Incidental findings on brain magnetic resonance imaging of children with sickle cell disease
Lori C Jordan, Robert C McKinstry 3rd, Michael A Kraut, William S Ball, Bruce A Vendt, James F Casella, Michael R DeBaun, John J Strouse, Silent Infarct Transfusion Trial Investigators, Michele Afif, Gladstone Airewele, William S Ball Jr, Brian Berman, Francois Bernaudin, Ana Burgos, James F Casella, Charles Daeschner, Michael Dowling, Beng Fuh, Mario Grossi, Helge Hartung, Mark Heiny, Debra Hirtz, Joanna Howard, Thomas Howard, Rebecca Ichord, Baba Inusa, Rathi V Iyer, Karen Kalinyak, Allison King, Melanie Kirby-Allen, Fenella Kirkham, Michael Kraut, Janet Kwiatkowski, Robert C McKinstry 3rd, Caterina Minniti, Michael Noetzel, Charles T Quinn, Julie Panepinto, Mark Ranalli, Rupa Redding-Lallinger, Melissa Rhodes, E Steve Roach, Hernan Sabio, Suzanne Saccente, Sharada Sarnaik, John J Strouse, Paul Telfer, Alexis Thompson, Anthony Villella, Gerald Woods, Michael R DeBaun, Bruce Barton, Lori C Jordan, Robert C McKinstry 3rd, Michael A Kraut, William S Ball, Bruce A Vendt, James F Casella, Michael R DeBaun, John J Strouse, Silent Infarct Transfusion Trial Investigators, Michele Afif, Gladstone Airewele, William S Ball Jr, Brian Berman, Francois Bernaudin, Ana Burgos, James F Casella, Charles Daeschner, Michael Dowling, Beng Fuh, Mario Grossi, Helge Hartung, Mark Heiny, Debra Hirtz, Joanna Howard, Thomas Howard, Rebecca Ichord, Baba Inusa, Rathi V Iyer, Karen Kalinyak, Allison King, Melanie Kirby-Allen, Fenella Kirkham, Michael Kraut, Janet Kwiatkowski, Robert C McKinstry 3rd, Caterina Minniti, Michael Noetzel, Charles T Quinn, Julie Panepinto, Mark Ranalli, Rupa Redding-Lallinger, Melissa Rhodes, E Steve Roach, Hernan Sabio, Suzanne Saccente, Sharada Sarnaik, John J Strouse, Paul Telfer, Alexis Thompson, Anthony Villella, Gerald Woods, Michael R DeBaun, Bruce Barton
Abstract
Objective: We describe the prevalence and range of incidental intracranial abnormalities identified through MRI of the brain in a large group of children screened for a clinical trial.
Methods: We included 953 children between 5 and 14 years of age who were screened with MRI of the brain for the Silent Infarct Transfusion Trial. All had sickle cell anemia or sickle beta-null thalassemia. MRI scans were interpreted by 3 neuroradiologists. MRI scans reported to have any abnormality were reviewed by 2 study neuroradiologists. Incidental findings were classified into 4 categories, that is, no, routine, urgent, or immediate referral recommended. Cerebral infarctions and vascular lesions were not considered incidental and were excluded.
Results: We identified 63 children (6.6% [95% confidence interval: 5.1%-8.4%]) with 68 incidental intracranial MRI findings. Findings were classified as urgent in 6 cases (0.6%), routine in 25 cases (2.6%), and no referral required in 32 cases (3.4%). No children required immediate referral. Two children with urgent findings underwent surgery in the subsequent 6 months.
Conclusion: In this large cohort of children, incidental intracranial findings were identified for 6.6%, with potentially serious or urgent findings for 0.6%.
Figures
Source: PubMed