Long-Term, Prospective, Multicenter Study of Poly-4-Hydroxybutyrate Mesh (Phasix Mesh) for Hernia Repair in Cohort at Risk for Complication: 60-Month Follow-Up
John Scott Roth, Gary J Anthone, Don J Selzer, Benjamin K Poulose, Richard A Pierce, James G Bittner, William W Hope, Raymond M Dunn, Robert G Martindale, Matthew I Goldblatt, David B Earle, John R Romanelli, Gregory J Mancini, Jacob A Greenberg, John G Linn, Eduardo Parra-Davila, Bryan J Sandler, Corey R Deeken, Amit Badhwar, Jennifer L Salluzzo, Guy R Voeller, John Scott Roth, Gary J Anthone, Don J Selzer, Benjamin K Poulose, Richard A Pierce, James G Bittner, William W Hope, Raymond M Dunn, Robert G Martindale, Matthew I Goldblatt, David B Earle, John R Romanelli, Gregory J Mancini, Jacob A Greenberg, John G Linn, Eduardo Parra-Davila, Bryan J Sandler, Corey R Deeken, Amit Badhwar, Jennifer L Salluzzo, Guy R Voeller
Abstract
Background: Long-term resorbable mesh represents a promising technology for ventral and incisional hernia repair (VIHR). This study evaluates poly-4-hydroxybutyrate mesh (P4HB; Phasix Mesh) among comorbid patients with CDC class I wounds.
Study design: This prospective, multi-institutional study evaluated P4HB VIHR in comorbid patients with CDC class I wounds. Primary outcomes included hernia recurrence and surgical site infection. Secondary outcomes included pain, device-related adverse events, quality of life, reoperation, procedure time, and length of stay. Evaluations were scheduled at 1, 3, 6, 12, 18, 24, 30, 36, and 60 months. A time-to-event analysis (Kaplan-Meier) was performed for primary outcomes; secondary outcomes were reported as descriptive statistics.
Results: A total of 121 patients (46 male, 75 female) 54.7 ± 12.0 years old with a BMI of 32.2 ± 4.5 kg/m 2 underwent VIHR with P4HB Mesh (mean ± SD). Fifty-four patients (44.6%) completed the 60-month follow-up. Primary outcomes (Kaplan-Meier estimates at 60 months) included recurrence (22.0 ± 4.5%; 95% CI 11.7% to 29.4%) and surgical site infection (10.1 ± 2.8%; 95% CI 3.3 to 14.0). Secondary outcomes included seroma requiring intervention (n = 9), procedure time (167.9 ± 82.5 minutes), length of stay (5.3 ± 5.3 days), reoperation (18 of 121, 14.9%), visual analogue scale-pain (change from baseline -3.16 ± 3.35 cm at 60 months; n = 52), and Carolinas Comfort Total Score (change from baseline -24.3 ± 21.4 at 60 months; n = 52).
Conclusions: Five-year outcomes after VIHR with P4HB mesh were associated with infrequent complications and durable hernia repair outcomes. This study provides a framework for anticipated long-term hernia repair outcomes when using P4HB mesh.
Trial registration: ClinicalTrials.gov NCT01961687.
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Surgeons.
Figures
References
- Deeken CR, Matthews BD. Characterization of the mechanical strength, resorption properties, and histologic characteristics of a fully absorbable material (poly-4-hydroxybutyrate-PHASIX Mesh) in a porcine model of hernia repair. ISRN Surg. 2013;2013:238067.
- Dayton MT, Buchele BA, Shirazi SS, et al. . Use of an absorbable mesh to repair contaminated abdominal-wall defects. Arch Surg. 1986;121:954–960.
- Martin DP, Badhwar A, Shah DV, et al. . Characterization of poly-4-hydroxybutyrate mesh for hernia repair applications. J Surg Res. 2013;184:766–773.
- Instructions for Use - Phasix Mesh, C. R. Bard, Inc. (Warwick, RI). Available at: . Accessed June 5, 2022.
