Preoperative REM Sleep Behavior Disorder and Subthalamic Nucleus Deep Brain Stimulation Outcome in Parkinson Disease 1 Year After Surgery
Elsa Besse-Pinot, Bruno Pereira, Franck Durif, Maria Livia Fantini, Elodie Durand, Bérengère Debilly, Philippe Derost, Caroline Moreau, Elodie Hainque, Tiphaine Rouaud, Alexandre Eusebio, Isabelle Benatru, Sophie Drapier, Dominique Guehl, Olivier Rascol, David Maltête, Ouhaïd Lagha-Boukbiza, Caroline Giordana, Melissa Tir, Stéphane Thobois, Lucie Hopes, Cécile Hubsch, Béchir Jarraya, Anne-Sophie Rolland, Jean-Christophe Corvol, David Devos, Ana Marques, Predistim Study Group, Dr Caroline Moreau, Pr Luc Defebvre, Dr Nicolas Carriere, Dr Guillaume Grolez, Dr Gillaume Baille, Dr Kreisler, Pr Jean-Pierre Pruvo, Pr Leclerc, Dr Renaud Lopes, Dr Romain Viard, Dr Gregory Kuchcinski, Mr Julien Dumont, Pr Kathy Dujardin, Mme M Delliaux, Mme M Brion, Dr Gustavo Touzet, Pr Nicolas Reyns, Pr Arnaud Delval, Mme Valerie Santraine, Mme Marie Pleuvret, Mme Nolwen Dautrevaux, Mr Victor Laugeais, Thavarak Ouk, Camille Potey, Celine Leclercq, Elise Gers, Alain Duhamel, Lynda Djemmane, Florence Duflot, Jean-Christophe Corvol Marie-Vidailhet, Elodie Hainque, Marie-Laure Welter, Lucette Lacomblez, David Grabli, Emmanuel Roze, Yulia Worbe, Cécile Delorme, Hana You, Jonas Ihle, Raquel GuimeraesCosta, Florence CormierDequaire, Aurélie Méneret, Andréas Hartmann, Louise-Laure Mariani, Stéphane Lehericy, Virginie Czernecki, Fanny Pineau, Frédérique Bozon, Camille Huiban, Eve Benchetrit, Carine Karachi, Soledad Navarro, Philippe Cornu, Arlette Welaratne, Lise Mantisi, Nathalie Jarry, Sophie Aix, Carine Lefort, Dr Tiphaine Rouaud, Pr Philippe Damier, Pr Pascal Derkinderen, Dr Anne-Gaelle Corbille, Dr Elisabeth CalvierAuffray, Laetitia Rocher, Anne-Laure Deruet, Dr Raoul Sylvie, Dr Roualdes Vincent, Le Dily Séverine, Dr Ana Marques, Dr Berangere Debilly, Pr Franck Durif, Dr Philippe Derost, Dr Charlotte Beal, Carine Chassain, Laure Delaby, Tiphaine Vidal, Pr Jean Jeacques Lemaire, Isabelle Rieu, Elodie Durand, Dr Drapier Sophie, Dr Frédérique Leh, Dr Alexandre Bonnet, Pr Marc Vérin, Dr Jean-Christophe Ferré, Jean François Houvenaghel, Pr Claire Haegelen, Francoise Kestens, Solenn Ory, Dr Caroline Girodana, Dr Claire Marsé, Dr Lydiane Mondot, Dr Bruno Giordana, Dr Robin Kardous, Bernadette Bailet, Héloise Joly, Dr Denys Fontaine, Dr Aurélie Leplus, Amélie Faustini, Vanessa Ferrier, Pr Pierre Burbaud, Dr Nathalie DamonPerriere, Pr Wassilios Meissner, Pr Francois Tison, Dr Stéphanie Bannier, Dr Elsa Krim, Pr Dominique Guehl, Dr Sandrine Molinier-Blossier, Dr Morgan Ollivier, Dr Marion Lacoste, Nicolas Auzou, Marie Bonnet, Pr Emmanuel Cuny, Dr Julien Engelhardt, Olivier Branchard, Clotilde Huet, Julie Blanchard, Pr Alexandre Eusebio, Pr Jean-Philippe Azulay, Dr Tatiana Witjas, Dr Frédérique Fluchère, Dr Stephan Grimaldi, Pr Nadine Girard, Eve Benchetrit, Marie Delfini, Dr Romain Carron, Pr Jean Regis, Dr Giorgio Spatola, Camille Magnaudet, Dr Ansquer Solène, Dr Benatru Isabelle, Dr Colin Olivier, Pr Houeto Jean Luc, Pr Guillevin