Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial
Andrew C Hoover, Mohammed M Milhem, Carryn M Anderson, Wenqing Sun, Brian J Smith, Henry T Hoffman, John M Buatti, Andrew C Hoover, Mohammed M Milhem, Carryn M Anderson, Wenqing Sun, Brian J Smith, Henry T Hoffman, John M Buatti
Abstract
Background: Adenoid cystic carcinomas (ACCs) are malignant salivary gland tumors noteworthy for high rates of late failure with limited salvage therapy options. We have previously shown increased Akt signaling is common in ACC and the human immunodeficiency virus (HIV) protease inhibitor nelfinavir (NFV) inhibits in vitro tumor growth by suppressing Akt signaling. This phase II trial was conducted to determine progression-free survival in response to NFV in patients with recurrent/endstage ACC who have failed standard therapies.
Methods: Eligible patients had recurrent or end-stage ACC and measureable disease per Response Evaluation Criteria in Solid Tumors (RECIST) criteria. NFV was provided at 1250 mg twice daily.
Results: Among 15 trial participants, median progression-free survival was 5.5 months (lower 95% bound 4.4 months). No patient achieved a RECIST partial or complete response to therapy.
Conclusion: NFV monotherapy does not result in a meaningful improvement in clinical outcomes among patients with recurrent ACC.
Keywords: Akt; adenoid cystic carcinoma; head and neck cancer; nelfinavir; salivary gland cancer.
© 2014 Wiley Periodicals, Inc.
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Source: PubMed