Exercise for Hypertension: A Prescription Update Integrating Existing Recommendations with Emerging Research

Linda S Pescatello, Hayley V MacDonald, Lauren Lamberti, Blair T Johnson, Linda S Pescatello, Hayley V MacDonald, Lauren Lamberti, Blair T Johnson

Abstract

Hypertension is the most common, costly, and preventable cardiovascular disease risk factor. Numerous professional organizations and committees recommend exercise as initial lifestyle therapy to prevent, treat, and control hypertension. Yet, these recommendations differ in the components of the Frequency, Intensity, Time, and Type (FITT) principle of exercise prescription (Ex Rx); the evidence upon which they are based is only of fair methodological quality; and the individual studies upon which they are based generally do not include people with hypertension, which are some of the limitations in this literature. The purposes of this review are to (1) overview the professional exercise recommendations for hypertension in terms of the FITT principle of Ex Rx; (2) discuss new and emerging research related to Ex Rx for hypertension; and (3) present an updated FITT Ex Rx for adults with hypertension that integrates the existing recommendations with this new and emerging research.

Keywords: Aerobic exercise; Blood pressure; Concurrent exercise; Postexercise hypotension; Prehypertension; Resistance exercise.

Figures

Fig. 1
Fig. 1
Flow diagram detailing the systematic search for potentially relevant reports (k) and the selection process of included meta-analyses (l) and exercise trials (n). CINAHL cumulative index to nursing and allied health literature. EMBASE–Excerpta Medica dataBASE. PEDro physiotherapy evidence database. RCTs—Randomized controlled trials. RE—Resistance exercise. a Indicates the databases that were searched in our previous systematic review to locate relevant meta-analyses; the complete search strategy is available from reference [••]. b Indicates the databases that were searched to locate potentially relevant exercise studies published since the ACSM position stand [6]; PubMed also includes the electronic database MEDLINE. Adapted from references [••, ••, ••]
Fig. 2
Fig. 2
Linear regression of the average blood pressure change from baseline following low, moderate, and vigorous intensity exercise. SBP systolic blood pressure. DBP diastolic blood pressure. VO2max maximum oxygen consumption. Black diamond suit indicates SBP, y = -14.9x + 14.0, R2 = 0.998. Black square indicates DBP, y = -5.9x–0.3, R2 = 0.969 (ps < 0.01). Adapted from reference [42]

References

    1. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation. 2015;131:e29–e322. doi: 10.1161/CIR.0000000000000152.
    1. Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123:933–44. doi: 10.1161/CIR.0b013e31820a55f5.
    1. Egan BM, Li J, Hutchison FN, Ferdinand KC. Hypertension in the United States, 1999 to 2012: Progress toward Healthy People 2020 goals. Circulation. 2014;130:1692–9. doi: 10.1161/CIRCULATIONAHA.114.010676.
    1. Johnson BT, MacDonald HV, Bruneau ML, Jr, Goldsby TU, Brown JC, Huedo-Medina TB, et al. Methodological quality of meta-analyses on the blood pressure response to exercise: a review. J Hypertens. 2014;32:706–23. doi: 10.1097/HJH.0000000000000097.
    1. Pescatello LS, MacDonald HV, Ash GI, Lambert LM, Farquhar WB, Arena R, et al. Assessing the existing professional exercise recommendations for hypertension: a review and recommendations for future research priorities. Mayo Clin Proc. 2015;90:801–12. doi: 10.1016/j.mayocp.2015.04.008.
    1. Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA, et al. American college of sports medicine position stand: exercise and hypertension. Med Sci Sports Exerc. 2004;36:533–53. doi: 10.1249/01.MSS.0000115224.88514.3A.
    1. Cornelissen VA, Fagard RH. Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension. 2005;46:667–75. doi: 10.1161/01.HYP.0000184225.05629.51.
    1. Cornelissen VA, Smart NA. Exercise training for blood pressure: a systematic review and meta-analysis. J Am Heart Assoc. 2013;2 doi: 10.1161/JAHA.112.004473.
    1. Kelley GA, Kelley KS. Progressive resistance exercise and resting blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2000;35:838–43. doi: 10.1161/01.HYP.35.3.838.
    1. Cornelissen VA, Fagard RH. Effect of resistance training on resting blood pressure: a meta-analysis of randomized controlled trials. J Hypertens. 2005;23:251–9. doi: 10.1097/00004872-200502000-00003.
