Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children

Abstract

Objective: To find the best lead exposure assessment marker for children.

Methods: We recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level.

Results: Nine of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score.

Conclusion: Lead exposure at younger age significantly impacts a child's later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.

Figures

Figure 1

Current blood lead level versus CBLI 1. Correlation coefficient: 0.600 (p = 0.067). (Outlier ID #54 removed). The two curved lines represent the 95% confidence interval.

Figure 2

Full-scale IQ score versus CBLI 1. Correlation coefficient: 0.823 (p = 0.006). (Outlier ID #54 removed). The two curved lines represent the 95% confidence interval.