Systematic review of the relationship between family history and lung cancer risk

A Matakidou, T Eisen, R S Houlston, A Matakidou, T Eisen, R S Houlston

Abstract

We performed a systematic review of 28 case-control, 17 cohort and seven twin studies of the relationship between family history and risk of lung cancer and a meta-analysis of risk estimates. Data from both case-control and cohort studies show a significantly increased lung cancer risk associated with having an affected relative. Risk appears to be greater in relatives of cases diagnosed at a young age and in those with multiple affected family members. Increased lung cancer risk was observed in association with an affected spouse and twin studies, while limited, favour shared environmental exposures. The limitations of the currently published epidemiological studies to infer genetic susceptibility are discussed.

Figures

Figure 1
Figure 1
Forrest plot of Relative risks (RR) of lung cancer in the case–control and cohort studies examining the relationship between family history and lung cancer risk, CI=confidence interval.
Figure 2
Figure 2
Forrest plot of familial lung cancer risks in never-smokers. RR=relative risks, CI= confidence interval.
Figure 3
Figure 3
Forrest plot of Relative risks (RR) of lung cancer associated with history of lung cancer in a spouse. CI=confidence interval.

References

    1. Ahlbom A, Lichtenstein P, Malmstrom H, Feychting M, Hemminki K, Pedersen NL (1997) Cancer in twins: genetic and nongenetic familial risk factors. J Natl Cancer Inst 89: 287–293
    1. Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain P, Schwartz AG, You M, Franklin W, Klein C, Gazdar A, Rothschild H, Mandal D, Coons T, Slusser J, Lee J, Gaba C, Kupert E, Perez A, Zhou X, Zeng D, Liu Q, Zhang Q, Seminara D, Minna J, Anderson MW (2004) A major lung cancer susceptibility locus maps to chromosome 6q23–25. Am J Hum Genet 75: 460–474
    1. Bradburn MJ, Deeks JJ, Altman DG (1999) Metan-an alternative meta-analysis command. In Stata Technical Bulletin, Vol. 8. Stata Corporation
    1. Braun MM, Ahlbom A, Floderus B, Brinton LA, Hoover RN (1995a) Effect of twinship on incidence of cancer of the testis, breast, and other sites (Sweden). Cancer Causes Control 6: 519–524
    1. Braun MM, Caporaso NE, Page WF, Hoover RN (1994) Genetic component of lung cancer: cohort study of twins. Lancet 344: 440–443
    1. Braun MM, Caporaso NE, Page WF, Hoover RN (1995b) A cohort study of twins and cancer. Cancer Epidemiol Biomarkers Prev 4: 469–473
    1. Bromen K, Pohlabeln H, Jahn I, Ahrens W, Jockel KH (2000) Aggregation of lung cancer in families: results from a population-based case–control study in Germany. Am J Epidemiol 152: 497–505
    1. Brownson RC, Alavanja MC, Caporaso N, Berger E, Chang JC (1997) Family history of cancer and risk of lung cancer in lifetime non-smokers and long-term ex-smokers. Int J Epidemiol 26: 256–263
    1. Cancer Research UK (2004a)
    1. Cannon-Albright LA, Thomas A, Goldgar DE, Gholami K, Rowe K, Jacobsen M, McWhorter WP, Skolnick MH (1994) Familiality of cancer in Utah. Cancer Res 54: 2378–2385
    1. Carmelli D, Swan GE, Robinette D, Fabsitz R (1992) Genetic influence on smoking – a study of male twins. N Engl J Med 327: 829–833
    1. Czene K, Lichtenstein P, Hemminki K (2002) Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database. Int J Cancer 99: 260–266
    1. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7: 177–188
    1. Doll R, Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66: 1191–1308
    1. Dong C, Hemminki K (2001) Modification of cancer risks in offspring by sibling and parental cancers from 2,112,616 nuclear families. Int J Cancer 92: 144–150
    1. Egger M, Davey SG, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629–634
    1. Etzel CJ, Amos CI, Spitz MR (2003) Risk for smoking-related cancer among relatives of lung cancer patients. Cancer Res 63: 8531–8535
    1. Gao YT, Blot WJ, Zheng W, Ershow AG, Hsu CW, Levin LI, Zhang R, Fraumeni Jr JF (1987) Lung cancer among Chinese women. Int J Cancer 40: 604–609
    1. Goldgar DE, Easton DF, Cannon-Albright LA, Skolnick MH (1994) Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst 86: 1600–1608
    1. Harvald B, Hauge M (1963) Heredity of cancer elucidated by a study of unselected twins. JAMA 186: 749–753