    1. Cornelissen VA, Fagard RH, Coeckelberghs E, Vanhees L. Impact of resistance training on blood pressure and other cardiovascular risk factors: a meta-analysis of randomized, controlled trials. Hypertension. 2011;58:950–8. doi: 10.1161/HYPERTENSIONAHA.111.177071.
    1. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) JAMA. 2002;288:2981–97. doi: 10.1001/jama.288.23.2981.
    1. Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med. 2002;136:493–503. doi: 10.7326/0003-4819-136-7-200204020-00006.
    1. Brown RE, Riddell MC, Macpherson AK, Canning KL, Kuk JL. The joint association of physical activity, blood-pressure control, and pharmacologic treatment of hypertension for all-cause mortality risk. Am J Hypertens. 2013;26:1005–10. doi: 10.1093/ajh/hpt063.
    1. Naci H, Ioannidis JP. Comparative effectiveness of exercise and drug interventions on mortality outcomes: Metaepidemiological study. BMJ. 2013;347:f5577. doi: 10.1136/bmj.f5577.
    1. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jr, et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003;42:1206–52. doi: 10.1161/01.HYP.0000107251.49515.c2.
    1. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. Evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the eighth Joint National Committee (JNC 8) JAMA. 2014;311:507–20. doi: 10.1001/jama.2013.284427.
    1. Eckel RH, Jakicic JM, Ard JD, de Jesus JM, Houston Miller N, Hubbard VS, et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2014;63:2960–84. doi: 10.1016/j.jacc.2013.11.003.
    1. Brook RD, Appel LJ, Rubenfire M, Ogedegbe G, Bisognano JD, Elliott WJ, et al. Beyond medications and diet: alternative approaches to lowering blood pressure: a scientific statement from the American heart association. Hypertension. 2013;61:1360–83. doi: 10.1161/HYP.0b013e318293645f.
    1. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M, et al. 2013 ESH/ESC practice guidelines for the management of arterial hypertension. Blood Press. 2014;23:3–16. doi: 10.3109/08037051.2014.868629.
    1. Dasgupta K, Quinn RR, Zarnke KB, Rabi DM, Ravani P, Daskalopoulou SS, et al. The 2014 Canadian hypertension education program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension. Can J Cardiol. 2014;30:485–501. doi: 10.1016/j.cjca.2014.02.002.
    1. Pescatello LS. Exercise and hypertension: recent advances in exercise prescription. Curr Hypertens Rep. 2005;7:281–6. doi: 10.1007/s11906-005-0026-z.
    1. Pescatello LS, Arena R, Riebe D, Thompson PD. ACSM’s guidelines for exercise testing and prescription. 9. Baltimore: Lippincott Williams and Wilkins; 2013.
    1. Fitzgerald W. Labile hypertension and jogging: New diagnostic tool or spurious discovery? Br Med J (Clin Res Ed) 1981;282:542–4. doi: 10.1136/bmj.282.6263.542.
    1. Kenney MJ, Seals DR. Postexercise hypotension. Key features, mechanisms, and clinical significance. Hypertension. 1993;22:653–64. doi: 10.1161/01.HYP.22.5.653.
    1. Pescatello LS, Kulikowich JM. The aftereffects of dynamic exercise on ambulatory blood pressure. Med Sci Sports Exerc. 2001;33:1855–61. doi: 10.1097/00005768-200111000-00009.
    1. Quinn TJ. Twenty-four hour, ambulatory blood pressure responses following acute exercise: Impact of exercise intensity. J Hum Hypertens. 2000;14:547–53. doi: 10.1038/sj.jhh.1001106.
    1. Kraul J, Chrastek J, Adamirova J. The hypotensive effect of physical activity. In: Rabb W, editor. Prevention of ischemic heart disease: principles and practice. Springfield, IL: Charles C Thomas; 1966.
    1. Bennett T, Wilcox RG, Macdonald IA. Post-exercise reduction of blood pressure in hypertensive men is not due to acute impairment of baroreflex function. Clin Sci (Lond) 1984;67:97–103. doi: 10.1042/cs0670097.