Remy, Fradet Anne, Anziza Manssouri, Blondeau Sophie, Dr Richard Philippe, Dr Cam Philippe, Dr Page Philippe, Pr Bataille Benoit, Rabois Emilie, Guillemain Annie, Pr David Maltete, Dr Romain Lefaucheur, Dr Damien Fetter, Dr Nicolas Magne, Sandrine Bioux, Maud Loubeyre, Evangéline Bliaux, Dorothée Pouliquen, Pr Stéphane Derrey, Mme Linda Vernon, Dr Frédéric Ziegler, Pr Rascol Olivier, Dr Christine Brefel Courbon, Dr Fabienne Ory Magne, Dr Marion Simonetta Moreau, Pr Christophe Arbus, Pr Fabrice Bonneville, Dr Jean Albert Lotterie, Marion Sarrail, Pr Patrick Chaynes, Pr François Caire, Estelle Harroch, Pr Mathieu Anheim, Dr Ouhaid LaghaBoukbiza, Pr Christine Tranchant, Dr Odile Gebus, Dr Solveig Montaut, Dr Stéphane Kremer, Nadine Longato, Clélie Phillips, Dr Jimmy Voirin, Dr Marie des Neiges Santin, Dr Dominique Chaussemy, Dr Amaury Mengin, Pr Pierre Krystkowiak, Dr Mélissa Tir, Pr Jean-Marc Constans, Sandrine Wannepain, Audrey Seling, Dr Michel Lefranc, Stéphanie Blin, Béatrice Schuler, Pr Stephane Thobois, Dr Teodor Danaila, Dr Chloe Laurencin, Pr Yves Berthezene, Dr Roxana Ameli, Helene Klinger, Dr Gustavo Polo, Dr Emile Simon, Dr Patrick Mertens, A Nunes, Elise Metereau, Dr Lucie Hopes Dr, Emmanuelle Schmitt, Mylène Meyer, Céline Dillier, Pr Sophie Colnat, Anne Chatelain, Dr Jean- Philippe Brandel, Dr Cécile Hubsch, Dr Patte Karsenti, Dr Marie Lebouteux, Dr Marc Ziegler, Dr Christine Delmaire, Dr Julien Savatowky, Juliette Vrillac, Claire Nakache, Dr Vincent D'Hardemare, Lhaouas Belamri, Dr Frédérique Bourdain, Dr Vadim Afanassiev, Dr Philippe Graveleau, Dr Camille Decrocq, Dr Anne Boulin, Elodie Dupuy V, Dr Bérénice Gardel, Pr Béchir Jarraya, Delphine Lopez, Christophe Fruit, David Gay, Robin Bonice, Fouzia El Mountassir, Clara Fischer, Jean-François Mangin, Marie Chupin, Yann Cointepas, Bertrand Accart, Patrick Gelé, Florine Fievet, Matthieu Chabel, Virginie Derenaucourt, Loïc Facon, Yanick Tchantchou Njosse, Dominique Deplanque, Elsa Besse-Pinot, Bruno Pereira, Franck Durif, Maria Livia Fantini, Elodie Durand, Bérengère Debilly, Philippe Derost, Caroline Moreau, Elodie Hainque, Tiphaine Rouaud, Alexandre Eusebio, Isabelle Benatru, Sophie Drapier, Dominique Guehl, Olivier Rascol, David Maltête, Ouhaïd Lagha-Boukbiza, Caroline Giordana, Melissa Tir, Stéphane Thobois, Lucie Hopes, Cécile Hubsch, Béchir Jarraya, Anne-Sophie Rolland, Jean-Christophe Corvol, David Devos, Ana Marques, Predistim Study Group, Dr Caroline Moreau, Pr Luc Defebvre, Dr Nicolas Carriere, Dr Guillaume Grolez, Dr Gillaume Baille, Dr Kreisler, Pr Jean-Pierre Pruvo, Pr Leclerc, Dr Renaud Lopes, Dr Romain Viard, Dr Gregory Kuchcinski, Mr Julien Dumont, Pr Kathy Dujardin, Mme M Delliaux, Mme M Brion, Dr Gustavo Touzet, Pr Nicolas Reyns, Pr Arnaud Delval, Mme Valerie Santraine, Mme Marie Pleuvret, Mme Nolwen Dautrevaux, Mr Victor Laugeais, Thavarak Ouk, Camille Potey, Celine Leclercq, Elise Gers, Alain Duhamel, Lynda Djemmane, Florence Duflot, Jean-Christophe Corvol Marie-Vidailhet, Elodie Hainque, Marie-Laure Welter, Lucette Lacomblez, David Grabli, Emmanuel Roze, Yulia