Narrative Review of Hydration and Selected Health Outcomes in the General Population

DeAnn Liska, Eunice Mah, Tristin Brisbois, Pamela L Barrios, Lindsay B Baker, Lawrence L Spriet, DeAnn Liska, Eunice Mah, Tristin Brisbois, Pamela L Barrios, Lindsay B Baker, Lawrence L Spriet

Abstract

Although adequate hydration is essential for health, little attention has been paid to the effects of hydration among the generally healthy population. This narrative review presents the state of the science on the role of hydration in health in the general population, specifically in skin health, neurological function (i.e., cognition, mood, and headache), gastrointestinal and renal functions, and body weight and composition. There is a growing body of evidence that supports the importance of adequate hydration in maintaining proper health, especially with regard to cognition, kidney stone risk, and weight management. However, the evidence is largely associative and lacks consistency, and the number of randomized trials is limited. Additionally, there are major gaps in knowledge related to health outcomes due to small variations in hydration status, the influence of sex and sex hormones, and age, especially in older adults and children.

Keywords: body weight; cognition; constipation; dehydration; fluid; headache; kidney; mood; skin; systematic review; water.

Conflict of interest statement

Authors Tristin Brisbois, Pamela L. Barrios, and Lindsay B. Baker are employed by PepsiCo, Inc. The views expressed in this work are those of the authors and do not necessarily reflect the position or policy of PepsiCo, Inc.

Figures

Figure 1
Figure 1
PRISMA flowchart.

References

    1. European Food Safety Authority (EFSA) Panel on Dietetic Products Nutrition and Allergies (NDA) Scientific Opinion on Dietary Reference Values for water. EFSA J. 2010;8:1459–1507.
    1. Food and Nutrition Board, Institute of Medicine (IOM) Panel on Dietary Reference Intakes for Electrolytes and Water . Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. National Academy of Sciences Press; Washington, DC, USA: 2005.
    1. Cheuvront S.N., Kenefick R.W. Dehydration: Physiology, assessment, and performance effects. Compr. Physiol. 2014;4:257–285.
    1. Thomas D.R., Cote T.R., Lawhorne L., Levenson S.A., Rubenstein L.Z., Smith D.A., Stefanacci R.G., Tangalos E.G., Morley J.E., Dehydration Council Understanding clinical dehydration and its treatment. J. Am. Med. Dir. Assoc. 2008;9:292–301. doi: 10.1016/j.jamda.2008.03.006.
    1. Sawka M.N., Cheuvront S.N., Kenefick R.W. Hypohydration and Human Performance: Impact of Environment and Physiological Mechanisms. Sports Med. 2015;45(Suppl. 1):S51–S60. doi: 10.1007/s40279-015-0395-7.
    1. Bak A., Tsiami A., Greene C. Methods of Assessment of Hydration Status and their Usefulness in Detecting Dehydration in the Elderly. Curr. Res. Nutr. Food Sci. 2017;5:43–54. doi: 10.12944/CRNFSJ.5.2.01.
    1. Cheuvront S.N., Ely B.R., Kenefick R.W., Sawka M.N. Biological variation and diagnostic accuracy of dehydration assessment markers. Am. J. Clin. Nutr. 2010;92:565–573. doi: 10.3945/ajcn.2010.29490.
    1. Cheuvront S.N., Kenefick R.W., Zambraski E.J. Spot Urine Concentrations Should Not be Used for Hydration Assessment: A Methodology Review. Int. J. Sport Nutr. Exerc. Metab. 2015;25:293–297. doi: 10.1123/ijsnem.2014-0138.
    1. Armstrong L.E. Hydration assessment techniques. Nutr. Rev. 2005;63:S40–S54. doi: 10.1111/j.1753-4887.2005.tb00153.x.
    1. Armstrong L.E. Assessing hydration status: The elusive gold standard. J. Am. Coll. Nutr. 2007;26:575S–584S. doi: 10.1080/07315724.2007.10719661.
    1. Cheuvront S.N. Urinalysis for hydration assessment: An age-old problem. Am. J. Clin. Nutr. 2016;104:3–4. doi: 10.3945/ajcn.116.137703.
