Continuous glucose monitoring in children with type 1 diabetes
Diabetes Research in Children Network (DirecNet) Study Group, Bruce Buckingham, Roy W Beck, William V Tamborlane, Dongyuan Xing, Craig Kollman, Rosanna Fiallo-Scharer, Nelly Mauras, Katrina J Ruedy, Michael Tansey, Stuart A Weinzimer, Tim Wysocki, Diabetes Research in Children Network (DirecNet) Study Group, Bruce Buckingham, Roy W Beck, William V Tamborlane, Dongyuan Xing, Craig Kollman, Rosanna Fiallo-Scharer, Nelly Mauras, Katrina J Ruedy, Michael Tansey, Stuart A Weinzimer, Tim Wysocki
Abstract
Objective: To examine the feasibility of daily use of a continuous glucose monitor, the FreeStyle Navigator Continuous Glucose Monitoring System ("Navigator"), in children with type 1 diabetes (T1D).
Study design: After a masked Navigator was used for 4 to 7 days to establish a baseline level of glycemic control, 30 insulin pump users with T1D (average age 11.2 years) were asked to use the Navigator daily for 13 weeks.
Results: Subjects averaged 149 h/wk of Navigator use during the first 4 weeks, which decreased slightly to 134 h/wk during weeks 9 to 13 (P = .006). Mean hemoglobin A1c improved from 7.1% at baseline to 6.8% at 13 weeks (P = .02), and the percentage of glucose values between 71 and 180 mg/dL increased from 52% to 60% (P = .01). Subjects and parents reported high satisfaction with the Navigator on the Continuous Glucose Monitor Satisfaction Scale. Two subjects had severe skin reactions related to sensor mount adhesive.
Conclusion: This study indicates that incorporating real-time continuous glucose monitoring into the daily treatment of children with T1D is feasible. The results provide a compelling rationale for conducting a randomized trial of daily use of a continuous glucose monitor in children with T1D.
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Source: PubMed