Deep brain stimulation in the bed nucleus of the stria terminalis and medial forebrain bundle in a patient with major depressive disorder and anorexia nervosa

Patric Blomstedt, Matilda Naesström, Owe Bodlund, Patric Blomstedt, Matilda Naesström, Owe Bodlund

Abstract

Deep brain stimulation (DBS) may be considered in severe cases of therapy-refractory major depressive disorder (MDD). However, DBS for MDD is still an experimental therapy. Therefore, it should only be administered in clinical studies driven by multidisciplinary teams, including surgeons with substantial experience of DBS in the treatment of other conditions.

Keywords: Anorexia nervosa; bed nucleus of the stria terminalis; deep brain stimulation; depression; medial forebrain bundle.

Figures

Figure 1
Figure 1
Postoperative scans demonstrating the location of the electrodes: (A) CT coronal view; (B) CT sagittal view; (C) CT fused with T2 MRI at AC‐PC‐level with arrows indicating the electrodes in the BNST; (D) CT fused with T2 MRI 4 mm below AC‐PC‐level with arrows indicating the electrodes in the MFB. CT, computed tomography; MRI, magnetic resonance imaging; AC, anterior commissure; PC, posterior commissure; BNST, bed nucleus of stria terminalis; MFB, medial forebrain bundle.

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Source: PubMed

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