A Guide to Pain Assessment and Management in the Neonate

Norina Witt, Seth Coynor, Christopher Edwards, Hans Bradshaw, Norina Witt, Seth Coynor, Christopher Edwards, Hans Bradshaw

Abstract

Newborn infants experience acute pain with various medical procedures. Evidence demonstrates that controlling pain in the newborn period is beneficial, improving physiologic, behavioral, and hormonal outcomes. Multiple validated scoring systems exist to assess pain in a neonate; however, there is no standardized or universal approach for pain management. Healthcare facilities should establish a neonatal pain control program. The first step is to minimize the total number of painful iatrogenic events when possible. If a procedure cannot be avoided, a tiered approach to manage pain using environmental, non-pharmacologic, and pharmacologic modalities is recommended. This systematic approach should decrease acute neonatal pain, poor outcomes, and provider and parent dissatisfaction.

Keywords: Acetaminophen; Breastfeeding; Fentanyl; Glucose and sucrose; Ketamine; Morphine; Neonatal; Pain management; Topical and local anesthetics.

Figures

Fig. 1
Fig. 1
A tiered approach to analgesia in the neonate

References

    1. •• Lago P, Garetti E, Merazzi D, et al. Guidelines for procedural pain in the newborn. Acta Paediatr (Oslo, Norway: 1992). 2009;98(6):932–9. doi:10.1111/j.1651-2227.2009.01291.x. A foundational systematic review of procedural pain prevention and treatment of NICU neonatal patients.
    1. Anand KJ, Aranda JV, Berde CB, et al. Summary proceedings from the neonatal pain-control group. Pediatrics. 2006;117(3 Pt 2):S9–S22.
    1. Frunau RVE. Long-term consequences of pain in human neonates. In: Anand JKS, Stevens BJ, McGrath PJ, editors. Pain in neonates. 3. Amsterdam: Elsevier; 2007. pp. 55–76.
    1. Peterson BS, Vohr B, Staib LH, Cannistraci CJ, DOlberg A, Schenier KC, et al. Regional brain volume abnormalities and long-term cognitive outcome in preterm infants. JAMA. 2000;284:1939–1947. doi: 10.1001/jama.284.15.1939.
    1. Carbajal R, Rousset A, Danan C, Coquery S, Nolent P, Duerocq S, et al. Epidemiology and treatment of painful procedures in neonates in intensive care units. JAMA. 2008;300:60–70. doi: 10.1001/jama.300.1.60.
    1. Lago P, Guadagni AM, Merazzi D, Ancora G, Belleni CV, Cavazza A. Pain management in the neonatal intensive care unit: a national survey in Italy. Pediatr Anesth. 2005;15:925–931. doi: 10.1111/j.1460-9592.2005.01688.x.
    1. American Academy of Pediatrics Committee on Fetus and Newborn, American Academy of Pediatrics Section on Surgery, Canadian Paediatric Society Fetus and Newborn Committee et al. Prevention and management of pain in the neonate: an update. Pediatrics. 2006;118:2231. doi: 10.1542/peds.2006-2277.
    1. Koppal R, Ardash E, Uday A, Anilkumar G. Comparison of the midazolam transnasal atomizer and oral midazolam for sedative premedication in paediatric cases. J Clin Diagn Res. 2011;5(5):932–934.
    1. •• Fein JA, Zempsky WT, Cravero JP, The Committee on Pediatric Emergency Medicine and Section on Anesthesiology and Pain Medicine Pediatrics. Relief of pain and anxiety in pediatric patients in emergency medical systems. Pediatrics. 2012;130;e1391. doi:10.1542/peds.2012-2536. Excellent guideline demonstrating a systematic approach to assessment, treatment and prevention of pain in pediatric patients within the Emergency Department.
