Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase ( SI) hypomorphic variants

Tenghao Zheng, Shanti Eswaran, Amanda L Photenhauer, Juanita L Merchant, William D Chey, Mauro D'Amato, Tenghao Zheng, Shanti Eswaran, Amanda L Photenhauer, Juanita L Merchant, William D Chey, Mauro D'Amato

No abstract available

Keywords: carbohydrates; genetic polymorphisms; irritable bowel syndrome.

Conflict of interest statement

Competing interests: The project has been partially supported by an unrestricted research grant from QOL Medical to MD’A.

Figures

Figure 1
Figure 1
Decreased symptom relief in patients with IBS and diarrhoea carrying sucrase-isomaltase (SI) hypomorphic variants. Adequate symptom relief in low fermentable oligo-, di-, mono-saccharides and polyols treated individuals, stratified according to SI genotype into carriers and non-carriers of hypomorphic variants. *P=0.031 (one-tailed logistic regression analysis, adjusting for age, sex, body mass index and ethnicity).

References

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Source: PubMed

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