    1. Hemminki K, Dong C, Vaittinen P (2001a) Cancer risks to spouses and offspring in the Family-Cancer Database. Genet Epidemiol 20: 247–257
    1. Hemminki K, Li X (2002) Gender effects in familial cancer. Int J Cancer 102: 184–187
    1. Hemminki K, Li X (2003) Familial risk of cancer by site and histopathology. Int J Cancer 103: 105–109
    1. Hemminki K, Li X, Czene K (2004) Familial risk of cancer: data for clinical counseling and cancer genetics. Int J Cancer 108: 109–114
    1. Hemminki K, Lonnstedt I, Vaittinen P, Lichtenstein P (2001b) Estimation of genetic and environmental components in colorectal and lung cancer and melanoma. Genet Epidemiol 20: 107–116
    1. Hemminki K, Vaittinen P (1999) Familial cancers in a nationwide family cancer database: age distribution and prevalence. Eur J Cancer 35: 1109–1117
    1. Hemminki K, Vaittinen P, Kyyronen P (1998) Age-specific familial risks in common cancers of the offspring. Int J Cancer 78: 172–175
    1. Hemminki K, Vaittinen P, Kyyronen P (1999) Modification of cancer risk in offspring by parental cancer (Sweden). Cancer Causes Control 10: 125–129
    1. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539–1558
    1. Horwitz RI, Smaldone LF, Viscoli CM (1988) An ecogenetic hypothesis for lung cancer in women. Arch Intern Med 148: 2609–2612
    1. Hwang SJ, Cheng LS, Lozano G, Amos CI, Gu X, Strong LC (2003) Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk. Hum Genet 113: 238–243
    1. IARC (1986) Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Tobacco Smoking, Vol 38 Lyon: IARC
    1. IARC (2004) Monographs on the Evaluation of Carcinogenic Risks to Humans: Tobacco smoke and involuntary smoking IARC Monographs of the Evaluation of Carcinogenic Risks in Human Supplemenary, Vol 83, pp 1–1452. Lyon: IARC
    1. Jin YT, Xu YC, Yang RD, Huang CF, Xu CW, He XZ (2005) Familial aggregation of lung cancer in a high incidence area in China. Br J Cancer 92: 1321–1325
    1. Jonsson S, Thorsteinsdottir U, Gudbjartsson DF, Jonsson HH, Kristjansson K, Arnason S, Gudnason V, Isaksson HJ, Hallgrimsson J, Gulcher JR, Amundadottir LT, Kong A, Stefansson K (2004) Familial risk of lung carcinoma in the Icelandic population. JAMA 292: 2977–2983
    1. Kleinbaum DG, Krupper LL, Morgenstern H (1982) Epidemiologic Research. New York, NY: Van Nostrand Reinhold Co
    1. Kramer A, Graham S, Burnett W, Nasca P (1987) Familial aggregation of lung cancer stratified by smoking. Am J Epidemiol 126: 766 (abstract)
    1. Kreuzer M, Kreienbrock L, Gerken M, Heinrich J, Bruske-Hohlfeld I, Muller KM, Wichmann HE (1998) Risk factors for lung cancer in young adults. Am J Epidemiol 147: 1028–1037
    1. Li X, Hemminki K (2003) Familial and second lung cancers: a nation-wide epidemiologic study from Sweden. Lung Cancer 39: 255–263
    1. Li X, Hemminki K (2004) Inherited predisposition to early onset lung cancer according to histological type. Int J Cancer 112: 451–457
    1. Li X, Hemminki K (2005) Familial multiple primary lung cancers: a population-based analysis from Sweden. Lung Cancer 47: 301–307
    1. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K (2000) Environmental and heritable factors in the causation of cancer – analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 343: 78–85
    1. Liu ZY, He XZ, Chapman RS (1991) Smoking and other risk factors for lung cancer in Xuanwei, China. Int J Epidemiol 20: 26–31
    1. Lynch HT, Fain PR, Albano WA, Ruma T, Black L, Lynch J, Shonka M (1982) Genetic/epidemiological findings in a study of smoking-associated tumors. Cancer Genet Cytogenet 6: 163–169
    1. Macken LC, Yates B, Blancher S (2000) Concordance of risk factors in female spouses of male patients with coronary heart disease. J Cardiopulm Rehabil 20: 361–368
    1. Matakidou A, Eisen T, Bridle H, O'Brien M, Mutch R, Houlston RS (2005) Case–control study of familial lung cancer risks in UK women. Int J Cancer 116: 445–450
    1. Mayne ST, Buenconsejo J, Janerich DT (1999) Familial cancer history and lung cancer risk in United States nonsmoking men and women. Cancer Epidemiol Biomarkers Prev 8: 1065–1069
    1. McDuffie HH (1991) Clustering of cancer in families of patients with primary lung cancer. J Clin Epidemiol 44: 69–76
    1. McDuffie HH, Dosman JA, Klaassen DJ (1989) Cancer genes, agriculture. In Principles of Health and Safety in Agriculture Dosman JA, Cockcroft DW (eds) pp 258–261. Boca Raton, FL: CRC Press