    1. Fortes M.B., Owen J.A., Raymond-Barker P., Bishop C., Elghenzai S., Oliver S.J., Walsh N.P. Is this elderly patient dehydrated? Diagnostic accuracy of hydration assessment using physical signs, urine, and saliva markers. J. Am. Med. Dir. Assoc. 2015;16:221–228. doi: 10.1016/j.jamda.2014.09.012.
    1. Heavens K.R., Charkoudian N., O’Brien C., Kenefick R.W., Cheuvront S.N. Noninvasive assessment of extracellular and intracellular dehydration in healthy humans using the resistance-reactance-score graph method. Am. J. Clin. Nutr. 2016;103:724–729. doi: 10.3945/ajcn.115.115352.
    1. Hooper L., Bunn D., Jimoh F.O., Fairweather-Tait S.J. Water-loss dehydration and aging. Mech. Ageing Dev. 2014;136–137:50–58. doi: 10.1016/j.mad.2013.11.009.
    1. Hooper L., Bunn D.K., Abdelhamid A., Gillings R., Jennings A., Maas K., Millar S., Twomlow E., Hunter P.R., Shepstone L., et al. Water-loss (intracellular) dehydration assessed using urinary tests: How well do they work? Diagnostic accuracy in older people. Am. J. Clin. Nutr. 2016;104:121–131. doi: 10.3945/ajcn.115.119925.
    1. Volkert D., Beck A.M., Cederholm T., Cruz-Jentoft A., Goisser S., Hooper L., Kiesswetter E., Maggio M., Raynaud-Simon A., Sieber C.C., et al. ESPEN guideline on clinical nutrition and hydration in geriatrics. Clin. Nutr. 2018 doi: 10.1016/j.clnu.2018.05.024.
    1. Warren J., Guelinckx I., Livingstone B., Potischman N., Nelson M., Foster E., Holmes B. Challenges in the assessment of total fluid intake in children and adolescents: A discussion paper. Eur. J. Nutr. 2018;57:43–51. doi: 10.1007/s00394-018-1745-7.
    1. Gandy J. Water intake: Validity of population assessment and recommendations. Eur. J. Nutr. 2015;54(Suppl. 2):11–16. doi: 10.1007/s00394-015-0944-8.
    1. El-Sharkawy A.M., Sahota O., Lobo D.N. Acute and chronic effects of hydration status on health. Nutr. Rev. 2015;73(Suppl. 2):97–109. doi: 10.1093/nutrit/nuv038.
    1. Kenefick R.W., Cheuvront S.N. Hydration for recreational sport and physical activity. Nutr. Rev. 2012;70(Suppl. 2):S137–S142. doi: 10.1111/j.1753-4887.2012.00523.x.
    1. Manz F. Hydration and disease. J. Am. Coll. Nutr. 2013;26:535S–541S. doi: 10.1080/07315724.2007.10719655.
    1. Maughan R.J., Shirreffs S.M. Dehydration and rehydration in competitive sport. Scand. J. Med. Sci. Sports. 2010;20(Suppl. 3):40–47. doi: 10.1111/j.1600-0838.2010.01207.x.
    1. Maughan R.J., Shirreffs S.M. Development of hydration strategies to optimize performance for athletes in high-intensity sports and in sports with repeated intense efforts. Scand. J. Med. Sci. Sports. 2010;20(Suppl. 2):59–69. doi: 10.1111/j.1600-0838.2010.01191.x.
    1. Akdeniz M., Tomova-Simitchieva T., Dobos G., Blume-Peytavi U., Kottner J. Does dietary fluid intake affect skin hydration in healthy humans? A systematic literature review. Skin Res. Technol. 2018;24:459–465. doi: 10.1111/srt.12454.
    1. Benton D., Young H.A. Do small differences in hydration status affect mood and mental performance? Nutr. Rev. 2015;73(Suppl. 2):83–96. doi: 10.1093/nutrit/nuv045.
    1. Masento N.A., Golightly M., Field D.T., Butler L.T., van Reekum C.M. Effects of hydration status on cognitive performance and mood. Br. J. Nutr. 2014;111:1841–1852. doi: 10.1017/S0007114513004455.