- Roth JS, Anthone GJ, Selzer DJ, et al. . Prospective evaluation of poly-4-hydroxybutyrate mesh in CDC class I/high-risk ventral and incisional hernia repair: 18-month follow-up. Surg Endosc. 2018;32:1929–1936.
- Roth JS, Anthone GJ, Selzer DJ, et al. . Prospective, multicenter study of P4HB (Phasix™) mesh for hernia repair in cohort at risk for complications: 3-year follow-up. Ann Med Surg (Lond). 2021;61:1–7.
- Plymale MA, Davenport DL, Dugan A, et al. . Ventral hernia repair with poly-4-hydroxybutyrate mesh. Surg Endosc. 2018;32:1689–1694.
- Messa CA, 4th, Kozak G, Broach RB, et al. . When the mesh goes away: an analysis of poly-4-hydroxybutyrate mesh for complex hernia repair. Plast Reconstr Surg Glob Open. 2019;7:e2576.
- Christopher AN, Patel V, Othman S, et al. . Onlay poly-4-hydroxybutyrate (P4HB) mesh for complex hernia: early clinical and patient reported outcomes. J Surg Res. 2021;264:199–207.
- Levy AS, Bernstein JL, Premaratne ID, et al. . Poly-4-hydroxybutyrate (Phasix) mesh onlay in complex abdominal wall repair. Surg Endosc. 2021;35:2014–2058.
- Buell JF, Sigmon D, Ducoin C, et al. . Initial experience with biologic polymer scaffold (poly-4-hydroxybuturate) in complex abdominal wall reconstruction. Ann Surg. 2017;266:185–188.
- Rognoni C, Cuccurullo D, Borsoi L, et al. . Clinical outcomes and quality of life associated with the use of a biosynthetic mesh for complex ventral hernia repair: analysis of the “Italian Hernia Club” registry. Sci Rep. 2020;10:10706.
- Pakula A, Skinner R. Outcomes of open complex ventral hernia repairs with retromuscular placement of poly-4-hydroxybutyrate bioabsorbable mesh. Surg Innov. 2020;27:32–37.
- Mellia JA, Othman S, Naga HI, et al. . Outcomes of poly-4-hydroxybutyrate mesh in ventral hernia repair: a systematic review and pooled analysis. Plast Reconstr Surg Glob Open. 2020;8:e3158.
- Centers for Disease Control and Prevention ( 2017. Surgical site infection protocol. Available at: . Accessed February 15, 2017.
- Mangram A, Horan T, Pearson M, et al. . Guideline for prevention of surgical site infection, 1999. Am J Infect Control. 2014;20:250–280.
- von Elm E, Altman DG, Egger M, et al. .; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370:1453–1457.
- Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–213.
- Burger JW, Luijendijk RW, Hop WC, et al. . Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia. Ann Surg. 2004;240:578–583; discussion 583.
- Kokotovic D, Bisgaard T, Helgstrand F. Long-term recurrence and complications associated with elective incisional hernia repair. JAMA. 2016;316:1575–1582.
- Buell J, Flaris A, Raju S, Hauch A, et al. . Long-term outcomes in complex abdominal wall reconstruction repaired with absorbable biologic polymer scaffold (poly-4-hydroxybutyrate). Ann Surg. 2021;1:1–7.
- Rosen MJ, Bauer JJ, Harmaty M, et al. . Multicenter, prospective, longitudinal study of the recurrence, surgical site infection, and quality of life after contaminated ventral hernia repair using biosynthetic absorbable mesh: the COBRA study. Ann Surg. 2017;265:205–211.
- Holihan JL, Nguyen DH, Nguyen MT, et al. . Mesh location in open ventral hernia repair: a systematic review and network meta-analysis. World J Surg. 2016;40:89–99.
- Otero J, Huber AT, Heniford BT. Laparoscopic hernia repair. Adv Surg. 2019;53:1–19.
- Schlosser KA, Maloney SR, Thielan O, et al. . Outcomes specific to patient sex after open ventral hernia repair. Surgery. 2020;167:614–619.
Source: PubMed