Extensively drug-resistant tuberculosis in women, KwaZulu-Natal, South Africa

Max R O'Donnell, Jennifer Zelnick, Lise Werner, Iqbal Master, Marian Loveday, C Robert Horsburgh, Nesri Padayatchi, Max R O'Donnell, Jennifer Zelnick, Lise Werner, Iqbal Master, Marian Loveday, C Robert Horsburgh, Nesri Padayatchi

Abstract

To determine whether women in KwaZulu-Natal, South Africa, with drug-resistant tuberculosis (TB) were more likely than men to have extensively drug-resistant TB, we reviewed 4,514 adults admitted during 2003-2008 for drug-resistant TB. Female sex independently predicted extensively drug-resistant TB, even after we controlled for HIV infection. This association needs further study.

Figures

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Figure
Flow diagram for patients with multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) admitted to King George V Hospital, KwaZulu-Natal, South Africa, 2003–2008.

References

    1. World Health Organization. Global tuberculosis control—surveillance, planning, financing. Geneva: The Organization; 2010.
    1. Chaisson RE, Martinson NA. Tuberculosis in Africa—combating an HIV-driven crisis. N Engl J Med. 2008;358:1089–92. 10.1056/NEJMp0800809
    1. World Health Organization. Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010. global report on surveillance and response. Geneva: The Organization; 2010.
    1. Shisana O, Rehle T, Simbayi LC, Zuma K, Jooste S, Pillay-van-Wyk V, et al. South African national HIV prevalence, incidence, behaviour and communication survey 2008: a turning tide among teenagers? Cape Town (South Africa): HSRC Press; 2009.
    1. O’Donnell MR, Jarand J, Loveday M, Padayatchi N, Zelnick J, Werner L, et al. High incidence of hospital admissions with multidrug resistant and extensively drug resistant tuberculosis among South African health care workers. Ann Intern Med. 2010;153:516–22.
    1. O’Donnell MR, Padayatchi N, Master I, Osburn G, Horsburgh CR. Improved early results for patients with extensively drug-resistant tuberculosis and HIV in South Africa. Int J Tuberc Lung Dis. 2009;13:855–61.
    1. Gandhi NR, Shah NS, Andrews JR, Vella V, Moll AP, Scott M, et al. HIV coinfection in multidrug- and extensively drug-resistant tuberculosis results in high early mortality. Am J Respir Crit Care Med. 2010;181:80–6. 10.1164/rccm.200907-0989OC
    1. Dheda K, Shean K, Zumla A, Badri M, Streicher EM, Page-Shipp L, et al. Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study. Lancet. 2010;375:1798–807. 10.1016/S0140-6736(10)60492-8
    1. Heller T, Lessells RJ, Wallrauch CG, Bärnighausen T, Cooke GS, Mhlongo L, et al. Community-based treatment for multidrug-resistant tuberculosis in rural KwaZulu-Natal, South Africa. Int J Tuberc Lung Dis. 2010;14:420–6.
    1. Centers for Disease Control and Prevention. Notice to readers. Revised definition of extensively drug-resistant tuberculosis. MMWR Morb Mortal Wkly Rep. 2006;55:1176.
    1. Shah NS, Pratt R, Armstrong L, Robison V, Castro KG, Cegielski JP. Extensively drug-resistant tuberculosis in the United States, 1993–2007. JAMA. 2008;300:2153–60. 10.1001/jama.300.18.2153
    1. Mitnick CD, Shin SS, Seung KJ, Rich ML, Atwood SS, Furin JJ, et al. Comprehensive treatment of extensively drug-resistant tuberculosis. N Engl J Med. 2008;359:563–74. 10.1056/NEJMoa0800106
    1. Leimane V, Dravniece G, Riekstina V, Sture I, Kammerer S, Chen MP, et al. Treatment outcome of multidrug/extensively drug-resistant tuberculosis in Latvia, 2000–2004. Eur Respir J. 2010;36:584–93. 10.1183/09031936.00003710
    1. Shin SS, Pasechnikov AD, Gelmanova IY, Peremitin GG, Strelis AK, Mishustin S, et al. Treatment outcomes in an integrated civilian and prison MDR-TB treatment program in Russia. Int J Tuberc Lung Dis. 2006;10:402–8.
    1. Cox HS, Sibilia K, Feuerriegel S, Kalon S, Polonsky J, Khamraev AK, et al. Emergence of extensive drug resistance during treatment for multidrug-resistant tuberculosis. N Engl J Med. 2008;359:2398–400. 10.1056/NEJMc0805644

Source: PubMed

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