    1. Stevens BJ, Abbott LK, Yamada J, Harrison D, Stinson J, Taddio A, Barwick M, Latimer M, Scott SD, Rashotte J, Campbell F, Finley GA. CIHR team in children’s pain. epidemiology and management of painful procedures in children in canadian hospitals. CMAJ. 2011;183(7):E403–E410. doi: 10.1503/cmaj.101341.
    1. Karling M, Renström M, Ljungman G. Acute and postoperative pain in children: a Swedish nationwide survey. Acta Paediatr. 2002;91(6):660–666. doi: 10.1111/j.1651-2227.2002.tb03298.x.
    1. Carbajal R, Rousset A, Danan C, Coquery S, Nolent P, Ducrocq S, Saizou C, Lapillonne A, Granier M, Durand P, Lenclen R, Coursol A, Hubert P, de Saint Blanquat L, Boëlle PY, Annequin D, Cimerman P, Anand KJ, Bréart G. Epidemiology and treatment of painful procedures in neonates in intensive care units. JAMA. 2008;300(1):60–70. doi: 10.1001/jama.300.1.60.
    1. Joint Commission on Accreditation of Healthcare Organizations . Comprehensive accreditation manual for hospitals. Oakbrook Terrace: Joint Commission on Accreditation of Healthcare Organizations; 2001.
    1. Cohen LL, Lemanek K, Blount RL, et al. Evidence-based assessment of pediatric pain. J Pediatr Psychol. 2008;33(9):939–955. doi: 10.1093/jpepsy/jsm103.
    1. Jacob E. Pain assessment and management in children. In: Wong D, Hockenberry MJ, Wilson D, editors. Wong’s nursing care of infants and children. 9. St. Louis: Mosby; 2011. pp. 179–202.
    1. Beyer JE, Aradine CR. Content validity of an instrument to measure young children’s perceptions of the intensity of their pain. J Pediatr Nurs. 1986;1(6):386–395.
    1. Scott J, Huskisson EC. Graphic representation of pain. Pain. 1976;2(2):175–184. doi: 10.1016/0304-3959(76)90113-5.
    1. Hicks CL, von Baeyer CL, Spafford PA, vanKorlaar I, Goodenough B. The faces pain scale-revised: toward a common metric in pediatric pain measurement. Pain. 2001;93(2):173–183. doi: 10.1016/S0304-3959(01)00314-1.
    1. Belville RG, Seupaul RA. Pain measurement in pediatric emergency care: a review of the faces pain scale-revised. Pediatr Emerg Care. 2005;21(2):90–93. doi: 10.1097/01.pec.0000159051.26812.8b.
    1. Stinson JN, Kavanagh T, Yamada J, Gill N, Stevens B. Systematic review of the psychometric properties, interpretability and feasibility of self-report pain intensity measures for use in clinical trials in children and adolescents. Pain. 2006;125(1–2):143–157. doi: 10.1016/j.pain.2006.05.006.
    1. McGrath PJ, Walco GA, Turk DC, PedIMMPACT et al. Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendations. J Pain. 2008;9(9):771–783. doi: 10.1016/j.jpain.2008.04.007.
    1. Lawrence J, Alcock D, McGrath P, Kay J, MacMurray SB, Dulberg C. The development of a tool to assess neonatal pain. Neonatal Netw. 1993;12(6):59–66.
    1. Merkel SI, Voepel-Lewis T, Shayevitz JR, Malviya S. The FLACC: a behavioral scale for scoring postoperative pain in young children. Pediatr Nurs. 1997;23(3):293–297.
    1. Malviya S, Voepel-Lewis T, Tait AR, Merkel S, Tremper K, Naughton N. Depth of sedation in children undergoing computed tomography: validity and reliability of the University of Michigan Sedation Scale (UMSS) Br J Anaesth. 2002;88(2):241–245. doi: 10.1093/bja/88.2.241.
    1. Merkel S, Voepel-Lewis T, Malviya S. Pain assessment in infants and young children: the FLACC scale. Am J Nurs. 2002;102(10):55–58. doi: 10.1097/00000446-200210000-00024.
    1. Munro HM, Walton SR, Malviya S, et al. Low-dose ketorolac improves analgesia and reduces morphine requirements following posterior spinal fusion in adolescents. Can J Anaesth. 2002;49(5):461–466. doi: 10.1007/BF03017921.