    1. Ooi WL, Elston RC, Chen VW, Bailey-Wilson JE, Rothschild H (1986) Increased familial risk for lung cancer. J Natl Cancer Inst 76: 217–222
    1. Osann KE (1991) Lung cancer in women: the importance of smoking, family history of cancer, and medical history of respiratory disease. Cancer Res 51: 4893–4897
    1. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55: 74–108
    1. Pavlakou G, Tsarouha A, Koza M, Arvanitakis M, Antoniou D, Anagnostopoulou O (1993) Primary and secondary lung cancer in women: association of histological type with personal and family history. Eur Respir J 6: 291S
    1. Poole CA, Byers T, Calle EE, Bondy J, Fain P, Rodriguez C (1999) Influence of a family history of cancer within and across multiple sites on patterns of cancer mortality risk for women. Am J Epidemiol 149: 454–462
    1. Salber EJ, Macmahon B (1961) Cigarette smoking among high school students related to social class and parental smoking habits. Am J Public Health 51: 1780–1789
    1. Samet JM, Humble CG, Pathak DR (1986) Personal and family history of respiratory disease and lung cancer risk. Am Rev Respir Dis 134: 466–470
    1. Sanders BM, Jay M, Draper GJ, Roberts EM (1989) Non-ocular cancer in relatives of retinoblastoma patients. Br J Cancer 60: 358–365
    1. Schwartz AG, Rothrock M, Yang P, Swanson GM (1999) Increased cancer risk among relatives of nonsmoking lung cancer cases. Genet Epidemiol 17: 1–15
    1. Schwartz AG, Yang P, Swanson GM (1996) Familial risk of lung cancer among nonsmokers and their relatives. Am J Epidemiol 144: 554–562
    1. Sellers TA, Ooi WL, Elston RC, Chen VW, Bailey-Wilson JE, Rothschild H (1987) Increased familial risk for non-lung cancer among relatives of lung cancer patients. Am J Epidemiol 126: 237–246
    1. Shaw GL, Falk RT, Pickle LW, Mason TJ, Buffler PA (1991) Lung cancer risk associated with cancer in relatives. J Clin Epidemiol 44: 429–437
    1. Swift M, Chase C (1979) Cancer in families with xeroderma pigmentosum. J Natl Cancer Inst 62: 1415–1421
    1. Takemiya M, Shiraishi S, Teramoto T, Miki Y (1987) Bloom's syndrome with porokeratosis of Mibelli and multiple cancers of the skin, lung and colon. Clin Genet 31: 35–44
    1. Thompson SG (2001) Why and how sources of heterogeneity should be investigated. In Systematic Reviews in Health Care: Meta-Analysis in Context Egger M, Smith GD, Altman DG (eds) pp 157–175. London: BMJ Publishing Group
    1. Tokuhata GK, Lilienfeld AM (1963a) Familial aggregation of lung cancer among hospital patients. Public Health Rep 78: 277–283
    1. Tokuhata GK, Lilienfeld AM (1963b) Familial aggregation of lung cancer in humans. J Natl Cancer Inst 30: 289–312
    1. Tsugane S, Watanabe S, Sugimura H, Arimoto H, Shimosato Y, Suemasu K (1987) Smoking, occupation and family history in lung cancer patients under fifty years of age. Jpn J Clin Oncol 17: 309–317
    1. Verkasalo PK, Kaprio J, Koskenvuo M, Pukkala E (1999) Genetic predisposition, environment and cancer incidence: a nationwide twin study in Finland, 1976–1995. Int J Cancer 83: 743–749
    1. Wang TJ, Zhou BS, Shi JP (1996) Lung cancer in nonsmoking Chinese women: a case–control study. Lung Cancer 14(Suppl 1): S93–S98
    1. Wu AH, Fontham ET, Reynolds P, Greenberg RS, Buffler P, Liff J, Boyd P, Correa P (1996) Family history of cancer and risk of lung cancer among lifetime nonsmoking women in the United States. Am J Epidemiol 143: 535–542
    1. Wu AH, Yu MC, Thomas DC, Pike MC, Henderson BE (1988) Personal and family history of lung disease as risk factors for adenocarcinoma of the lung. Cancer Res 48: 7279–7284
    1. Wu PF, Lee CH, Wang MJ, Goggins WB, Chiang TA, Huang MS, Ko YC (2004) Cancer aggregation and complex segregation analysis of families with female non-smoking lung cancer probands in Taiwan. Eur J Cancer 40: 260–266
    1. Wunsch-Filho V, Boffetta P, Colin D, Moncau JE (2002) Familial cancer aggregation and the risk of lung cancer. Sao Paulo Med J 120: 38–44
    1. Wu-Williams AH, Dai XD, Blot W, Xu ZY, Sun XW, Xiao HP, Stone BJ, Yu SF, Feng YP, Ershow AG (1990) Lung cancer among women in north-east China. Br J Cancer 62: 982–987
    1. Yamanaka A, Hirai T, Ohtake Y, Kitagawa M (1997) Lung cancer associated with Werner's syndrome: a case report and review of the literature. Jpn J Clin Oncol 27: 415–418

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