The validity of self-reported medication adherence as an outcome in clinical trials of adherence-promotion interventions: Findings from the MACH14 study
Jane M Simoni, David Huh, Yan Wang, Ira B Wilson, Nancy R Reynolds, Robert H Remien, Kathy Goggin, Robert Gross, Marc I Rosen, Neil Schneiderman, Julia Arnsten, Carol E Golin, Judith A Erlen, David R Bangsberg, Honghu Liu, Jane M Simoni, David Huh, Yan Wang, Ira B Wilson, Nancy R Reynolds, Robert H Remien, Kathy Goggin, Robert Gross, Marc I Rosen, Neil Schneiderman, Julia Arnsten, Carol E Golin, Judith A Erlen, David R Bangsberg, Honghu Liu
Abstract
In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher's aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.
Source: PubMed