Optimization of sentinel lymph node biopsy in breast cancer using an operative gamma camera

Carole Mathelin, Samuel Salvador, Sabrina Croce, Norosoa Andriamisandratsoa, Daniel Huss, Jean-Louis Guyonnet, Carole Mathelin, Samuel Salvador, Sabrina Croce, Norosoa Andriamisandratsoa, Daniel Huss, Jean-Louis Guyonnet

Abstract

Background: Sentinel lymph node (SLN) procedure is now a widely accepted method of LN staging in selected invasive breast cancers (unifocal, size </= 2 cm, clinically N0, without previous treatment). Complete axillary clearance is no longer needed if the SLN is negative. However, the oncological safety of this procedure remains to be addressed in randomized clinical trials. One main pitfall is the failure to visualize SLN, resulting in incorrect tumor staging, leading to suboptimal treatment or axillary recurrence. Operative gamma cameras have therefore been developed to optimize the SLN visualization and the quality control of surgery.

Case presentation: A 44-year-old female patient with a 14-mm infiltrative ductal carcinoma underwent the SLN procedure. An operative gamma camera was used during and after the surgery. The conventional lymphoscintigraphy showed only one SLN, which was also detected by the operative gamma camera, then removed and measured (9.6 kBq). It was analyzed by frozen sections, showing no cancer cells. During this analysis, the exploration of the axillary area with the operative gamma camera enabled the identification of a second SLN with low activity (0.5 kBq) that conventional lymphoscintigraphy, surgical probe and blue staining had failed to visualize. Histological examination revealed a macrometastasis. Axillary clearance was then performed, followed by a postoperative image proving that no SLN remained. Therefore, the use of the operative gamma camera prevented an under-estimation of staging which would have resulted in a suboptimal treatment for this patient.

Conclusion: This case report illustrates that an efficient operative gamma camera may be able to decrease the risk of false negative rate of the SLN procedure, and could be an additional tool to control the quality of the surgery.

Trial registration: ClinicalTrials.gov Identifier: NCT00357487.

Figures

Figure 1
Figure 1
The anterior view of the conventional lymphoscintigraphy shows one SLN indicated by the yellow arrow. The purple arrow indicates the injection site.
Figure 2
Figure 2
Picture of the CarolIReS gamma camera built at the IPHC, Strasbourg, France.
Figure 3
Figure 3
Preoperative image of the axillary area obtained with the CarolIReS gamma camera. The x and y cumulative profiles (red stars) are used to determine the planar coordinates and the anatomical depth of the first SLN.
Figure 4
Figure 4
Peroperative image of the axillary area obtained with the CarolIReS gamma camera. The x and y cumulative profiles (red stars) are used to determine the planar coordinates and the anatomical depth of the second SLN.
Figure 5
Figure 5
Ductal breast carcinoma metastasis destroying nodal architecture (Hematoxilin and Eosin ×20). Inset: metastatic cells (Hematoxilin and Eosin ×200) in the second SLN.
Figure 6
Figure 6
Postoperative image of the axillary area obtained with the CarolIReS gamma camera.

References

    1. Veronesi U, Paganelli G, Galimberti V, Viale G, Zurrida S, Bedoni M, Costa A, de Cicco C, Geraghty JG, Luini A, Sacchini V, Veronesi P. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet. 1997;349:1864–1867. doi: 10.1016/S0140-6736(97)01004-0.
    1. Bleiweiss IJ. Sentinel lymph nodes in breast cancer after 10 years: rethinking basic principles. Lancet Oncol. 2006;7:686–692. doi: 10.1016/S1470-2045(06)70796-3.
    1. Leppanen E, Leidenius M, Krogerus L, von Smitten K. The effect of patient and tumour characteristics on visualization of sentinel nodes after a single intratumoural injection of Tc 99m labelled human albumin colloid in breast cancer. Eur J Surg Oncol. 2002;28:821–826. doi: 10.1053/ejso.2002.1325.
    1. Goyal A, Newcombe RG, Chhabra A, Mansel RE. Factors affecting failed localisation and false-negative rates of sentinel node biopsy in breast cancer--results of the ALMANAC validation phase. Breast Cancer Res Treat. 2006;99:203–208. doi: 10.1007/s10549-006-9192-1.
    1. Abe A, Takahashi N, Lee J, Oka T, Shizukuishi K, Kikuchi T, Inoue T, Jimbo M, Ryuo H, Bickel C. Performance evaluation of a hand-held, semiconductor (CdZnTe)-based gamma camera. Eur J Nucl Med Mol Imaging. 2003;30:805–811.
    1. Kopelman D, Blevis I, Iosilevsky G, Reznik A, Chaikov A, Weiner N, Israel O, Hashmonai M. A newly developed intra-operative gamma camera: performance characteristics in a laboratory phantom study. Eur J Nucl Med Mol Imaging. 2005;32:1217–1224. doi: 10.1007/s00259-005-1823-y.
    1. Mathelin C, Salvador S, Huss D, Guyonnet JL. Precise localization of sentinel lymph nodes and estimation of their depth using a prototype intraoperative mini gamma-camera in patients with breast cancer. J Nucl Med. 2007;48:623–629. doi: 10.2967/jnumed.106.036574.
    1. Motomura K, Noguchi A, Hashizume T, Hasegawa Y, Komoike Y, Inaji H, Saida T, Koyama H. Usefulness of a solid-state gamma camera for sentinel node identification in patients with breast cancer. J Surg Oncol. 2005;89:12–17. doi: 10.1002/jso.20162.
    1. Pitre S, Menard L, Ricard M, Solal M, Garbay JR, Charon Y. A hand-held imaging probe for radio-guided surgery: physical performance and preliminary clinical experience. Eur J Nucl Med Mol Imaging. 2003;30:339–343.
    1. Tsuchimochi M, Sakahara H, Hayama K, Funaki M, Ohno R, Shirahata T, Orskaug T, Maehlum G, Yoshioka K, Nygard E. A prototype small CdTe gamma camera for radioguided surgery and other imaging applications. Eur J Nucl Med Mol Imaging. 2003;30:1605–1614. doi: 10.1007/s00259-003-1301-3.
    1. NCT00357487 CTI. Evaluation of Two New Medical Instruments Dedicated to the Sentinel Lymph Node Technique in Case of Breast Cancer . 2006.
    1. Salvador S, Bekaert V, Mathelin C, Guyonnet JL, Huss D. An operative gamma camera for sentinel lymph node procedure in case of breast cancer. In: P07003 JINST, editor. JINST 2 P07003. 2007.
    1. Mathelin C, Piqueras I, Guyonnet JL. Performances of a new prototype handheld scintillating probe for the search of sentinel lymph nodes in breast cancer. Eur J Surg Oncol. 2006;32:24–28. doi: 10.1016/j.ejso.2005.09.017.
    1. McCready DR. Intraoperative sentinel node assessment is a touchy subject. Ann Surg Oncol. 2002;9:321–323.
    1. Goyal A, Newcombe RG, Mansel RE. Clinical relevance of multiple sentinel nodes in patients with breast cancer. Br J Surg. 2005;92:438–442. doi: 10.1002/bjs.4906.

Source: PubMed

Patrocinadores y Colaboradores

Condiciones médicas

Intervenciones de drogas

3
Suscribir