    1. Brandao Rondon MU, Alves MJ, Braga AM, Teixeira OT, Barretto AC, Krieger EM, et al. Postexercise blood pressure reduction in elderly hypertensive patients. J Am Coll Cardiol. 2002;39:676–82. doi: 10.1016/S0735-1097(01)01789-2.
    1. Cleroux J, Kouame N, Nadeau A, Coulombe D, Lacourciere Y. Aftereffects of exercise on regional and systemic hemodynamics in hypertension. Hypertension. 1992;19:183–91. doi: 10.1161/01.HYP.19.2.183.
    1. Floras JS, Hara K. Sympathoneural and haemodynamic characteristics of young subjects with mild essential hypertension. J Hypertens. 1993;11:647–55. doi: 10.1097/00004872-199306000-00009.
    1. Floras JS, Sinkey CA, Aylward PE, Seals DR, Thoren PN, Mark AL. Postexercise hypotension and sympathoinhibition in borderline hypertensive men. Hypertension. 1989;14:28–35. doi: 10.1161/01.HYP.14.1.28.
    1. Wilcox RG, Bennett T, Brown AM, Macdonald IA. Is exercise good for high blood pressure? Br Med J (Clin Res Ed) 1982;285:767–9. doi: 10.1136/bmj.285.6344.767.
    1. Pescatello LS, Guidry MA, Blanchard BE, Kerr A, Taylor AL, Johnson AN, et al. Exercise intensity alters postexercise hypotension. J Hypertens. 2004;22:1881–8. doi: 10.1097/00004872-200410000-00009.
    1. Pescatello LS, Fargo AE, Leach CN, Jr, Scherzer HH. Short-term effect of dynamic exercise on arterial blood pressure. Circulation. 1991;83:1557–61. doi: 10.1161/01.CIR.83.5.1557.
    1. Wallace JP, Bogle PG, King BA, Krasnoff JB, Jastremski CA. The magnitude and duration of ambulatory blood pressure reduction following acute exercise. J Hum Hypertens. 1999;13:361–6. doi: 10.1038/sj.jhh.1000797.
    1. Paulev PE, Jordal R, Kristensen O, Ladefoged J. Therapeutic effect of exercise on hypertension. Eur J Appl Physiol Occup Physiol. 1984;53:180–5. doi: 10.1007/BF00422584.
    1. MacDonald JR, Hogben CD, Tarnopolsky MA, MacDougall JD. Post exercise hypotension is sustained during subsequent bouts of mild exercise and simulated activities of daily living. J Hum Hypertens. 2001;15:567–71. doi: 10.1038/sj.jhh.1001223.
    1. Hagberg JM, Montain SJ, Martin WH. Blood pressure and hemodynamic responses after exercise in older hypertensives. J Appl Physiol. 1987;63:270–6.
    1. Taylor-Tolbert NS, Dengel DR, Brown MD, McCole SD, Pratley RE, Ferrell RE, et al. Ambulatory blood pressure after acute exercise in older men with essential hypertension. Am J Hypertens. 2000;13:44–51. doi: 10.1016/S0895-7061(99)00141-7.
    1. Eicher JD, Maresh CM, Tsongalis GJ, Thompson PD, Pescatello LS. The additive blood pressure lowering effects of exercise intensity on post-exercise hypotension. Am Heart J. 2010;160:513–20. doi: 10.1016/j.ahj.2010.06.005.
    1. Pescatello LS. Effects of exercise on hypertension: From cells to physiological systems. In: Coleman WB, Tsongalis GJ, editors. Molecular and translational medicine. Switzerland: Springer International Publishing; 2015. pp. pp. 3–86.
    1. Liu S, Goodman J, Nolan R, Lacombe S, Thomas SG. Blood pressure responses to acute and chronic exercise are related in prehypertension. Med Sci Sports Exerc. 2012;44:1644–52. doi: 10.1249/MSS.0b013e31825408fb.
    1. Hecksteden A, Grutters T, Meyer T. Association between postexercise hypotension and long-term training-induced blood pressure reduction: a pilot study. Clin J Sport Med. 2013;23:58–63. doi: 10.1097/JSM.0b013e31825b6974.
    1. Haskell WL, Wolffe JB. Memorial lecture. Health consequences of physical activity: understanding and challenges regarding dose–response. Med Sci Sports Exerc. 1994;26:649–60. doi: 10.1249/00005768-199406000-00001.
