Croup Associated With SARS-CoV-2: Pediatric Laryngotracheitis During the Omicron Surge

Sujit Sharma, Beesan Agha, Carlos Delgado, Karen Walson, Charles Woods, Mark D Gonzalez, Robert Jerris, Gregory Sysyn, James Beiter, Satoshi Kamidani, Christina A Rostad, Sujit Sharma, Beesan Agha, Carlos Delgado, Karen Walson, Charles Woods, Mark D Gonzalez, Robert Jerris, Gregory Sysyn, James Beiter, Satoshi Kamidani, Christina A Rostad

Abstract

In this retrospective analysis, we describe weekly croup and corresponding viral prevalence patterns in a pediatric quaternary care system in metropolitan Atlanta. We characterize a series of 24 patients with croup associated with SARS-CoV-2 infection and show that this clinical presentation increased substantially in frequency during the period of high Omicron vs Delta transmission.

Keywords: COVID-19; SARS-CoV-2; children; croup; tissue adaptation; tropism.

© The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society.

Figures

Figure 1.
Figure 1.
Patterns of weekly ED visits with croup diagnosis and corresponding weekly virus prevalence in a pediatric quaternary care system. January 4, 2021 to January 2, 2022. Abbreviation: ED, emergency department.
Figure 2.
Figure 2.
Frequency of laryngotracheitis (croup) among ED visits with COVID-19 diagnosis. Delta vs Omicron SARS-Cov-2 outbreaks within a pediatric quaternary care system. Abbreviation: ED, emergency department.

References

    1. Rihkanen H, Rönkkö E, Nieminen T, et al. . Respiratory viruses in laryngeal croup of young children. J Pediatr 2008; 152:661–5.
    1. Williams JV, Harris PA, Tollefson SJ, et al. . Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 2004; 350:443–50.
    1. Bjornson CL, Johnson DW.. Croup in children. CMAJ 2013; 185:1317–23.
    1. Pitstick CE, Rodriguez KM, Smith AC, Herman HK, Hays JF, Nash CB.. A curious case of croup: laryngotracheitis caused by COVID-19. Pediatrics 2021; 14:7.
    1. Tsoi K, Chan KC, Chan L, Mok G, Li AM, Lam HS.. A child with SARS-CoV2-induced croup. Pediatr Pulmonol 2021; 56:2377–8.
    1. Venn AMR, Schmidt JM, Mullan PC.. Pediatric croup with COVID-19. Am J Emerg Med 2021; 43:287.e1–3.
    1. Cassedy EA, Kim S, Silver AH.. An unexpected cause of croup in a pediatric patient. Clin Pediatr 2021; 60:574–6.
    1. Brewster RCL, Parsons C, Laird-Gion J, et al. . COVID-19-associated croup in children. Pediatrics 2022. doi:10.1542/peds.2022-056492
    1. CDC. COVID Data Tracker. Accessed January 25, 2022.
    1. Halfmann PJ, Iida S, Iwatsuki-Horimoto K, et al. . SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters. Nature 2022; 603:687–92.
    1. Lundberg AL, Lorenzo-Redondo R, Ozer EA, et al. . Has Omicron changed the evolution of the pandemic? JMIR Public Health Surveill 2022; 8:e35763.
    1. Hui KPY, Ho JCW, Cheung M-C, et al. . SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo. Nature 2022;603:715–20.
    1. Piersiala K, Kakabas L, Bruckova A, Starkhammar M, Cardell LO.. Acute odynophagia: a new symptom of COVID-19 during the SARS-CoV-2 Omicron variant wave in Sweden. J Intern Med 2022. :1–8.

Source: PubMed

Patrocinadores y Colaboradores

Condiciones médicas

Intervenciones de drogas

3
Suscribir