Risk scores for patients with chest pain: evaluation in the emergency department

B E Backus, A J Six, J H Kelder, W B Gibler, F L Moll, P A Doevendans, B E Backus, A J Six, J H Kelder, W B Gibler, F L Moll, P A Doevendans

Abstract

Chest pain is a common reason for presentation to the emergency department (ED). Absolute criteria for Acute Coronary Syndrome without ST elevation (NSTE-ACS) are lacking. An acute coronary syndrome (ACS) needs to be distinguished from a variety of other cardiac and non-cardiac diseases that may cause chest pain.For patients with confirmed ACS, several scoring methods can be applied in order to distinguish patients in the coronary care unit who may benefit most from therapies. The PURSUIT, TIMI, GRACE and FRISC risk scores are well validated with this respect. However, none of these risk scores has been used in the identification of an ACS in the emergency setting. The vast majority of patients with chest pain due to causes other than ACS were not evaluated in these trials. An evidence-based systematic stratification and policy for these patients does not currently exist.The more recently developed HEART score is specifically designed to stratify all chest pain patients in the ED. The HEART score was validated in a retrospective multicenter study and proved to be a strong predictor of event free survival on one hand and potentially life threatening cardiac events on the other hand. The HEART score facilitates risk stratification of chest pain patients in the ED.

Keywords: Chest pain; emergency department.; risk scores.

Figures

Fig. (1)
Fig. (1)
Probability of reaching a MACE in each HEART category [14].

References

    1. Lee TH, Goldman L. Evaluation of the patient with acute chest pain. N Engl J Med. 2000;342:1187–95.
    1. Bassand JP, Christian WH, Ardissino D, et al. ESC guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J. 2007;28:1598–660.
    1. Swap CJ, Nagurney JT. Value and limitations of chest pain history in the evaluation of patients with suspected acute coronary syndromes. JAMA. 2005;294:2623–29.
    1. Boersma E, Pieper KS, Steyerberg EW, et al. for the PURSUIT investigators. Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation. Results from an international trial of 9461 patients. Circulation. 2000;101:2557–67.
    1. Antman EM, Cohen Mk, Bernink PJLM, et al. The TIMI risk score for unstable angina/ non-ST elevation MI. JAMA. 2000;284:835–42.
    1. Araújo Gonçalves P, de Ferreira J, Aguiar C, Seabra-Gomes R. TIMI, PURSUIT, and GRACE risk scores: sustained prognostic value and interaction with revascularization in NSTE-ACS. Eur Heart J. 2005;26:865–72.
    1. Yan AT, Yan RT, Tan M, et al. Risk scores for risk stratification in acute coronary syndromes: useful but simpler is not necessarily better. Eur Heart J. 2007;28:1072.
    1. Ramsay G, Podogrodzka M, McClure C, Fox KAA. Risk prediction in patients presenting with suspected cardiac pain: The GRACE and TMI risk scores versus clinical evaluation. Q J Med. 2007;100:11–8.
    1. Granger CB, Goldberg RJ, Dabbous OH, et al. for the Global Registry of Acute Coronary Events Investigators. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163:2345–53.
    1. Fox KA, Dabbous OH, Goldberg RJ, et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE) BMJ. 2006;333:1091.
    1. Armstrong PW, Fu Y, Chang WC, et al. Acute coronary syndromes in the GUSTO-IIb Trial, prognostic insights and impact of recurrent ischemia. Circulation. 1998;98:1860–8.
    1. Lagerqvist B, Diderholm E, Lindahl B, et al. FRISC score for selection of patients for an early invasive treatment strategy in unstable coronary artery disease. Heart. 2005;91:1074–52.
    1. Six AJ, Backus BE, Kelder JC. Chest pain in the emergency room: value of the HEART score. Neth Heart J. 2008;16:191–6.
    1. Backus BE, Six AJ, Kelder JC, et al. Chest pain in the emergency room, a multicenter validation of the HEART score. Crit Pathw Cardiol. 2010;9:164–9.
    1. Morrow DA. Cardiovascular risk prediction in patients with stable and unstable coronary heart disease. Circulation. 2010;121:2681–91.

Source: PubMed

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