    1. Cheungpasitporn W., Rossetti S., Friend K., Erickson S.B., Lieske J.C. Treatment effect, adherence, and safety of high fluid intake for the prevention of incident and recurrent kidney stones: A systematic review and meta-analysis. J. Nephrol. 2016;29:211–219. doi: 10.1007/s40620-015-0210-4.
    1. Boilesen S.N., Tahan S., Dias F.C., Melli L., de Morais M.B. Water and fluid intake in the prevention and treatment of functional constipation in children and adolescents: Is there evidence? J. Pediatr. 2017;93:320–327. doi: 10.1016/j.jped.2017.01.005.
    1. Stookey J.J. Negative, Null and Beneficial Effects of Drinking Water on Energy Intake, Energy Expenditure, Fat Oxidation and Weight Change in Randomized Trials: A Qualitative Review. Nutrients. 2016;8:19. doi: 10.3390/nu8010019.
    1. Dabrowska A.K., Spano F., Derler S., Adlhart C., Spencer N.D., Rossi R.M. The relationship between skin function, barrier properties, and body-dependent factors. Skin Res. Technol. 2018;24:165–174. doi: 10.1111/srt.12424.
    1. Kolarsick P.A.J., Kolarsick M.A., Goodwin C. Anatomy and Physiology of the Skin. J. Dermatol. Nurse Assoc. 2011;3:203–213. doi: 10.1097/JDN.0b013e3182274a98.
    1. Rittie L., Fisher G.J. Natural and sun-induced aging of human skin. Cold Spring Harb. Perspect. Med. 2015;5:a015370. doi: 10.1101/cshperspect.a015370.
    1. Palma L., Marques L.T., Bujan J., Rodrigues L.M. Dietary water affects human skin hydration and biomechanics. Clin. Cosmet. Investig. Dermatol. 2015;8:413–421.
    1. Palma M.L., Monteiro C., Bujan L.T.M.J., Rodrigues L.M. Relationship between the dietary intake of water and skin hydration. Biomed. Biopharm. Res. 2012;9:173–181. doi: 10.19277/BBR.9.2.39.
    1. Palma M.L., Tavares L., Fluhr J.W., Bujan M.J., Rodrigues L.M. Positive impact of dietary water on in vivo epidermal water physiology. Skin Res. Technol. 2015;21:413–418. doi: 10.1111/srt.12208.
    1. Mac-Mary S., Creidi P., Marsaut D., Courderot-Masuyer C., Cochet V., Gharbi T., Guidicelli-Arranz D., Tondu F., Humbert P. Assessment of effects of an additional dietary natural mineral water uptake on skin hydration in healthy subjects by dynamic barrier function measurements and clinic scoring. Skin Res. Technol. 2006;12:199–205. doi: 10.1111/j.0909-752X.2006.00160.x.
    1. Williams S., Krueger N., Davids M., Kraus D., Kerscher M. Effect of fluid intake on skin physiology: Distinct differences between drinking mineral water and tap water. Int. J. Cosmet. Sci. 2007;29:131–138. doi: 10.1111/j.1467-2494.2007.00366.x.
    1. Edmonds C.J., Crosbie L., Fatima F., Hussain M., Jacob N., Gardner M. Dose-response effects of water supplementation on cognitive performance and mood in children and adults. Appetite. 2017;108:464–470. doi: 10.1016/j.appet.2016.11.011.
    1. Trinies V., Chard A.N., Mateo T., Freeman M.C. Effects of Water Provision and Hydration on Cognitive Function among Primary-School Pupils in Zambia: A Randomized Trial. PLoS ONE. 2016;11:e0150071. doi: 10.1371/journal.pone.0150071.
    1. Perry C.S., 3rd, Rapinett G., Glaser N.S., Ghetti S. Hydration status moderates the effects of drinking water on children’s cognitive performance. Appetite. 2015;95:520–527. doi: 10.1016/j.appet.2015.08.006.
    1. Booth P., Edmonds C.J. Water supplementation improves visual attention and fine motor skills in schoolchildren. Educ. Health. 2012;30:75–79.