    1. Bouchard C, Blair SN, Church TS, Earnest CP, Hagberg JM, Hakkinen K, et al. Adverse metabolic response to regular exercise: Is it a rare or common occurrence? PLoS One. 2012;7 doi: 10.1371/journal.pone.0037887.
    1. Luttrell MJ, Halliwill JR. Recovery from exercise: Vulnerable state, window of opportunity, or crystal ball? Front Physiol. 2015;6:204. doi: 10.3389/fphys.2015.00204.
    1. Molmen-Hansen HE, Stolen T, Tjonna AE, Aamot IL, Ekeberg IS, Tyldum GA, et al. Aerobic interval training reduces blood pressure and improves myocardial function in hypertensive patients. Eur J Prev Cardiol. 2012;19:151–60. doi: 10.1177/1741826711400512.
    1. Beck DT, Martin JS, Casey DP, Braith RW. Exercise training improves endothelial function in resistance arteries of young prehypertensives. J Hum Hypertens. 2014;28:303–9. doi: 10.1038/jhh.2013.109.
    1. Kessler HS, Sisson SB, Short KR. The potential for high-intensity interval training to reduce cardiometabolic disease risk. Sports Med. 2012;42:489–509. doi: 10.2165/11630910-000000000-00000.
    1. Swain DP, Franklin BA. Comparison of cardioprotective benefits of vigorous versus moderate intensity aerobic exercise. Am J Cardiol. 2006;97:141–7. doi: 10.1016/j.amjcard.2005.07.130.
    1. Tjonna AE, Lee SJ, Rognmo O, Stolen TO, Bye A, Haram PM, et al. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation. 2008;118:346–54. doi: 10.1161/CIRCULATIONAHA.108.772822.
    1. Weston KS, Wisloff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med. 2014;48:1227–34. doi: 10.1136/bjsports-2013-092576.
    1. Ciolac EG. High-intensity interval training and hypertension: Maximizing the benefits of exercise? Am J Cardiovasc Dis. 2012;2:102–10.
    1. Heydari M, Boutcher YN, Boutcher SH. High-intensity intermittent exercise and cardiovascular and autonomic function. Clin Auton Res. 2013;23:57–65. doi: 10.1007/s10286-012-0179-1.
    1. Gibala MJ, Little JP, Macdonald MJ, Hawley JA. Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol. 2012;590:1077–84. doi: 10.1113/jphysiol.2011.224725.
    1. Holloway TM, Bloemberg D, da Silva ML, Quadrilatero J, Spriet LL. High-intensity interval and endurance training are associated with divergent skeletal muscle adaptations in a rodent model of hypertension. Am J Physiol Regul Integr Comp Physiol. 2015;308:R927–34. doi: 10.1152/ajpregu.00048.2015.
    1. Holloway TM, Bloemberg D, da Silva ML, Simpson JA, Quadrilatero J, Spriet LL. High intensity interval and endurance training have opposing effects on markers of heart failure and cardiac remodeling in hypertensive rats. PLoS One. 2015;10 doi: 10.1371/journal.pone.0121138.
    1. Thompson PD, Franklin BA, Balady GJ, Blair SN, Corrado D, Estes NA, 3rd, et al. Exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the american heart association council on nutrition, physical activity, and metabolism and the council on clinical cardiology. Circulation. 2007;115:2358–68. doi: 10.1161/CIRCULATIONAHA.107.181485.
    1. Rognmo O, Moholdt T, Bakken H, Hole T, Molstad P, Myhr NE, et al. Cardiovascular risk of high- versus moderate-intensity aerobic exercise in coronary heart disease patients. Circulation. 2012;126:1436–40. doi: 10.1161/CIRCULATIONAHA.112.123117.
    1. Siscovick DS, Weiss NS, Fletcher RH, Lasky T. The incidence of primary cardiac arrest during vigorous exercise. N Engl J Med. 1984;311:874–7. doi: 10.1056/NEJM198410043111402.
    1. Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, et al. American college of sports medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43:1334–59. doi: 10.1249/MSS.0b013e318213fefb.
    1. Office of Disease Prevention and Health Promotion. 2008 physical activity guidelines for Americans. US Department of Health and Human Services. 2008.
    1. Jones H, Taylor CE, Lewis NC, George K, Atkinson G. Post-exercise blood pressure reduction is greater following intermittent than continuous exercise and is influenced less by diurnal variation. Chronobiol Int. 2009;26:293–306. doi: 10.1080/07420520902739717.
