Impaired cell surface expression and digestive function of sucrase-isomaltase gene variants are associated with reduced efficacy of low FODMAPs diet in patients with IBS-D
Diab M Husein, Hassan Y Naim, Diab M Husein, Hassan Y Naim
No abstract availableKeywords: enzyme function; intestinal function; irritable bowel syndrome; low FODMAP diet; protein trafficking; sucrase-isomaltase gene variants.
Conflict of interest statement
Competing interests: None declared.
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References
- Henström M, Diekmann L, Bonfiglio F, et al. . Functional variants in the sucrase–isomaltase gene associate with increased risk of irritable bowel syndrome. Gut 2018;67:263–70. 10.1136/gutjnl-2016-312456
- Zheng T, Eswaran S, Photenhauer AL, et al. . Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase (SI) hypomorphic variants. Gut 2019. 10.1136/gutjnl-2018-318036 . [Epub ahead of print: Jan 2019].
- Sperber AD, Dumitrascu D, Fukudo S, et al. . The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies: a Rome Foundation working team literature review. Gut 2017;66:1075–82. 10.1136/gutjnl-2015-311240
- Self MM, Czyzewski DI, Chumpitazi BP, et al. . Subtypes of irritable bowel syndrome in children and adolescents. Clin Gastroenterol Hepatol 2014;12:1468–73. 10.1016/j.cgh.2014.01.031
- Naim HY, Heine M, Zimmer K-P. Congenital sucrase-isomaltase deficiency: heterogeneity of inheritance, trafficking, and function of an intestinal enzyme complex. J Pediatr Gastroenterol Nutr 2012;55(Suppl 2):S13–20.
- Alfalah M, Jacob R, Preuss U, et al. . O-linked glycans mediate apical sorting of human intestinal sucrase-isomaltase through association with lipid rafts. Curr Biol 1999;9:593–6. 10.1016/S0960-9822(99)80263-2
Source: PubMed