    1. Fadda R., Rapinett G., Grathwohl D., Parisi M., Fanari R., Calo C.M., Schmitt J. Effects of drinking supplementary water at school on cognitive performance in children. Appetite. 2012;59:730–737. doi: 10.1016/j.appet.2012.07.005.
    1. Kempton M.J., Ettinger U., Foster R., Williams S.C., Calvert G.A., Hampshire A., Zelaya F.O., O’Gorman R.L., McMorris T., Owen A.M., et al. Dehydration affects brain structure and function in healthy adolescents. Hum. Brain Mapp. 2011;32:71–79. doi: 10.1002/hbm.20999.
    1. Edmonds C.J., Jeffes B. Does having a drink help you think? 6–7-Year-old children show improvements in cognitive performance from baseline to test after having a drink of water. Appetite. 2009;53:469–472. doi: 10.1016/j.appet.2009.10.002.
    1. Edmonds C.J., Burford D. Should children drink more water?: The effects of drinking water on cognition in children. Appetite. 2009;52:776–779. doi: 10.1016/j.appet.2009.02.010.
    1. Benton D., Burgess N. The effect of the consumption of water on the memory and attention of children. Appetite. 2009;53:143–146. doi: 10.1016/j.appet.2009.05.006.
    1. Stachenfeld N.S., Leone C.A., Mitchell E.S., Freese E., Harkness L. Water intake reverses dehydration associated impaired executive function in healthy young women. Physiol. Behav. 2018;185:103–111. doi: 10.1016/j.physbeh.2017.12.028.
    1. Benton D., Jenkins K.T., Watkins H.T., Young H.A. Minor degree of hypohydration adversely influences cognition: A mediator analysis. Am. J. Clin. Nutr. 2016;104:603–612. doi: 10.3945/ajcn.116.132605.
    1. Pross N., Demazieres A., Girard N., Barnouin R., Metzger D., Klein A., Perrier E., Guelinckx I. Effects of changes in water intake on mood of high and low drinkers. PLoS ONE. 2014;9:e94754. doi: 10.1371/journal.pone.0094754.
    1. Edmonds C.J., Crombie R., Ballieux H., Gardner M.R., Dawkins L. Water consumption, not expectancies about water consumption, affects cognitive performance in adults. Appetite. 2013;60:148–153. doi: 10.1016/j.appet.2012.10.016.
    1. Lindseth P.D., Lindseth G.N., Petros T.V., Jensen W.C., Caspers J. Effects of hydration on cognitive function of pilots. Mil. Med. 2013;178:792–798. doi: 10.7205/MILMED-D-13-00013.
    1. Edmonds C.J., Crombie R., Gardner M.R. Subjective thirst moderates changes in speed of responding associated with water consumption. Front. Hum. Neurosci. 2013;7:363. doi: 10.3389/fnhum.2013.00363.
    1. Ely B.R., Sollanek K.J., Cheuvront S.N., Lieberman H.R., Kenefick R.W. Hypohydration and acute thermal stress affect mood state but not cognition or dynamic postural balance. Eur. J. Appl. Physiol. 2013;113:1027–1034. doi: 10.1007/s00421-012-2506-6.
    1. Pross N., Demazieres A., Girard N., Barnouin R., Santoro F., Chevillotte E., Klein A., Le Bellego L. Influence of progressive fluid restriction on mood and physiological markers of dehydration in women. Br. J. Nutr. 2013;109:313–321. doi: 10.1017/S0007114512001080.
    1. Armstrong L.E., Ganio M.S., Casa D.J., Lee E.C., McDermott B.P., Klau J.F., Jimenez L., Le Bellego L., Chevillotte E., Lieberman H.R. Mild dehydration affects mood in healthy young women. J. Nutr. 2012;142:382–388. doi: 10.3945/jn.111.142000.
    1. Ganio M.S., Armstrong L.E., Casa D.J., McDermott B.P., Lee E.C., Yamamoto L.M., Marzano S., Lopez R.M., Jimenez L., Le Bellego L., et al. Mild dehydration impairs cognitive performance and mood of men. Br. J. Nutr. 2011;106:1535–1543. doi: 10.1017/S0007114511002005.
