Quality of life in community-dwelling Dutch elderly measured by EQ-5D-3L

Marie-Josée J Mangen, Marieke Bolkenbaas, Susanne M Huijts, Cornelis H van Werkhoven, Marc J M Bonten, G Ardine de Wit, Marie-Josée J Mangen, Marieke Bolkenbaas, Susanne M Huijts, Cornelis H van Werkhoven, Marc J M Bonten, G Ardine de Wit

Abstract

Background: We aimed to evaluate health status and associated factors in community-dwelling elderly in the Netherlands.

Methods: Participants from a placebo-controlled double-blind randomized controlled trial conducted in the Netherlands were invited at the time of enrolment to participate in this study. Data were collected on comorbidities, socio-demographic background and health status, using EQ-5D-3L instrument. EQ-5D-3L summary index values (EQ-5D-indices) was derived using Dutch tariff. Regression analysis was conducted to identify factors associated with EQ-5D-indices and visual analogue scale (EQ-VAS).

Results: 48,634 elderly (≥65 years) were included. The most frequently reported complaint was pain/discomfort (29.4%), but for the elder elderly (i.e. ≥85 years) it was mobility (52.9%). The proportion of persons reporting (multiple) problems increased with age from 31.5% for 65-69 years old subjects to 65.9% for elder elderly. The mean EQ-5D-indices and EQ-VAS decreased with age from 0.94 and 84, respectively in those 65 to 69 years old to 0.86 and 76, respectively, in ≥85 years old subjects. Increasing age, female gender, low education, geographic factors and comorbidities were associated with impaired health status.

Conclusions: Within community-dwelling elderly large differences in health status exist. Impairment increases rapidly with age, but health status is also associated with socio-demographic variables and comorbidities.

Trial registration: ClinicalTrials.gov, NCT00812084 .

Keywords: Community-dwelling; EQ-5D-3L; Elderly; Health status; Health-related quality-of-life; The Netherlands.

Figures

Fig. 1
Fig. 1
Profile of the population: Percentage reporting any problems per domain (a) and percentage reporting number of domains with problems (b) by age-group and sex, respectively. * p ≤ 0.001
Fig. 2
Fig. 2
Mean population EQ-VAS and mean EQ-5D-3L-index by age-group and sex. Note: EQ-VAS and EQ-5D-3L indices were significantly different between age-group and sex (p > 0.01)

