The usefulness of xuefu zhuyu tang for patients with angina pectoris: a meta-analysis and systematic review

Guo-Zhong Yi, Yu-Qin Qiu, Ya Xiao, Li-Xia Yuan, Guo-Zhong Yi, Yu-Qin Qiu, Ya Xiao, Li-Xia Yuan

Abstract

Objective. To evaluate the efficacy of Xuefu Zhuyu Tang (XFZYT) for treating angina pectoris (AP). Methods. Six databases were searched (up to December, 2013). Eligible randomized controlled trials (RCTs) evaluating the efficiency of XFZYT plus traditional antianginal medications (TAMs) compared with TAMs alone in patients with AP were included. The outcomes were relief of anginal symptoms (RAS) and improvement of electrocardiogram (ECG) and blood high-density lipoprotein cholesterol (HDL-C) level. Result. Finally 14 RCTs were included. There were evidences that XFZYT combined with TAMs was more effective in improving RAS (RR = 1.29; 95% CI = [1.20, 1.38]), ECG (RR = 1.37; 95% CI = [1.22, 1.54]), and blood HDL-C level (MD = 0.29 mmol/L; 95% CI = [0.23, 0.35]) compared with TAMs alone. Our meta-analysis also showed the pooled number needed to treat (NNT) of the group with stable angina pectoris (SAP) was smaller in improving RAS (4.2 versus 5.7) and ECG (3.1 versus 5.5) compared with the group with both SAP and unstable angina pectoris (UAP). Conclusion. Combination therapy with XFZYT and TAMs is more effective in treating AP compared with TAMs alone. And XFZYT may be a more suitable choice for the treatment of SAP. However, the findings should be interpreted with caution due to the mediocre methodological quality of the included RCTs.

Figures

Figure 1
Figure 1
The flow diagram of study selection process.
Figure 2
Figure 2
Forest plot of trials comparing XFZYT plus TAMs with TAMs, outcome = RAS.
Figure 3
Figure 3
Forest plot of trials comparing XFZYT plus TAMs with TAMs, outcome = ECG.
Figure 4
Figure 4
Forest plot of trials comparing XFZYT plus TAMs with TAMs, outcome = blood HDL-C level (mmol/L).
Figure 5
Figure 5
Forest plot of trials comparing XFZYT plus TAMs with TAMs, outcome = blood LDL-C level (mmol/L).
Figure 6
Figure 6
Forest plot of trials comparing XFZYT plus TAMs with TAMs, outcome = blood TG level (mmol/L).
Figure 7
Figure 7
Forest plot of trials comparing XFZYT plus TAMs with TAMs, outcome = blood TC level (mmol/L).
Figure 8
Figure 8
Funnel plot of trials comparing XFZYT plus TAMs with TAMs, outcome = RAS.

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