5-azacitidine prolongs overall survival in patients with myelodysplastic syndrome--a systematic review and meta-analysis

Abstract

Hypomethylating agents have recently been shown to improve the outcome of patients with myelodysplastic syndrome. A meta-analysis and systematic review was carried out of randomized controlled trials comparing treatment with hypomethylating agents to conventional care, i.e., best supportive care or chemotherapy, in patients with myelodysplastic syndrome. The outcomes assessed were overall survival, time to transformation or death, overall response rate and toxicity. Hazard ratios with 95% confidence intervals were estimated and pooled for time-to-event data. For dichotomous data, relative risks were estimated and pooled. Four trials including 952 patients examined the effect of 5-azacitidine and decitabine. Treatment with hypomethylating agents significantly improved overall survival (hazard ratio 0.72, 95% confidence interval 0.60-0.85, three trials) and time to transformation or death (hazard ratio 0.69, 95% confidence interval 0.58-0.82, four trials). In a subgroup analysis per type of drug, these benefits could be shown for 5-azacitidine but not for decitabine. Both agents favorably influenced response rates. A higher rate of grade 3/4 adverse events was observed with their use. Since 5-azacitidine prolongs overall survival and time to transformation or death it should be highly considered in the treatment of patients with high-risk myelodysplastic syndrome. Further studies are needed to establish the exact role of decitabine compared to 5-azacitidine in these patients.

Figures

Figure 1.

Flow diagram: publications identified for study and exclusions.

Figure 2.

Overall survival in patients treated with hypomethylating agents as compared to best supportive care, low dose cytarabine (ARA C) or intensive chemotherapy.

Figure 3.

Time to AML or death in patients treated with hypomethylating agents as compared to conventional care.

Figure 4.

Overall response including complete response, partial response and haematologic improvement in patients treated with hypomethylating agents as compared to conventional care.