References

    1. Statistics Netherlands. Prognose bevolking; geslacht en leeftijd, 2016–2060. Heerlen. Available at: . Accessed on 8 Sept 2016.
    1. Brooks R. EuroQol: the current state of play. Health Policy. 1996;37:53–72. doi: 10.1016/0168-8510(96)00822-6.
    1. Brooks R, Rabin R, de Charro F (Eds). The measurement and valuation of health status using EQ-5D: a European perspective - Evidence from the EuroQol BIOMED Research Programme. Kluwer Academic Publishers, 2003. ISBN 978-94-017-0233-1.
    1. Brazier JE, Walters SJ, Nicholi JP, Kohler B. Using the SF-36 and Euroqol on an elderly population. Qual Life Res. 1996;5:195–204. doi: 10.1007/BF00434741.
    1. Holland R, Smith RD, Harvey I, Swift L, Lenaghan E. Assessing quality of life in the elderly: a direct comparison of the EQ-5D and AQoL. Health Econ. 2004;13:793–805. doi: 10.1002/hec.858.
    1. Stolk E, Krabbe P, Busschbach J. Using the Internet to collect EQ-5D norm scores a valid alternative? In: Busschbach j, Rabin R, De Charro F. (Eds.), 24th Scientific Plenary Meeting of the EuroQol Group - Proceedings:153-1 K5: EuroQol Group, 2009.
    1. Timmers TK, Verhofstad MHJ, Moons KGM, van Beeck EF, Leenen LPH. Long-term quality of life after surgical intensive care admission. Arch Surg. 2011;146(4):412–417. doi: 10.1001/archsurg.2010.279.
    1. Szende A, Janssen B, Cabase’s J. Self-Reported Population Health: An International Perspective based on EQ-5D. Springer Open; 2014. Available at:. Accessed on 9 Aug 2016.
    1. Hoeymans N, van Lindert H, Westert GP. The health status of the Dutch population as assessed by the EQ-6D. Qual Life Res. 2005;14:655–663. doi: 10.1007/s11136-004-1214-z.
    1. König H-H, Heider D, Lehnert T, Riedel-Heller SG, Angermeyer MC, Matschinger H, et al. Health status of the advanced elderly in six European countries: results from a representative survey using EQ-5D and SF-12. Health Qual Life Outcomes. 2010;8:143. doi: 10.1186/1477-7525-8-47.
    1. Versteegh M, Vermeulen M, Evers MAA, de Wit GA, Prenger R, Stolk E. Dutch tariff for the five-level version of EQ-5D. Value Health. 2016;19:343–352. doi: 10.1016/j.jval.2016.01.003.
    1. Alonso J, Angermeyer MC, Bernert S, Bruffaerts R, Brugha TS, Bryson H, et al. Sampling and methods of the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand Suppl. 2004;420:8–20.
    1. Konerding U, Elkhuizen SG, Faubel R, Forte P, Malmstrom T, Pavi E, Janssen MF. The validity of the EQ-5D-3L items: an investigation with type 2 diabetes patients from six European countries. Health Qual Life Outcomes. 2014;12:181. doi: 10.1186/s12955-014-0181-5.
    1. Kontodimopoulos N, Pappa E, Niakas D, Yfantopoulos J, Dimitrakaki C, Tountas Y. Validity of the EuroQoL (EQ-5D) instrument in a Greek general population. Value Health. 2008;11:1162–1169. doi: 10.1111/j.1524-4733.2008.00356.x.
    1. Bernert S, Fernandez A, Haro JM, König HH, Alonso J, Vilagut G, et al. Comparison of different valuation methods for population health status measured by the EQ-5D in three European countries. Value Health. 2009;12:750–758. doi: 10.1111/j.1524-4733.2009.00509.x.
    1. Savoia E, Fantini MP, Pandolfi PP, Dallolio L, Collina N. Assessing the construct validity of the Italian version of the EQ-5D: preliminary results from a cross-sectional study in North Italy. Health Qual Life Outcomes. 2006;4:47. doi: 10.1186/1477-7525-4-47.
    1. Golicki D, Niewada M. General population reference values for 3-level EQ-5D (EQ-5D-3L) questionnaire in Poland. Pol Arch Med Wewn. 2015;125(1–2):18–26.
    1. Kaambwa B, Gill L, McCaffrey N, Lancsar E, Cameron ID, Crotty M, et al. An empirical comparison of the OPQoL-Brief, EQ-5D-3L and ASCOT in a community dwelling population of older people. Health Qual Life Outcomes. 2015;13:164. doi: 10.1186/s12955-015-0357-7.
    1. Perneger TV, Combescure C, Courvoisier DS. General population reference values for the French version of the EuroQol EQ-5D health utility instrument. Value Health. 2010;13(5):631–635. doi: 10.1111/j.1524-4733.2010.00727.x.
    1. Mangen MJJ, Bonten MJM, de Wit GA. Rationale and design of the costs, health status and outcomes in community-acquired pneumonia (CHO-CAP) study in elderly persons hospitalized with CAP. BMC Infect Dis. 2013;13:597. doi: 10.1186/1471-2334-13-597.
    1. Hak E, Grobbee DE, Sanders EA, Verheij TJ, Bolkenbaas M, Huijts SM, et al. Rationale and design of CAPITA: a RCT of 13-valent conjugated pneumococcal vaccine efficacy among older adults. Neth J Med. 2008;66(9):378–83.
    1. Bonten MJM, Huijts SM, Bolkenbaas M, Webber C, Patterson S, Gault S, et al. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med. 2015;372(12):1114–1125. doi: 10.1056/NEJMoa1408544.
    1. Lamers LM, McDonnell J, Stalmeier PF, Krabbe PF, Busschbach JJ. The Dutch tariff: results and arguments for an effective design for national EQ-5D valuation studies. Health Econ. 2006;15(10):1121–1132. doi: 10.1002/hec.1124.
    1. Anonymous. Postcodes en provincies. Retrieved from ; 2015. Accessed on 3 Sept 2015.
    1. Anonymous. First-level NUTS of the European Union. Retrieved from ; 2015. Accessed on 3 Sept 2015.
    1. Clemens S, Begum N, Harper C, Whitty J, Scuffham PA. A comparison of EQ-5D-3L population norms in Queensland, Australia, estimated using utility value sets from Australia, the UK and USA. Qual Life Res. 2014;23:2375–2381. doi: 10.1007/s11136-014-0676-x.
    1. König HH, Bernert S, Angermeyer MC, Matschinger H, Martinez M, Vilagut G, et al. Comparison of population health status in six european countries: results of a representative survey using the EQ-5D questionnaire. Med Care. 2009;47:255–261. doi: 10.1097/MLR.0b013e318184759e.
    1. Anonymous. Goed ervaren gezondheid per GGD-regio. Available at: . Accessed on 10 Sep 2016.
    1. Statistics Netherlands. Kerncijfers postcodegebieden, 2008–2010. Retrieved from , 2015. Accessed on 3 Sept 2015.

Source: PubMed

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