Effect of yoghurt containing Bifidobacterium lactis Bb12® on faecal excretion of secretory immunoglobulin A and human beta-defensin 2 in healthy adult volunteers

Jayakanthan Kabeerdoss, R Shobana Devi, R Regina Mary, D Prabhavathi, R Vidya, John Mechenro, N V Mahendri, Srinivasan Pugazhendhi, Balakrishnan S Ramakrishna, Jayakanthan Kabeerdoss, R Shobana Devi, R Regina Mary, D Prabhavathi, R Vidya, John Mechenro, N V Mahendri, Srinivasan Pugazhendhi, Balakrishnan S Ramakrishna

Abstract

Background: Probiotics are used to provide health benefits. The present study tested the effect of a probiotic yoghurt on faecal output of beta-defensin and immunoglobulin A in a group of young healthy women eating a defined diet.

Findings: 26 women aged 18-21 (median 19) years residing in a hostel were given 200 ml normal yoghurt every day for a week, followed by probiotic yoghurt containing Bifidobacterium lactis Bb12® (10⁹ in 200 ml) for three weeks, followed again by normal yoghurt for four weeks. Stool samples were collected at 0, 4 and 8 weeks and assayed for immunoglobulin A and human beta-defensin-2 by ELISA. All participants tolerated both normal and probiotic yoghurt well. Human beta-defensin-2 levels in faeces were not altered during the course of the study. On the other hand, compared to the basal sample, faecal IgA increased during probiotic feeding (P = 0.0184) and returned to normal after cessation of probiotic yoghurt intake.

Conclusions: Bifidobacterium lactis Bb12® increased secretory IgA output in faeces. This property may explain the ability of probiotics to prevent gastrointestinal and lower respiratory tract infections.

Figures

Figure 1
Figure 1
Box and whiskers plots showing the effect of probiotic yoghurt containing Bifidobacterium lactis Bb12® on faecal excretion of secretory IgA and human beta-defensin-2. The middle line represents the median, the box represents the interquartile range and the whiskers represent the total range. Faecal IgA excretion significantly increased during after probiotic yoghurt feeding and returned to normal levels after cessation of the probiotic.

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Source: PubMed

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