    1. Kempton M.J., Ettinger U., Schmechtig A., Winter E.M., Smith L., McMorris T., Wilkinson I.D., Williams S.C., Smith M.S. Effects of acute dehydration on brain morphology in healthy humans. Hum. Brain Mapp. 2009;30:291–298. doi: 10.1002/hbm.20500.
    1. Petri N.M., Dropulic N., Kardum G. Effects of voluntary fluid intake deprivation on mental and psychomotor performance. Croat. Med. J. 2006;47:855–861.
    1. Szinnai G., Schachinger H., Arnaud M.J., Linder L., Keller U. Effect of water deprivation on cognitive-motor performance in healthy men and women. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005;289:R275–R280. doi: 10.1152/ajpregu.00501.2004.
    1. Shirreffs S.M., Merson S.J., Fraser S.M., Archer D.T. The effects of fluid restriction on hydration status and subjective feelings in man. Br. J. Nutr. 2004;91:951–958. doi: 10.1079/BJN20041149.
    1. Neave N., Scholey A.B., Emmett J.R., Moss M., Kennedy D.O., Wesnes K.A. Water ingestion improves subjective alertness, but has no effect on cognitive performance in dehydrated healthy young volunteers. Appetite. 2001;37:255–256. doi: 10.1006/appe.2001.0429.
    1. Rogers P.J., Kainth A., Smit H.J. A drink of water can improve or impair mental performance depending on small differences in thirst. Appetite. 2001;36:57–58. doi: 10.1006/appe.2000.0374.
    1. Gopinathan P.M., Pichan G., Sharma V.M. Role of dehydration in heat stress-induced variations in mental performance. Arch. Environ. Health. 1988;43:15–17. doi: 10.1080/00039896.1988.9934367.
    1. Sharma V.M., Sridharan K., Pichan G., Panwar M.R. Influence of heat-stress induced dehydration on mental functions. Ergonomics. 1986;29:791–799. doi: 10.1080/00140138608968315.
    1. Spigt M., Weerkamp N., Troost J., van Schayck C.P., Knottnerus J.A. A randomized trial on the effects of regular water intake in patients with recurrent headaches. Fam. Pract. 2012;29:370–375. doi: 10.1093/fampra/cmr112.
    1. Spigt M.G., Kuijper E.C., Schayck C.P., Troost J., Knipschild P.G., Linssen V.M., Knottnerus J.A. Increasing the daily water intake for the prophylactic treatment of headache: A pilot trial. Eur. J. Neurol. 2005;12:715–718. doi: 10.1111/j.1468-1331.2005.01081.x.
    1. Alelign T., Petros B. Kidney Stone Disease: An Update on Current Concepts. Adv. Urol. 2018;2018:3068365. doi: 10.1155/2018/3068365.
    1. Dion M., Ankawi G., Chew B., Paterson R., Sultan N., Hoddinott P., Razvi H. CUA guideline on the evaluation and medical management of the kidney stone patient—2016 update. Can. Urol. Assoc. J. 2016;10:E347–E358. doi: 10.5489/cuaj.4218.
    1. Pearle M.S., Goldfarb D.S., Assimos D.G., Curhan G., Denu-Ciocca C.J., Matlaga B.R., Monga M., Penniston K.L., Preminger G.M., Turk T.M., et al. Medical management of kidney stones: AUA guideline. J. Urol. 2014;192:316–324. doi: 10.1016/j.juro.2014.05.006.
    1. Borghi L., Meschi T., Amato F., Briganti A., Novarini A., Giannini A. Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: A 5-year randomized prospective study. J. Urol. 1996;155:839–843. doi: 10.1016/S0022-5347(01)66321-3.
    1. Sarica K., Inal Y., Erturhan S., Yagci F. The effect of calcium channel blockers on stone regrowth and recurrence after shock wave lithotripsy. Urol. Res. 2006;34:184–189. doi: 10.1007/s00240-006-0040-x.
