Is prophylactic tranexamic acid administration effective and safe for postpartum hemorrhage prevention?: A systematic review and meta-analysis

Chunbo Li, Yuping Gong, Lingling Dong, Bingying Xie, Zhiyuan Dai, Chunbo Li, Yuping Gong, Lingling Dong, Bingying Xie, Zhiyuan Dai

Abstract

Background: To assess the efficacy and safety of tranexamic acid (TA) in reducing blood loss and lowering transfusion needs for patients undergoing caesarean section (CS) or vaginal delivery (VD).

Methods: An electronic literature search of PubMed, EMBASE, OVID, Cochrane library, Scopus, Central, and Clinical trials.gov was performed to identify studies that evaluating the usage of TA in CS or VD. The methodological quality of included trials was assessed and data extraction was performed.

Results: Finally, 25 articles with 4747 participants were included. Our findings indicated TA resulted in a reduced intra-, postoperative, and total blood loss by a mean volume of 141.25 mL (95% confidence interval [CI] -186.72 to -95.79, P < 0.00001), 36.42 mL (95% CI -46.50 to -26.34, P < 0.00001), and 154.25 mL (95% CI -182.04 to -126.47, P < 0.00001) in CS. TA administration in VD was associated with a reduced intra-, postoperative, and total blood loss by a mean volume of 22.88 mL (95% CI -50.54 to 4.77, P = 0.10), 41.24 mL (95% CI -55.50 to -26.98, P < 0.00001), and 84.79 mL (95% CI -109.93 to -59.65, P < 0.00001). In addition, TA could lower the occurrence rate of postpartum hemorrhage (PPH) and severe PPH, and reduce the risk of blood transfusions. No increased risk of deep vein thrombosis (DVT) after CS or VD was associated with TA usage, while the minor side effects were more common.

Conclusions: Our findings indicated that intravenous TA for patients undergoing CS was effective and safe. Although prophylactic TA administration is associated with reduced PPH, current existing data are insufficient to draw definitive recommendations about its clinical significance due to the poor to moderate quality of the included literatures. Thus, high-quality randomized controlled trials with larger samples are needed to validate our findings.

Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flowchart of the study selection.
Figure 2
Figure 2
The methodological quality of included trials.
Figure 3
Figure 3
Forest plot diagram showing the effect of tranexamic acid (TA) administration in cesarean section and vaginal delivery on total blood loss (A), intraoperative blood loss (B), and postoperative blood loss (C).
Figure 4
Figure 4
Forest plot diagram showing the effect of TA administration in cesarean section and vaginal delivery on the number of PPH (A), severe PPH (B), and transfusion needs (C). PPH = postpartum hemorrhage, TA = tranexamic acid.
Figure 5
Figure 5
Forest plot diagram showing the effect of TA administration in cesarean section and vaginal delivery on occurrence rate of DVT (A), and other minor adverse events (B). DVT = deep venous thrombosis, TA = tranexamic acid.
Figure 6
Figure 6
A funnel plot of the logarithm of effect size (RR) versus the SE for each study. RR = risk ratio, SE = standard error.

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Source: PubMed

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