Antifibrinolytic agents in traumatic haemorrhage

Tim Coats, Beverly Hunt, Ian Roberts, Haleema Shakur, Tim Coats, Beverly Hunt, Ian Roberts, Haleema Shakur

Abstract

Among trauma patients who survive to reach hospital, exsanguination is a common cause of death. Could anti fibrinolytics reduce the death rate? Only a large randomized controlled trial can answer the question

Conflict of interest statement

Competing Interests: The authors are the investigators of the CRASH-2 trial but have no other competing interests.

Figures

https://www.ncbi.nlm.nih.gov/pmc/articles/instance/1069662/bin/pmed.0020064.g001.jpg

References

    1. Murray CJL, Lopez AD. Global health statistics: A compendium of incidence, prevalence and mortality estimates for over 200 conditions. Boston: Harvard University Press; 1996. 1010 pp.
    1. Sauaia A, Moore FA, Moore E, Moser K, Brennan R, et al. Epidemiology of trauma deaths: A reassessment. J Trauma. 1995;38:185–193.
    1. The Brain. Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Hypotension. J Neurotrauma. 2000;17(6–7):591–595.
    1. Lawson JH, Murphy MP. Challenges for providing effective hemostasis in surgery and trauma. Semin Hematol. 2004;41:55–64.
    1. Porte RJ, Leebeek FW. Pharmacological strategies to decrease transfusion requirements in patients undergoing surgery. Drugs. 2002;62:2193–2211.
    1. Henry DA, Moxey AJ, Carless PA, O'Connell D, McClelland B, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2004;2004:CD001886.
    1. Coats T, Roberts I, Shakur H. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev. 2004;2004:CD004896.
    1. Aylward GW, Dunlop IS, Little BC. Meta-analysis of systemic antifibrinolytics in traumatic hyphema. Eye. 1994;8:440–442.
    1. Kiwanuka N, Gray RH, Serwadda D, et al. The incidence of HIV-1 associated with injections and transfusions in a prospective cohort, Raki, Uganda. AIDS. 2004;18:342–343.
    1. Heymann SJ, Brewer TF. The problem of transfusion associated acquired immunodeficiency syndrome in Africa: a quantitative approach. Am J Infect Control. 1992;20:256–262.
    1. Goodnough LT, Shander A, Brecher ME. Transfusion medicine: Looking to the future. Lancet. 2003;361:161–169.

Source: PubMed

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