Electronic cigarettes in the USA: a summary of available toxicology data and suggestions for the future
Michael S Orr, Michael S Orr
Abstract
Objective: To review the available evidence evaluating the toxicological profiles of electronic cigarettes (e-cigarettes) in order to understand the potential impact of e-cigarettes on individual users and the public health.
Methods: Systematic literature searches were conducted between October 2012 and October 2013 using five electronic databases. Search terms such as 'e-cigarettes' and 'electronic delivery devices' were used to identify the toxicology information for e-cigarettes.
Results: As of October 2013, the scientific literature contains very limited information regarding the toxicity of e-cigarettes commercially available in the USA. While some preliminary toxicology data suggests that e-cigarette users are exposed to lower levels of toxicants relative to cigarette smokers, the data available is extremely limited at this time. At present, there is insufficient toxicological data available to perform thorough risk assessment analyses for e-cigarettes; few toxicology studies evaluating e-cigarettes have been conducted to date, and standard toxicological testing paradigms have not been developed for comparing disparate types of tobacco products such as e-cigarettes and traditional cigarettes.
Conclusions: Overall, the limited toxicology data on e-cigarettes in the public domain is insufficient to allow a thorough toxicological evaluation of this new type of tobacco product. In the future, the acquisition of scientific datasets that are derived from scientifically robust standard testing paradigms, include comprehensive chemical characterisation of the aerosol, provide information on users' toxicant exposure levels, and from studies replicated by independent researchers will improve the scientific community's ability to perform robust toxicological evaluations of e-cigarettes.
Keywords: Electronic nicotine delivery devices; Non-cigarette tobacco products; Toxicology.
References
- ISO 3308. Routine analytical cigarette-smoking machine—definitions and standard conditions. Geneva, Switzerland: International Organization for Standardization (ISO), 2000
- Determination of ‘Tar’, Nicotine and Carbon Monoxide in Mainstream Smoke. Ottowa, Canada: Health Canada Tobacco Control Programme, 1999
- The safety report on Ruyan e-cigarette and inhaled aerosol. Christchurch, New Zealand: Health New Zealand Ltd., 2008.
- Stepanov I, Jensen J, Hatsukami D, et al. Tobacco-specific nitrosamines in new tobacco products. Nicotine Tob Res 2006;8:309–13
- Fowles JR, Banton MI, Pottenger LH. A toxicological review of the propylene glycols. Crit Rev Toxicol 2013;43:363–90
- Goniewicz ML, Knysak J, Gawron M, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control 2014;23:133–9
- Bahl V, Lin S, Xu N, et al. Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. Reprod Toxicol 2012;34:529–37
- Farsalinos KE, Romagna G, Allifranchini E, et al. Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells. Int J Environ Res Public Health 2013;10:5146–62
- Romagna G, Allifranchini E, Bocchietto E, et al. Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke extract. Inhal Toxicol 2013;25:354–61
- U.S. Department of Health & Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis. Evaluation of E-cigarettes. St. Louis, MO: Food and Drug Administration, 2009.
- U.S. Federal Register. Code of Federal Regulations (annual edition). Title 21: Food and Drugs. Section 172.820 Polyethylene glycol (mean molecular weight 200-9,500). 1 April 2013. (accessed 1 Nov 2013)
- U.S. Federal Register. Harmful and potentially harmful constituents in tobacco products and tobacco smoke. Docket No. FDA-2012-N-0143, Volume 77, Number 64. 3 April 2012.
- Burstyn I. Peering through the mist: what does the chemistry of contaminants in electronic cigarettes tell us about the health risks? Philadelphia, PA: Drexel University School of Public Health, Department of Environmental and Occupational Health, 2013.
Source: PubMed