it safe, feasible and effective in patients with stroke? We investigated feasibility and effect of early, home-based HIIT in patients with lacunar stroke combined with usual care vs. usual care, only. Methods: Patients with minor stroke (severity: 55/58 point on the Scandinavian Stroke Scale) were randomized to HIIT or usual care in a randomized, controlled trial. We measured the following outcomes at baseline and post-intervention: cardiorespiratory fitness monitored as power output from the Graded Cycling Test with Talk Test (GCT-TT; primary outcome), physical activity, fatigue, depression, well-being, stress, cognition, endothelial function, blood pressure, body mass index, and biomarkers. Results: We included 71 patients (mean age 63.7 ± 9.2), 49 men, 31 in intervention group. Home-based HIIT was feasible with no reported adverse events in relation to the intervention. No significant change between the groups in GCT-TT power output was detected (p = 0.90). The change in time spent on vigorous-intensity activity was 2 h/week and 0.6 h/week, intervention and usual care, respectively (p = 0.045). There were no significant differences between groups in the remaining secondary outcomes. Conclusion: HIIT was feasible and safe in patients with lacunar stroke. Patients can engage early in home-based HIIT when involved in choosing exercise modality and guided by weekly motivational phone calls. Within 3 months, HIIT did, however, not yield effect on cardiorespiratory fitness. We await further evaluation of long-term effects of this intervention on continued regular physical exercise and cardiovascular event. Clinical Trial Registration: https://ichgcp.net/clinical-trials-registry/NCT02731235" title="See in ClinicalTrials.gov">NCT02731235.

Keywords: aerobic exercise; high-intensity interval training; home-based physical activity; lacunar stroke; secondary stroke prevention.

Figures

Figure 1
Figure 1
Flow diagram of the randomized controlled trial to investigate effect of home-based HIIT in patients with lacunar stroke.
Figure 2
Figure 2
Change in vigorous-intensity activity from baseline to the post-intervention assessment in both groups. The figure shows the number of patients in each group who either increased, did not change or reduced their time spent on vigorous-intensity activity from baseline to post-intervention assessment.
Figure 3
Figure 3
Self-reported adherence to physical activity. Percentages of patients in the intervention group and in the usual care group who adhered or did not adhere to the international recommendations on physical activity at baseline and at the post-intervention assessment. The patients were considered adherent if they performed vigorous-intensity activity (≥75 min per week), moderate-intensity activity (≥150 min per week), or an equivalent combination. The figure also shows the percentage of patients in the intervention group and in the usual care group who participated in any vigorous-intensity activity at baseline and at the post-intervention assessment.

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