Comparing the effects of two different contact lenses on corneal re-epithelialization after corneal collagen cross-linking

Yusuf Kocluk, Savas Cetinkaya, Emine Alyamac Sukgen, Murat Günay, Alper Mete, Yusuf Kocluk, Savas Cetinkaya, Emine Alyamac Sukgen, Murat Günay, Alper Mete

Abstract

Objective: To investigate whether keratoconus (KC) patients who applied the corneal collagen cross-linking (CXL) and two different contact lens (CL) showed any differences in complaints and findings following the CXL.

Methods: This prospective, comparative, double-blind clinical study involved 60 eyes of 60 patients (38 female and 22 male). At the end of the CXL procedure, CL (Balafilcon A) was inserted in 29 patients (Group-1) while CL with different material content (Hioxifilcon A) designed for therapeutic/bandage purposes were inserted in 31 patients (Group-2).

Results: On the 1st and 3th day after the CXL, there were no statistically significant differences between the groups in terms of the postoperative symptoms. On the 3th day after the CXL, all cases of both two groups were found to complete the corneal re-epithelialization. There was more PE ratio in the patients who had allergic conjunctivitis.

Conclusions: With the use of Balafilcon A and Hioxifilcon A lens materials, KC patients who underwent the CXL were found to have similar symptoms and clinical findings after the CXL. However, epithelial staining and PE were observed more in KC cases accompanied by allergic conjunctivitis.

Keywords: Allergic conjunctivitis; Bandage contact lens; Corneal collagen cross-linking; Corneal re-epithelialization; Keratoconus.

Conflict of interest statement

Declaration of interest: All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

References

    1. Alhayek A, Lu PR. Corneal collagen crosslinking in keratoconus and other eye disease. Int J Ophthalmol. 2015;8(2):407–418. doi:10.3980/j.issn.2222-3959.2015.02.35.
    1. Kok YO, Tan GF, Loon SC. Review: keratoconus in Asia. Cornea. 2012;31:581–593. doi:10.1097/ICO.0b013e31820cd61d.
    1. Romero-Jimenez M, Santodomingo-Rubido J, Wolffsohn JS. Keratoconus: a review. Cont Lens Anterior Eye. 2010;33:157–166. doi:10.1016/j.clae.2010.04.006.
    1. Li G, Fan ZJ, Peng XJ. Corneal collagen crosslinking for corneal ectasia of post-LASIK: one-year results. Int J Ophthalmol. 2012;5(2):190–195. doi:10.3980/j.issn.2222-3959.2012.02.15.
    1. Kymionis GD, Mikropoulos DG, Portaliou DM, Voudouragkaki IC, Kozobolis VP, Konstas AG. An overview of corneal collagen cross-linking (CXL) Adv Ther. 2013;30:858–869. doi:10.1007/s12325-013-0065-9.
    1. Blake CR, Cervantes-Casta˜neda RA, Macias-Rodríguez Y, Anzoulatous G, Ander-son R, Chayet AS. Comparison of postoperative pain in patients following photorefractive keratectomy versus advanced surface ablation. J Cataract Refract Surg. 2005;31:1314–1319. doi:10.1016/j.jcrs.2004.11.046.
    1. Grentzelos MA, Plainis S, Astyrakakis NI, Diakonis VF, Kymionis GD, Kallinikos P, et al. Efficacy of 2 types of silicone hydrogel bandage contact lenses after photorefractive keratectomy. J Cataract Refract Surg. 2009;35:2103–2108. doi:10.1016/j.jcrs.2009.07.015.
    1. Qu XM, Dai JH, Jiang ZY, Qian YF. Clinic study on silicone hydrogel contact lenses used as bandage contact lenses after LASEK surgery. Int J Ophthalmol. 2011;4(3):314–318. doi:10.3980/j.issn.2222-3959.2011.03.22.
    1. Plaka A, Grentzelos MA, Astyrakakis NI, Kymionis GD, Pallikaris IG, Plainis S. Efficacy of two silicone-hydrogel contact lenses for bandage use after photorefractive keratectomy. Cont Lens Anterior Eye. 2013;36:243–246. doi:10.1016/j.clae.2013.02.015.
    1. Wollensak G, Spoerl E, Seiler T. Riboflavin/ ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620–627. doi:10.1016/S0002-9394(02)02220-1.
    1. Boxer Wachler BS, Pinelli R, Ertan A, Chan CCK. Safety and efficacy of transepi-thelial crosslinking (C3-R/CXL) J Cataract Refract Surg. 2010;36:186–189. doi:10.1016/j.jcrs.2009.08.019.
    1. Segal O, Barkana Y, Hourovitz D, Behrman S, Kamun Y, Avni I, et al. Scleral contact lenses may help where other modalities fail. Cornea. 2003;22:308–310.
    1. Ehrlich DP. Therapeutic contact lenses. Optom Today. 2006;14:22–25.
    1. Rosenthal P, Cotter JM, Baum JL. Treatment of persistent corneal epithelial defects with extended wear of a fluid-ventilated gas permeable scleral contact lens. Am J Ophthalmol. 2000;130:33–41.
    1. Dart JK, Radford CF, Minassian D, Verma S, Stapleton F. Risk factors for microbial keratitis with contemporary contact lenses: a case-control study. Ophthalmology. 2008;115:1647–1654. doi:10.1016/j.ophtha.2008.05.003.
    1. Szczotka-Flynn L, Diaz M. Risk of corneal inflammatory events with silicone hydrogel and low Dk hydrogel extended contact lens wear: a meta-analysis. Optom Vis Sci. 2007;84:247–256. doi:10.1097/OPX.0b013e31816bf5a3.
    1. Schein OD, McNally J, Katz J, Chalmers RL, Tielsch JM, Alfonso E, et al. The incidence of microbial keratitis amoungst wearers of 30 day silicone hydrogel extended wear contact lenses. Ophthamol. 2005;112:2172–2179. doi:10.1016/j.ophtha.2005.09.014.
    1. Holden BA, Sankaridurg PR, Sweeney DF, Stretton S, Naduvilath TJ, Rao GN. Microbial keratitis in prospective studies of extended wear with disposable hydrogel contact lenses. Cornea. 2005;24:156–161.
    1. Engle AT, Laurent JM, Schallhorn SC, Toman SD, Newacheck JS, Tanzer DJ, et al. Masked comparison of silicone hydrogel lotrafilcon A and etafilcon A extended wear bandage contact lenses after photorefractive keratectomy. J Cataract Refract Surg. 2005;31:681–686. doi:10.1016/j.jcrs.2004.09.022.
    1. Edwards JD, Bower KS, Sediq DA, Burka JM, Stutzman RD, VanRoekel CR, et al. Effects of lotrafilcon A and omafilcon A bandage contact lenses on visual outcomes after photorefractive keratectomy. J Cataract Refract Surg. 2008;34:1288–1294. doi:10.1016/j.jcrs.2008.04.024.
    1. Gil-Cazorla R, Teus MA, Arranz-Marquez E. Comparison of silicone and nonsilicone hydrogel soft contact lenses used as a bandage after LASEK. J Refract Surg. 2008;24:199–203.
    1. Sun YZ, Guo L, Zhang FS. Curative effect assessment of bandage contact lens in neurogenic keratitis. Int J Ophthalmol. 2014;7(6):980–983. doi:10.3980/j.issn.2222-3959.2014.06.12.

Source: PubMed

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