    1. Riegger LQ, Voepel-Lewis T, Kulik TJ, et al. Albumin versus crystalloid prime solution for cardiopulmonary bypass in young children. Crit Care Med. 2002;30(12):2649–2654. doi: 10.1097/00003246-200212000-00007.
    1. Tait AR, Voepel-Lewis T, Robinson A, Malviya S. Priorities for disclosure of the elements of informed consent for research: a comparison between parents and investigators. Paediatr Anaesth. 2002;12(4):332–336. doi: 10.1046/j.1460-9592.2002.00851.x.
    1. Voepel-Lewis T, Merkel S, Tait AR, Trzcinka A, Malviya S. The reliability and validity of the face, legs, activity, cry, consolability observational tool as a measure of pain in children with cognitive impairment. Anesth Analg. 2002;95(5):1224–1229. doi: 10.1097/00000539-200211000-00020.
    1. Malviya S, Vopel-Lewis T, Burke C, et al. The revised FLACC observational pain tool: improved reliability and validity for pain assessment in children with cognitive impairment. Paediatr Anaesth. 2006;16:258–265. doi: 10.1111/j.1460-9592.2005.01773.x.
    1. Sharek PJ, Powers R, Koehn A, Anand KJ. Evaluation and development of potentially better practices to improve pain management of neonates. Pediatrics. 2006;118(Suppl 2):S78. doi: 10.1542/peds.2006-0913D.
    1. Blass E, Fitzgerald E, Kehoe P. Interactions between sucrose, pain and isolation distress. Pharmacol Biochem Behav. 1987;26:483–489. doi: 10.1016/0091-3057(87)90153-5.
    1. Blass EM, Shah A. Pain-reducing properties of sucrose in human newborns. Chem Sens. 1995;20:29–335. doi: 10.1093/chemse/20.1.29.
    1. Ren K, Blass EM, Zhou QQ, Dubner R. Suckling and sucrose ingestion suppress persistent hyperalgesia and spinal fos expression after forepaw inflammation in infant rats. Proc Natl Acad Sci USA. 1997;94:1471–1475. doi: 10.1073/pnas.94.4.1471.
    1. Stevens B, Yamada J, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2010;1:CD001069.
    1. Bueno M, Yamada J, Harrison D, et al. A systematic review and meta-analyses of nonsucrose sweet solutions for pain relief in neonates. Pain Res Manag. 2013;18(3):153–161. doi: 10.1155/2013/956549.
    1. Taddio A, Shah V, Hancock R, et al. Effectiveness of sucrose analgesia in newborns undergoing painful medical procedures. CMAJ. 2008;179:37. doi: 10.1503/cmaj.071734.
    1. Stevens B, Yamada J, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2004;3:CD001069.
    1. Johnston CC, Stremler R, Horton L, Friedman A. Effect of repeated doses of sucrose during heel stick procedure in preterm neonates. Biol Neonate. 1999;75:160. doi: 10.1159/000014092.
    1. Shah PS, Aliwalas LI, Shah V. Breastfeeding or breast milk for procedural pain in neonates. Cochrane Database Syst Rev. 2006;3:CD004950.
    1. Johnston C, Campbell-Yeo M, Fernandes A, Inglis D, Streiner D, Zee R. Skin-to-skin care for procedural pain in neonates. Cochrane Database Syst Rev. 2014
    1. Pillai Riddell RR, Racine NM, Turcotte K, et al. Non-pharmacological management of infant and young child procedural pain. Cochrane Database Syst Rev. 2011;10:CD006275.
    1. Campos RG. Soothing pain-elicited distress in infants with swaddling and pacifiers. Child Dev. 1989;60:781. doi: 10.2307/1131018.
    1. Campos RG. Rocking and pacifiers: two comforting interventions for heelstick pain. Res Nurs Health. 1994;17:321. doi: 10.1002/nur.4770170503.
    1. Bellieni CV, Bagnoli F, Perrone S, et al. Effect of multisensory stimulation on analgesia in term neonates. A randomized controlled trial. Pediatr Res. 2002;51:460–463. doi: 10.1203/00006450-200204000-00010.