Worbe, Cécile Delorme, Hana You, Jonas Ihle, Raquel GuimeraesCosta, Florence CormierDequaire, Aurélie Méneret, Andréas Hartmann, Louise-Laure Mariani, Stéphane Lehericy, Virginie Czernecki, Fanny Pineau, Frédérique Bozon, Camille Huiban, Eve Benchetrit, Carine Karachi, Soledad Navarro, Philippe Cornu, Arlette Welaratne, Lise Mantisi, Nathalie Jarry, Sophie Aix, Carine Lefort, Dr Tiphaine Rouaud, Pr Philippe Damier, Pr Pascal Derkinderen, Dr Anne-Gaelle Corbille, Dr Elisabeth CalvierAuffray, Laetitia Rocher, Anne-Laure Deruet, Dr Raoul Sylvie, Dr Roualdes Vincent, Le Dily Séverine, Dr Ana Marques, Dr Berangere Debilly, Pr Franck Durif, Dr Philippe Derost, Dr Charlotte Beal, Carine Chassain, Laure Delaby, Tiphaine Vidal, Pr Jean Jeacques Lemaire, Isabelle Rieu, Elodie Durand, Dr Drapier Sophie, Dr Frédérique Leh, Dr Alexandre Bonnet, Pr Marc Vérin, Dr Jean-Christophe Ferré, Jean François Houvenaghel, Pr Claire Haegelen, Francoise Kestens, Solenn Ory, Dr Caroline Girodana, Dr Claire Marsé, Dr Lydiane Mondot, Dr Bruno Giordana, Dr Robin Kardous, Bernadette Bailet, Héloise Joly, Dr Denys Fontaine, Dr Aurélie Leplus, Amélie Faustini, Vanessa Ferrier, Pr Pierre Burbaud, Dr Nathalie DamonPerriere, Pr Wassilios Meissner, Pr Francois Tison, Dr Stéphanie Bannier, Dr Elsa Krim, Pr Dominique Guehl, Dr Sandrine Molinier-Blossier, Dr Morgan Ollivier, Dr Marion Lacoste, Nicolas Auzou, Marie Bonnet, Pr Emmanuel Cuny, Dr Julien Engelhardt, Olivier Branchard, Clotilde Huet, Julie Blanchard, Pr Alexandre Eusebio, Pr Jean-Philippe Azulay, Dr Tatiana Witjas, Dr Frédérique Fluchère, Dr Stephan Grimaldi, Pr Nadine Girard, Eve Benchetrit, Marie Delfini, Dr Romain Carron, Pr Jean Regis, Dr Giorgio Spatola, Camille Magnaudet, Dr Ansquer Solène, Dr Benatru Isabelle, Dr Colin Olivier, Pr Houeto Jean Luc, Pr Guillevin Remy, Fradet Anne, Anziza Manssouri, Blondeau Sophie, Dr Richard Philippe, Dr Cam Philippe, Dr Page Philippe, Pr Bataille Benoit, Rabois Emilie, Guillemain Annie, Pr David Maltete, Dr Romain Lefaucheur, Dr Damien Fetter, Dr Nicolas Magne, Sandrine Bioux, Maud Loubeyre, Evangéline Bliaux, Dorothée Pouliquen, Pr Stéphane Derrey, Mme Linda Vernon, Dr Frédéric Ziegler, Pr Rascol Olivier, Dr Christine Brefel Courbon, Dr Fabienne Ory Magne, Dr Marion Simonetta Moreau, Pr Christophe Arbus, Pr Fabrice Bonneville, Dr Jean Albert Lotterie, Marion Sarrail, Pr Patrick Chaynes, Pr François Caire, Estelle Harroch, Pr Mathieu Anheim, Dr Ouhaid LaghaBoukbiza, Pr Christine Tranchant, Dr Odile Gebus, Dr Solveig Montaut, Dr Stéphane Kremer, Nadine Longato, Clélie Phillips, Dr Jimmy Voirin, Dr Marie des Neiges Santin, Dr Dominique Chaussemy, Dr Amaury Mengin, Pr Pierre Krystkowiak, Dr Mélissa Tir, Pr Jean-Marc Constans, Sandrine Wannepain, Audrey Seling, Dr Michel Lefranc, Stéphanie Blin, Béatrice Schuler, Pr Stephane Thobois, Dr Teodor Danaila, Dr Chloe Laurencin, Pr Yves Berthezene, Dr Roxana Ameli, Helene Klinger, Dr Gustavo Polo, Dr Emile Simon, Dr Patrick Mertens, A Nunes, Elise Metereau, Dr Lucie Hopes Dr, Emmanuelle Schmitt, Mylène Meyer, Céline Dillier, Pr