    1. Leiper J.B. Fate of ingested fluids: Factors affecting gastric emptying and intestinal absorption of beverages in humans. Nutr. Rev. 2015;73(Suppl. 2):57–72. doi: 10.1093/nutrit/nuv032.
    1. Anti M., Pignataro G., Armuzzi A., Valenti A., Iascone E., Marmo R., Lamazza A., Pretaroli A.R., Pace V., Leo P., et al. Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional constipation. Hepatogastroenterology. 1998;45:727–732.
    1. Klauser A.G., Beck A., Schindlbeck N.E., Muller-Lissner S.A. Low fluid intake lowers stool output in healthy male volunteers. Z. Gastroenterol. 1990;28:606–609.
    1. Chung B.D., Parekh U., Sellin J.H. Effect of increased fluid intake on stool output in normal healthy volunteers. J. Clin. Gastroenterol. 1999;28:29–32. doi: 10.1097/00004836-199901000-00006.
    1. Ziegenhagen D.J., Tewinkel G., Kruis W., Herrmann F. Adding more fluid to wheat bran has no significant effects on intestinal functions of healthy subjects. J. Clin. Gastroenterol. 1991;13:525–530. doi: 10.1097/00004836-199110000-00010.
    1. van Nieuwenhoven M.A., Vriens B.E., Brummer R.J., Brouns F. Effect of dehydration on gastrointestinal function at rest and during exercise in humans. Eur. J. Appl. Physiol. 2000;83:578–584. doi: 10.1007/s004210000305.
    1. Akers J.D., Cornett R.A., Savla J.S., Davy K.P., Davy B.M. Daily self-monitoring of body weight, step count, fruit/vegetable intake, and water consumption: A feasible and effective long-term weight loss maintenance approach. J. Acad. Nutr. Diet. 2012;112:685–692.e2. doi: 10.1016/j.jand.2012.01.022.
    1. Dennis E.A., Dengo A.L., Comber D.L., Flack K.D., Savla J., Davy K.P., Davy B.M. Water consumption increases weight loss during a hypocaloric diet intervention in middle-aged and older adults. Obesity. 2010;18:300–307. doi: 10.1038/oby.2009.235.
    1. Muckelbauer R., Libuda L., Clausen K., Toschke A.M., Reinehr T., Kersting M. Promotion and provision of drinking water in schools for overweight prevention: Randomized, controlled cluster trial. Pediatrics. 2009;123:e661–e667. doi: 10.1542/peds.2008-2186.
    1. Stookey J.D., Del Toro R., Hamer J., Medina A., Higa A., Ng V., TinajeroDeck L., Juarez L. Qualitative and/or quantitative drinking water recommendations for pediatric obesity treatment. J. Obes. Weight Loss Ther. 2014;4:232. doi: 10.4172/2165-7904.1000232.
    1. Hernandez-Cordero S., Popkin B.M. Impact of a Water Intervention on Sugar-Sweetened Beverage Intake Substitution by Water: A Clinical Trial in Overweight and Obese Mexican Women. Ann. Nutr. Metab. 2015;66(Suppl. 3):22–25. doi: 10.1159/000381242.
    1. Hernandez-Cordero S., Barquera S., Rodriguez-Ramirez S., Villanueva-Borbolla M.A., Gonzalez de Cossio T., Dommarco J.R., Popkin B. Substituting water for sugar-sweetened beverages reduces circulating triglycerides and the prevalence of metabolic syndrome in obese but not in overweight Mexican women in a randomized controlled trial. J. Nutr. 2014;144:1742–1752. doi: 10.3945/jn.114.193490.
    1. Corney R.A., Horina A., Sunderland C., James L.J. Effect of hydration status and fluid availability on ad-libitum energy intake of a semi-solid breakfast. Appetite. 2015;91:399–404. doi: 10.1016/j.appet.2015.04.075.
    1. Parretti H.M., Aveyard P., Blannin A., Clifford S.J., Coleman S.J., Roalfe A., Daley A.J. Efficacy of water preloading before main meals as a strategy for weight loss in primary care patients with obesity: RCT. Obesity. 2015;23:1785–1791. doi: 10.1002/oby.21167.