    1. Miyashita M, Burns SF, Stensel DJ. Accumulating short bouts of running reduces resting blood pressure in young normotensive/pre-hypertensive men. J Sports Sci. 2011;29:1473–82. doi: 10.1080/02640414.2011.593042.
    1. Lacombe SP, Goodman JM, Spragg CM, Liu S, Thomas SG. Interval and continuous exercise elicit equivalent postexercise hypotension in prehypertensive men, despite differences in regulation. Appl Physiol Nutr Metab. 2011;36:881–91. doi: 10.1139/h11-113.
    1. Padilla J, Wallace JP, Park S. Accumulation of physical activity reduces blood pressure in pre- and hypertension. Med Sci Sports Exerc. 2005;37:1264–75. doi: 10.1249/01.mss.0000175079.23850.95.
    1. Park S, Rink LD, Wallace JP. Accumulation of physical activity: blood pressure reduction between 10-min walking sessions. J Hum Hypertens. 2008;22:475–82. doi: 10.1038/jhh.2008.29.
    1. Park S, Rink LD, Wallace JP. Accumulation of physical activity leads to a greater blood pressure reduction than a single continuous session, in prehypertension. J Hypertens. 2006;24:1761–70. doi: 10.1097/01.hjh.0000242400.37967.54.
    1. Guidry MA, Blanchard BE, Thompson PD, Maresh CM, Seip RL, Taylor AL, et al. The influence of short and long duration on the blood pressure response to an acute bout of dynamic exercise. Am Heart J. 2006;151:1322–e5,1322.12. doi: 10.1016/j.ahj.2006.03.010.
    1. Ciolac EG, Guimaraes GV, D Avila VM, Bortolotto LA, Doria EL, Bocchi EA. Acute effects of continuous and interval aerobic exercise on 24-h ambulatory blood pressure in long-term treated hypertensive patients. Int J Cardiol. 2009;133:381–7. doi: 10.1016/j.ijcard.2008.02.005.
    1. Bhammar DM, Angadi SS, Gaesser GA. Effects of fractionized and continuous exercise on 24-h ambulatory blood pressure. Med Sci Sports Exerc. 2012;44:2270–6. doi: 10.1249/MSS.0b013e3182663117.
    1. Angadi SS, Weltman A, Watson-Winfield D, Weltman J, Frick K, Patrie J, et al. Effect of fractionized vs continuous, single-session exercise on blood pressure in adults. J Hum Hypertens. 2010;24:300–2. doi: 10.1038/jhh.2009.110.
    1. Harris KA, Holly RG. Physiological response to circuit weight training in borderline hypertensive subjects. Med Sci Sports Exerc. 1987;19:246–52. doi: 10.1249/00005768-198706000-00011.
    1. Norris R, Carroll D, Cochrane R. The effects of aerobic and anaerobic training on fitness, blood pressure, and psychological stress and well-being. J Psychosom Res. 1990;34:367–75. doi: 10.1016/0022-3999(90)90060-H.
    1. Blumenthal JA, Siegel WC, Appelbaum M. Failure of exercise to reduce blood pressure in patients with mild hypertension. Results of a randomized controlled trial. JAMA. 1991;266:2098–104. doi: 10.1001/jama.1991.03470150070033.
    1. Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, et al. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care. 2002;25:2335–41. doi: 10.2337/diacare.25.12.2335.
    1. Thomas GN, Hong AW, Tomlinson B, Lau E, Lam CW, Sanderson JE, et al. Effects of tai chi and resistance training on cardiovascular risk factors in elderly Chinese subjects: a 12-month longitudinal, randomized, controlled intervention study. Clin Endocrinol (Oxf) 2005;63:663–9. doi: 10.1111/j.1365-2265.2005.02398.x.
    1. Terra DF, Mota MR, Rabelo HT, Bezerra LM, Lima RM, Ribeiro AG, et al. Reduction of arterial pressure and double product at rest after resistance exercise training in elderly hypertensive women. Arq Bras Cardiol. 2008;91:299–305. doi: 10.1590/S0066-782X2008001700003.
    1. Jorge ML, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz AL, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism. 2011;60:1244–52. doi: 10.1016/j.metabol.2011.01.006.