Sophie Colnat, Anne Chatelain, Dr Jean- Philippe Brandel, Dr Cécile Hubsch, Dr Patte Karsenti, Dr Marie Lebouteux, Dr Marc Ziegler, Dr Christine Delmaire, Dr Julien Savatowky, Juliette Vrillac, Claire Nakache, Dr Vincent D'Hardemare, Lhaouas Belamri, Dr Frédérique Bourdain, Dr Vadim Afanassiev, Dr Philippe Graveleau, Dr Camille Decrocq, Dr Anne Boulin, Elodie Dupuy V, Dr Bérénice Gardel, Pr Béchir Jarraya, Delphine Lopez, Christophe Fruit, David Gay, Robin Bonice, Fouzia El Mountassir, Clara Fischer, Jean-François Mangin, Marie Chupin, Yann Cointepas, Bertrand Accart, Patrick Gelé, Florine Fievet, Matthieu Chabel, Virginie Derenaucourt, Loïc Facon, Yanick Tchantchou Njosse, Dominique Deplanque
Abstract
Background and objectives: To determine whether patients with Parkinson disease (PD) eligible for subthalamic nucleus deep brain stimulation (STN-DBS) with probable REM sleep behavior disorder (RBD) preoperatively could be more at risk of poorer motor, nonmotor, and quality of life outcomes 12 months after surgery compared to those without RBD.
Methods: We analyzed the preoperative clinical profile of 448 patients with PD from a French multicentric prospective study (PREDISTIM) according to the presence or absence of probable RBD based on the RBD Single Question and RBD Screening Questionnaire. Among the 215 patients with PD with 12 months of follow-up after STN-DBS, we compared motor, cognitive, psycho-behavioral profile, and quality of life outcomes in patients with (pre-opRBD+) or without (pre-opRBD-) probable RBD preoperatively.
Results: At preoperative evaluation, pre-opRBD+ patients were older (61 ± 7.2 vs 59.5 ± 7.7 years; p = 0.02), had less motor impairment (Movement Disorder Society-sponsored version of the Unified Parkinson's Disease Rating Scale [MDS-UPDRS] III "off": 38.7 ± 16.2 vs 43.4 ± 7.1; p = 0.03) but more nonmotor symptoms on daily living activities (MDS-UPDRS I: 12.6 ± 5.5 vs 10.7 ± 5.3; p < 0.001), had more psychobehavioral manifestations (Ardouin Scale of Behavior in Parkinson's Disease total: 7.7 ± 5.1 vs 5.1 ± 0.4; p = 0.003), and had worse quality of life (Parkinson's Disease Questionnaire-39: 33 ± 12 vs 29 ± 12; p = 0.03), as compared to pre-opRBD- patients. Both pre-opRBD+ and pre-opRBD- patients had significant MDS-UPDRS IV score decrease (-37% and -33%, respectively), MDS-UPDRS III "med 'off'/stim 'on'" score decrease (-52% and -54%), and dopaminergic treatment decrease (-52% and -49%) after surgery, with no between-group difference. There was no between-group difference for cognitive and global quality of life outcomes.
Conclusions: In patients with PD eligible for STN-DBS, the presence of probable RBD preoperatively is not associated with a different clinical outcome 1 year after neurosurgery.
Trial registration information: NCT02360683.
Classification of evidence: This study provides Class II evidence that in patients with PD eligible for STN-DBS, the presence of probable RBD preoperatively is not associated with poorer outcomes 1 year post surgery.
© 2021 American Academy of Neurology.
Source: PubMed