The Effect of Evening Primrose Oil Capsule on Hot Flashes and Night Sweats in Postmenopausal Women: A Single-Blind Randomized Controlled Trial

Farideh Kazemi, Seyedeh Zahra Masoumi, Arezoo Shayan, Khodayar Oshvandi, Farideh Kazemi, Seyedeh Zahra Masoumi, Arezoo Shayan, Khodayar Oshvandi

Abstract

Objectives: Menopause is associated with complications that could decline women's health during this period. Therefore, some of its complications, such as hot flashes and night sweats, must be treated or alleviated.

Methods: This randomized controlled trial included postmenopausal women who were referred to health centers in Hamadan from May 2018 to April 2019. The hot flash and night sweat questionnaires were completed by the researcher a week before and 8 weeks after the intervention. The intervention group took one capsule (1,000 mg) of evening primrose oil twice daily, while the control group received the same amount of placebo. Finally, the results were analyzed using Stata 13.

Results: The mean scores of duration, frequency, and severity of hot flashes did not significantly decrease in both groups after the intervention compared with before the intervention, and no statistically significant difference was observed (P > 0.05). However, the intervention group had lower frequency and severity of night sweats after the intervention than the control group, with statistically significant differences (P < 0.05).

Conclusion: Evening primrose oil effectively decreased the frequency and severity of night sweats.

Keywords: Evening primrose oil; Hot flashes; Postmenopause; Sweat.

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Copyright © 2021 by The Korean Society of Menopause.

Figures

Fig. 1. The process of selecting samples.
Fig. 1. The process of selecting samples.

References

    1. Rodríguez-Fuentes G, de Oliveira IM, Ogando-Berea H, Otero-Gargamala MD. An observational study on the effects of Pilates on quality of life in women during menopause. Eur J Integr Med. 2014;6:631–636.
    1. Hess R, Thurston RC, Hays RD, Chang CC, Dillon SN, Ness RB, et al. The impact of menopause on health-related quality of life: results from the STRIDE longitudinal study. Qual Life Res. 2012;21:535–544.
    1. Shayan A, Masoumi SZ, Shobeiri F, Tohidi S, Khalili A. Comparing the effects of Agnugol and metformin on oligomenorrhea in patients with Polycystic Ovary Syndrome: a randomized clinical trial. J Clin Diagn Res. 2016;10:QC13–QC16.
    1. Taylor HS, Pal L, Sell E. Speroff's clinical gynecologic endocrinology and infertility. Philadelphia: Lippincott Williams & Wilkins; 2019.
    1. Ghazanfarpour M, Sadeghi R, Abdolahian S, Latifnejad Roudsari R. The efficacy of Iranian herbal medicines in alleviating hot flashes: a systematic review. Int J Reprod Biomed. 2016;14:155–166.
    1. Messina M. Soy foods, isoflavones, and the health of postmenopausal women. Am J Clin Nutr. 2014;100 Suppl 1:423S–430S.
    1. Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014;4:177.
    1. Estrada-Camarena E, López-Rubalcava C, Valdés-Sustaita B, Azpilcueta-Morales GS, González-Trujano EM. Use of phytoestrogens for the treatment of psychiatric symptoms associated with menopause transition. In: Rodriguez-Landa JF, Cueto-Escobedo J, editors. A multidisciplinary look at menopause. IntechOpen; 2017. pp. 81–109.
    1. Montserrat-de la Paz S, Fernández-Arche MA, Ángel-Martín M, García-Giménez MD. Phytochemical characterization of potential nutraceutical ingredients from Evening Primrose oil (Oenothera biennis L.) Phytochem Lett. 2014;8:158–162.
    1. Shobeiri F, Masoumi SZ, Nikravesh A, Heidari Moghadam R, Karami M. The impact of aerobic exercise on quality of life in women with breast cancer: a randomized controlled trial. J Res Health Sci. 2016;16:127–132.
    1. Sadeghi A, Bakhshi M, Behboodi Z, Goodarzi S, Haghani H. Effect of sage extract on hot flashes in postmenopausal women. CMJA. 2013;2:324–335.
    1. Nahidi F, Zare E, Mojab F, Alavi-Majd H. Effects of licorice on relief and recurrence of menopausal hot flashes. Iran J Pharm Res. 2012;11:541–548.
    1. Newton KM, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med. 2006;145:869–879.
    1. Jassim GA. Strategies for managing hot flashes. J Fam Pract. 2011;60:333–339.
    1. Akbari TN, Davoodabadi FM. Comparative effects of flaxseed, soy on menopausal hot flashes. CMJA. 2012;5:52–60.
    1. Farzaneh F, Fatehi S, Sohrabi MR, Alizadeh K. The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. Arch Gynecol Obstet. 2013;288:1075–1079.
    1. Motaghi Dastenaie B, Safdari F, Raisi Z, Karimian Z. The effect of evening primrose plant on physical symptoms of menopause. JBUMS. 2017;19:34–40.
    1. Mehrpooya M, Rabiee S, Larki-Harchegani A, Fallahian AM, Moradi A, Ataei S, et al. A comparative study on the effect of “black cohosh” and “evening primrose oil” on menopausal hot flashes. J Educ Health Promot. 2018;7:36.
    1. Low Dog T. Menopause: a review of botanical dietary supplements. Am J Med. 2005;118 Suppl 12B:98–108.
    1. Yousefi Z, Abdollahpour N, Ghazanfarpour M, Sadeghi R, Pourmoghadam N. Impacts of herbal medicines on hot flash: a systematic review. J Med Plants. 2016;15:40–46.
    1. Mahboubi M. Evening primrose (Oenothera biennis) oil in management of female ailments. J Menopausal Med. 2019;25:74–82.
    1. Masoumi Z, Keramat A, Hajiaghaee R. Systematic review on effect of herbal medicine on pain after perineal episiotomy and cesarean cutting. J Med Plants. 2011;10:1–16.

Source: PubMed

Patrocinadores y Colaboradores

Condiciones médicas

Intervenciones de drogas

3
Suscribir