Chorioamnionitis: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Alisa Kachikis, Linda O Eckert, Christie Walker, Azucena Bardají, Frederick Varricchio, Heather S Lipkind, Khady Diouf, Wan-Ting Huang, Ronald Mataya, Mustapha Bittaye, Clare Cutland, Nansi S Boghossian, Tamala Mallett Moore, Rebecca McCall, Jay King, Shuchita Mundle, Flor M Munoz, Caroline Rouse, Michael Gravett, Lakshmi Katikaneni, Kevin Ault, Nicola P Klein, Drucilla J Roberts, Sonali Kochhar, Nancy Chescheir, Brighton Collaboration Chorioamnionitis Working Group, Alisa Kachikis, Linda O Eckert, Christie Walker, Azucena Bardají, Frederick Varricchio, Heather S Lipkind, Khady Diouf, Wan-Ting Huang, Ronald Mataya, Mustapha Bittaye, Clare Cutland, Nansi S Boghossian, Tamala Mallett Moore, Rebecca McCall, Jay King, Shuchita Mundle, Flor M Munoz, Caroline Rouse, Michael Gravett, Lakshmi Katikaneni, Kevin Ault, Nicola P Klein, Drucilla J Roberts, Sonali Kochhar, Nancy Chescheir, Brighton Collaboration Chorioamnionitis Working Group

No abstract available

Keywords: Adverse event; Amnionitis; Case definition; Chorioamnionitis; Guidelines; Immunization; Intra-amniotic infection.

Conflict of interest statement

Nicola Klein reports research support from GlaxoSmithKline, Pfizer, Sanofi Pasteur, Merck & Co and Protein Science (now Sanofi Pasteur). Kevin Ault is on several data and safety committees for maternal immunization and drug treatment trials.

Figures

Fig. 1
Fig. 1
Placental anatomy in the context of intra-amniotic infections (See Section 1.3.4c). Reprinted with permission from Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med. 2000 May 18;342(20):1500–7 .
Fig. 2
Fig. 2
Flow diagram describing pathway for source identification.
Fig. 3
Fig. 3
Definitions synthesized for chorioamnionitis based on the systematic literature review. (Two definitions for clinical chorioamnionitis were developed to correlate with the more specific definition for intraamniotic infection (or “Triple I”) from the NICHD chorioamnionitis workship (Clinical definition A), and with the more sensitive Gibbs criteria for chorioamnioitis (Clinical definition B). Please see Section 1.3.4 for further details.)
Fig. 4
Fig. 4
Case definition for chorioamnionitis with levels 1–3 of certainty.

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