Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial

Abdoulie Bojang, Sarah L Baines, Bully Camara, Romain Guerillot, Liam Donovan, Raquel Sánchez Marqués, Ousman Secka, Umberto D'Alessandro, Christian Bottomley, Benjamin P Howden, Anna Roca, Abdoulie Bojang, Sarah L Baines, Bully Camara, Romain Guerillot, Liam Donovan, Raquel Sánchez Marqués, Ousman Secka, Umberto D'Alessandro, Christian Bottomley, Benjamin P Howden, Anna Roca

Abstract

In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx.

Clinical trials registration: NCT1800942.

Trial registration: ClinicalTrials.gov NCT01800942.

Keywords: ermC; msr(A); azithromycin; NPS; The Gambia.

© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

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Source: PubMed

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