Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine
Birgit Simell, Anu Nurkka, Mika Lahdenkari, Noga Givon-Lavi, Helena Käyhty, Ron Dagan, Jukka Jokinen, Birgit Simell, Anu Nurkka, Mika Lahdenkari, Noga Givon-Lavi, Helena Käyhty, Ron Dagan, Jukka Jokinen
Abstract
Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.
Figures
Probability (OR) of acquisition of pneumococcal carriage 1 month after immunization with one dose of 9-valent pneumococcal conjugate vaccine in association with postimmunization IgG (A), IgM (B), or MOPA (C). Pnc, S. pneumoniae.
Source: PubMed