    1. Park YH, Song M, Cho BL, Lim JY, Song W, Kim SH. The effects of an integrated health education and exercise program in community-dwelling older adults with hypertension: a randomized controlled trial. Patient Educ Couns. 2011;82:133–7. doi: 10.1016/j.pec.2010.04.002.
    1. Oliveira VN, Bessa A, Jorge MLMP, Oliveira RJS, de Mello MT, De Agostini GG, et al. The effect of different training programs on antioxidant status, oxidative stress, and metabolic control in type 2 diabetes. Appl Physiol Nutr Metab. 2012;37:334–44. doi: 10.1139/h2012-004.
    1. Mota MR, Oliveira RJ, Terra DF, Pardono E, Dutra MT, de Almeida JA, et al. Acute and chronic effects of resistance exercise on blood pressure in elderly women and the possible influence of ACE I/D polymorphism. Int J Gen Med. 2013;6:581–7.
    1. Moraes MR, Bacurau RF, Casarini DE, Jara ZP, Ronchi FA, Almeida SS, et al. Chronic conventional resistance exercise reduces blood pressure in stage 1 hypertensive men. J Strength Cond Res. 2012;26:1122–9. doi: 10.1519/JSC.0b013e31822dfc5e.
    1. Croymans DM, Krell SL, Oh CS, Katiraie M, Lam CY, Harris RA, et al. Effects of resistance training on central blood pressure in obese young men. J Hum Hypertens. 2014;28:157–64. doi: 10.1038/jhh.2013.81.
    1. Sarsan A, Ardic F, Ozgen M, Topuz O, Sermez Y. The effects of aerobic and resistance exercises in obese women. Clin Rehabil. 2006;20:773–82. doi: 10.1177/0269215506070795.
    1. Sillanpaa E, Hakkinen A, Punnonen K, Hakkinen K, Laaksonen DE. Effects of strength and endurance training on metabolic risk factors in healthy 40-65-year-old men. Scand J Med Sci Sports. 2009;19:885–95. doi: 10.1111/j.1600-0838.2008.00849.x.
    1. Shaw BS. Resting cardiovascular function improvements in adult men following resistance training. Afr J Phys Health Educ Recreat Dance. 2010;16:402–10.
    1. Nybo L, Sundstrup E, Jakobsen MD, Mohr M, Hornstrup T, Simonsen L, et al. High-intensity training versus traditional exercise interventions for promoting health. Med Sci Sports Exerc. 2010;42:1951–8. doi: 10.1249/MSS.0b013e3181d99203.
    1. Dolezal BA, Potteiger JA. Concurrent resistance and endurance training influence basal metabolic rate in nondieting individuals. J Appl Physiol. 1998;85:695–700.
    1. Leveritt M, Abernethy PJ, Barry B, Logan PA. Concurrent strength and endurance training: the influence of dependent variable selection. J Strength Cond Res. 2003;17:503–8.
    1. Keese F, Farinatti PV, Pescatello LS, Monteiro W. A comparison of the immediate effects of resistance, aerobic, and concurrent exercise on postexercise hypotension. J Strength Cond Res. 2011;25:1429–36. doi: 10.1519/JSC.0b013e3181d6d968.
    1. Hayashino Y, Jackson JL, Fukumori N, Nakamura F, Fukuhara S. Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. 2012;98:349–60. doi: 10.1016/j.diabres.2012.10.004.
    1. Borg GA. Perceived exertion. Exerc Sport Sci Rev. 1974;2:131–53. doi: 10.1249/00003677-197400020-00006.
    1. Borg G, Ljunggren G, Ceci R. The increase of perceived exertion, aches and pain in the legs, heart rate and blood lactate during exercise on a bicycle ergometer. Eur J Appl Physiol Occup Physiol. 1985;54:343–9. doi: 10.1007/BF02337176.
    1. US Preventive Services Task Force Procedure Manual. 2008. . Accessed September 11 2014.
    1. National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report. Obes Res. 1998;6 Suppl 2:51S-209S.
    1. Writing ESC guidelines: Recommendations for guidelines production. 2014. . Accessed September 11 2014.
    1. McAlister FA. The Canadian hypertension education program: a unique Canadian initiative. Can J Cardiol. 2006;22:559–64. doi: 10.1016/S0828-282X(06)70277-X.

Source: PubMed

3
Suscribir