    1. Bellieni CV, Buonocore G, Nenci A, Franci N, Cordelli DM, Bagnoli F. Sensorial Saturation: an effective analgesic tool for heel-prick in preterm infants. Biol Neonate. 2001;80(1):15–18. doi: 10.1159/000047113.
    1. Bellieni T, Coccina B. Sensorial saturation for infants’ pain. J Matern Fetal Neonatal Med. 2012;25:79–81. doi: 10.3109/14767058.2012.663548.
    1. Cignacco EL, Sellam G, Stoffel L, et al. Oral sucrose and “facilitated tucking” for repeated pain relief in preterms: a randomized controlled trial. Pediatrics. 2012;129:299. doi: 10.1542/peds.2011-1879.
    1. Gradin M, Finnstrom O, Schollin J. Feeding and oral glucose-additive effects on pain reduction in newborns. Early Hum Dev. 2004;77:57–65. doi: 10.1016/j.earlhumdev.2004.01.003.
    1. Chermont AG, Falcao LF, de Souza Silva EH, de Cassia Xavier Balda R, Guinsburg R. Skin-to-skin contact and/or oral 25% dextrose for procedural pain relief for term newborn infants. Pediatrics. 2009;124:e1101–e1107. doi: 10.1542/peds.2009-0993.
    1. Taddio A, Ohlsson A, Einarson TR, et al. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics. 1998;101:E1. doi: 10.1542/peds.101.2.e1.
    1. Kaur G, Gupta P, Kumar A. A randomized trial of eutectic mixture of local anesthetics during lumbar puncture in newborns. Arch Pediatr Adolesc Med. 2003;157:1065. doi: 10.1001/archpedi.157.11.1065.
    1. US Food and Drug Administration. FDA drug safety communication: reports of a rare, but serious and potentially fatal adverse effect with the use of over-the-counter (OTC) benzocaine gels and liquids applies to the gums or mouth.
    1. Taddio A, Ohlsson K, Ohlsson A. Lidocaine-prilocaine cream for analgesia during circumcision in newborn boys. Cochrane Database Syst Rev. 2000;2:CD000496.
    1. Roman- Rodriguez CF, Toussaint T, Sherlock DJ, et al. Pre-emptive penile ring block with sucrose analgesia reduces pain response to neonatal circumcision. Urology. 2014;83:893. doi: 10.1016/j.urology.2013.10.010.
    1. Shah V, Taddio A, Ohlsson A. Randomised controlled trial of paracetamol for heel prick pain in neonates. Arch Dis Child Fetal Neonatal Ed. 1998;79:F209. doi: 10.1136/fn.79.3.F209.
    1. Allegaert K, Palmer GM, Anderson BJ. The pharmacokinetics of intravenous paracetamol in neonates: size matters most. Arch Dis Child. 2011;96:575. doi: 10.1136/adc.2010.204552.
    1. • Cuzzolin L, Antonucci R, Fanos V. Paracetamol (acetaminophen efficacy and safety in the newborn. Curr Drug Metab. 2013;14:178. Quantifies the safe total daily dose of acetaminophen in the pre-term and term infants. Also, for infants 1–3 months of age, which had previously not been established.
    1. Trugo R, Anand KJ. Management of pain in the postoperative neonate. Clin Perinatol. 1989;16:61.
    1. Anderson BJ, Wollard GA, Holford NH. A model for size and age changes in the pharmacokinetics of paracetamol in neonates, infants and children. Br J Clin Pharmacol. 2000;5:125. doi: 10.1046/j.1365-2125.2000.00231.x.
    1. Ceelie I, de Wildt SN, van Dijk M, et al. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial. JAMA. 2013;309:149. doi: 10.1001/jama.2012.148050.