    1. Wong J.M.W., Ebbeling C.B., Robinson L., Feldman H.A., Ludwig D.S. Effects of Advice to Drink 8 Cups of Water per Day in Adolescents With Overweight or Obesity: A Randomized Clinical Trial. JAMA Pediatr. 2017;171:e170012. doi: 10.1001/jamapediatrics.2017.0012.
    1. Chang T., Ravi N., Plegue M.A., Sonneville K.R., Davis M.M. Inadequate Hydration, BMI, and Obesity Among US Adults: NHANES 2009–2012. Ann. Fam. Med. 2016;14:320–324. doi: 10.1370/afm.1951.
    1. Kenney E.L., Long M.W., Cradock A.L., Gortmaker S.L. Prevalence of Inadequate Hydration among US Children and Disparities by Gender and Race/Ethnicity: National Health and Nutrition Examination Survey, 2009–2012. Am. J. Public Health. 2015;105:e113–e118. doi: 10.2105/AJPH.2015.302572.
    1. Silva C.L., Topgaard D., Kocherbitov V., Sousa J.J., Pais A.A., Sparr E. Stratum corneum hydration: Phase transformations and mobility in stratum corneum, extracted lipids and isolated corneocytes. Biochim. Biophys. Acta. 2007;1768:2647–2659. doi: 10.1016/j.bbamem.2007.05.028.
    1. Wittbrodt M.T., Millard-Stafford M. Dehydration Impairs Cognitive Performance: A Meta-analysis. Med. Sci. Sports Exerc. 2018;50:2360–2368. doi: 10.1249/MSS.0000000000001682.
    1. Cunningham P., Noble H., Al-Modhefer A.K., Walsh I. Kidney stones: Pathophysiology, diagnosis and management. Br. J. Nurs. 2016;25:1112–1116. doi: 10.12968/bjon.2016.25.20.1112.
    1. Masereeuw R., Russel F.G. Mechanisms and clinical implications of renal drug excretion. Drug Metab. Rev. 2001;33:299–351. doi: 10.1081/DMR-120000654.
    1. Klein A.V., Kiat H. Detox diets for toxin elimination and weight management: A critical review of the evidence. J. Hum. Nutr. Diet. 2015;28:675–686. doi: 10.1111/jhn.12286.
    1. Khan L. Constipation Management in Pediatric Primary Care. Pediatr. Ann. 2018;47:e180–e184. doi: 10.3928/19382359-20180426-02.
    1. Sharma A., Rao S. Constipation: Pathophysiology and Current Therapeutic Approaches. Handb. Exp. Pharmacol. 2017;239:59–74.
    1. Thornton S.N. Increased Hydration Can Be Associated with Weight Loss. Front. Nutr. 2016;3:18. doi: 10.3389/fnut.2016.00018.
    1. Drewnowski A., Rehm C.D., Constant F. Water and beverage consumption among adults in the United States: Cross-sectional study using data from NHANES 2005-2010. BMC Public Health. 2013;13:1068. doi: 10.1186/1471-2458-13-1068.
    1. Stachenfeld N.S. Sex hormone effects on body fluid regulation. Exerc. Sport Sci. Rev. 2008;36:152–159. doi: 10.1097/JES.0b013e31817be928.
    1. Stachenfeld N.S. Hormonal changes during menopause and the impact on fluid regulation. Reprod. Sci. 2014;21:555–561. doi: 10.1177/1933719113518992.
    1. Stookey J.D. High prevalence of plasma hypertonicity among community-dwelling older adults: Results from NHANES III. J. Am. Diet. Assoc. 2005;105:1231–1239. doi: 10.1016/j.jada.2005.05.003.
    1. Maughan R.J. Hydration, morbidity, and mortality in vulnerable populations. Nutr. Rev. 2012;70(Suppl. 2):S152–S155. doi: 10.1111/j.1753-4887.2012.00531.x.
    1. Stotts N.A., Hopf H.W. The link between tissue oxygen and hydration in nursing home residents with pressure ulcers: Preliminary data. J. Wound Ostomy Cont. Nurs. 2003;30:184–190. doi: 10.1097/00152192-200307000-00005.

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