Effectiveness of personal protective equipment in preventing severe acute respiratory syndrome coronavirus 2 infection among healthcare workers
Tetsuya Suzuki, Kayoko Hayakawa, Akira Ainai, Naoko Iwata-Yoshikawa, Kaori Sano, Noriyo Nagata, Tadaki Suzuki, Yuji Wakimoto, Yutaro Akiyama, Yusuke Miyazato, Keiji Nakamura, Satoshi Ide, Hidetoshi Nomoto, Takato Nakamoto, Masayuki Ota, Yuki Moriyama, Yuko Sugiki, Sho Saito, Shinichiro Morioka, Masahiro Ishikane, Noriko Kinoshita, Satoshi Kutsuna, Norio Ohmagari, Tetsuya Suzuki, Kayoko Hayakawa, Akira Ainai, Naoko Iwata-Yoshikawa, Kaori Sano, Noriyo Nagata, Tadaki Suzuki, Yuji Wakimoto, Yutaro Akiyama, Yusuke Miyazato, Keiji Nakamura, Satoshi Ide, Hidetoshi Nomoto, Takato Nakamoto, Masayuki Ota, Yuki Moriyama, Yuko Sugiki, Sho Saito, Shinichiro Morioka, Masahiro Ishikane, Noriko Kinoshita, Satoshi Kutsuna, Norio Ohmagari
Abstract
Introduction: Information on the effectiveness of personal protective equipment (PPE) for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among healthcare workers (HCWs), especially among HCWs with frequent contact with patients with SARS-CoV-2, is limited.
Methods: We conducted a prospective cohort study on 49 HCWs who worked in close contact with patients with SARS-CoV-2 infection. HCWs had blood samples taken every 2 weeks to test for SARS-CoV-2 antibodies using two different types of assay.
Results: Forty-nine participants (31 nurses, 15 doctors, 3 other workers) were enrolled. In total, 112 blood samples are obtained from participants. The median work days in 2 weeks was 9 (interquartile range (IQR): 5-10) days. In a single work day, 30 of the 49 participants (61.5%) had contact with patients with suspected or conformed SARS-CoV-2 at least 8 times, and approximately 60% of participants had more than 10 min of contact with a single patient. The median self-reported compliance to PPE was 90% (IQR: 80-100%). Seven participants tested positive for SARS-CoV-2 antibody using enzyme-linked immunosorbent assay (ELISA); however, none were seropositive for SARS-CoV-2 neutralizing antibody, so the positive ELISA results were assumed to be false-positive.
Conclusions: The study provides evidence that appropriate PPE is sufficient to prevent infection amongHCWs. It is necessary to establish a system that provides a stable supply of PPE for HCWs to perform their duties.
Keywords: COVID-19; Healthcare workers; Hospital-acquired infection; Personal protective equipment; SARS-CoV-2.
Conflict of interest statement
Declaration of competing interest None.
Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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Source: PubMed