Pediatric DXA: technique and interpretation

Larry A Binkovitz, Maria J Henwood, Larry A Binkovitz, Maria J Henwood

Abstract

This article reviews dual X-ray absorptiometry (DXA) technique and interpretation with emphasis on the considerations unique to pediatrics. Specifically, the use of DXA in children requires the radiologist to be a "clinical pathologist" monitoring the technical aspects of the DXA acquisition, a "statistician" knowledgeable in the concepts of Z-scores and least significant changes, and a "bone specialist" providing the referring clinician a meaningful context for the numeric result generated by DXA. The patient factors that most significantly influence bone mineral density are discussed and are reviewed with respect to available normative databases. The effects the growing skeleton has on the DXA result are also presented. Most important, the need for the radiologist to be actively involved in the technical and interpretive aspects of DXA is stressed. Finally, the diagnosis of osteoporosis should not be made on DXA results alone but should take into account other patient factors.

Figures

Fig. 1
Fig. 1
For two bones of known BMD=1g/cm2, the DXA-derived areal BMD will be higher in the larger bone because of the lack of accounting for the true volume of the measured bone. It should be noted that the larger cube will be stronger than the smaller cube (adapted from Carter et al. [5], with permission)
Fig. 2
Fig. 2
DXA images. a AP image of the lumbar spine shows regions of interest from L1 to L4. The bone area and mineral content are used to derive the bone mineral density at each level. The areal density is based on the bone area; the depth dimension is not directly assessed with DXA. Note transitional lumbosacral vertebral body. b AP image of the lumbar spine shows regions of interest from L1 to L4. AP DXA image of the left hip shows regions of interest of the femoral neck, greater trochanter, and total hip. c Total body scan with sub-regions of interests for trunk, extremities, and head
Fig. 3
Fig. 3
Lateral thoracic and lumbar spine image from DXA study for vertebral morphology. Note compressive deformities at T-7 and T-9, and a Schmorl’s node at L1, with otherwise normal vertebral morphology of the lumbar spine

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Source: PubMed

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