    1. • Anand KJ. Pain panacea for opiophobia in infants? JAMA. 2013;309:183. Reviews the above article by Ceelie (reference 62). Noting pros of the study, which included careful study design and well-matched study groups. Cons included small sample size, single-center study site, and lack of safety data. Further, he points out that there was only a brief duration of exposure to morphine 48–72 hours, which is the window in which opioid induced hyperalgesia could have increased analgesic requirements. Notes that there is a possibility of synergism between morphine and acetaminophen. Notes that infants are potentially less susceptible to hepatic toxicity from oral or rectal acetaminophen because of their slightly delayed maturation of cytochrome P450 enzyme and higher glutathione stores.
    1. Bhatt-Mehta V, Rosen DA. Management of acute pain in children. Clin Pharm. 1991;10:667.
    1. Zempsky WT, Bean-Lijewski J, Kauffman RE, et al. Needle-free powder lidocaine delivery system provides rapid effective analgesia for venipuncture or cannulation pain in children: randomized, double-blind comparison of venipuncture and venous cannulation pain after fast-onset needle free powder lidocaine or placebo treatment trial. Pediatrics. 2008;121:979. doi: 10.1542/peds.2007-0814.
    1. Carbajal R, Lenclen R, Jugie M, et al. Morphine does not provide adequate analgesia for acute procedural pain among preterm neonates. Pediatrics. 2005;115:1494. doi: 10.1542/peds.2004-1425.
    1. Taddio A, Lee C, Yip A, et al. Intravenous morphine and topical tetracaine for treatment of pain in neonates undergoing central line placement. JAMA. 2006;295:793. doi: 10.1001/jama.295.7.793.
    1. Pereira e Silva Y, Gomez RS, Marcatto Jde O, et al. Morphine versus remifentanil for intubating neonates. Arch Dis Child Fetal Neonatal Ed. 2007;92:F293. doi: 10.1136/adc.2006.105262.
    1. Saarenmaa E, Huttunen P, Leppaeluoto J, et al. Advantages of fentanyl over morphine in analgesia for ventilated newborn infants after birth: a randomized trial. J Pediatr. 1999;134:144. doi: 10.1016/S0022-3476(99)70407-5.
    1. Ionides SP, Weiss MG, Angelopoulos M, et al. Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation. J. Pediatr. 1994;125:113. doi: 10.1016/S0022-3476(94)70136-9.
    1. Franck LS, Vilardi J, Durand D, Powers R. Opioid withdrawal in neonates after continuous morphine or fentanyl during extracorporeal membrane oxygenation. Am J Crit Care. 1998;7:364.
    1. Anand KJ, Willson DF, Berger J, et al. Tolerance and withdrawal from prolonged opioid use in critically ill children. Pediatrics. 2010;125:e1208. doi: 10.1542/peds.2009-0489.
    1. Hall RW, Shbarou RM. Drugs of choice for sedation and analgesia in the neonatal ICU. Clin Perinatol. 2009;36:215. doi: 10.1016/j.clp.2009.04.001.
    1. Litman RS, Berkowitz RJ, Ward DS. Levels of consciousness and ventilatory parameters in young children during sedation with oral midazolam and nitrous oxide. Arch Pediatr Adolesc Med. 1996;150(7):671–675. doi: 10.1001/archpedi.1996.02170320017002.
    1. Saeerenmaa E, Neuvonen PJ, Huttunen P, Fellman V. Ketamine for procedural pain relief in newoborn infants. Arch Dis Child Fetal Neonatal Ed. 2001;85:F53. doi: 10.1136/fn.85.1.F53.
    1. Betremieux P, Carre P, Pladys P, et al. Doppler ultrasound assessment of the effects of ketamine on neonatal cerebral circulation. Dev Pharmacol Ther. 1993;20:9.
    1. Anand KJ, International Evidence-Based Group for Neonatal Pain Consensus statement for the prevention and management of pain in the newborn. Arch Pediatr Adolesc Med. 2001;155(2):173–180. doi: 10.1001/archpedi.155.2.173.
    1. Harlos MS, et al. Intranasal fentanyl in the palliative care of newborns and infants. J Pain Symptom Manag. 2013;46(2):265–274. doi: 10.1016/j.jpainsymman.2012.07.009.

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