Oral and general health-related quality of life in patients treated for oral cancer compared to control group

Rocío Barrios, Manuel Bravo, Jose Antonio Gil-Montoya, Ildefonso Martínez-Lara, Blas García-Medina, Georgios Tsakos, Rocío Barrios, Manuel Bravo, Jose Antonio Gil-Montoya, Ildefonso Martínez-Lara, Blas García-Medina, Georgios Tsakos

Abstract

Background: Health-related quality of life (HRQoL) is gaining importance as a valuable outcome measure in oral cancer area. The aim of this study was to assess the general and oral HRQoL of oral and oropharyngeal cancer patients 6 or more months after treatment and compare them with a population free from this disease.

Methods: A cross-sectional study was carried out with patients treated for oral cancer at least 6 months post-treatment and a gender and age group matched control group. HRQoL was measured with the 12-Item Short Form Health Survey (SF-12); oral HRQoL (OHRQoL) was evaluated using the Oral Health Impact Profile (OHIP-14) and the Oral Impacts on Daily Performances (OIDP). Multivariable regression models assessed the association between the outcomes (SF-12, OHIP-14 and OIDP) and the exposure (patients versus controls), adjusting for sex, age, social class, functional tooth units and presence of illness.

Results: For patients (n = 142) and controls (n = 142), 64.1% were males. The mean age was 65.2 (standard deviation (sd): 12.9) years in patients and 67.5 (sd: 13.7) years in controls. Patients had worse SF-12 Physical Component Summary scores than controls even in fully the adjusted model [β-coefficient = -0.11 (95% CI: -5.12-(-0.16)]. The differences in SF-12 Mental Component Summary were not statistically significant. Regarding OHRQoL patients had 11.63 (95% CI: 6.77-20.01) higher odds for the OHIP-14 and 21.26 (95% CI: 11.54-39.13) higher odds for OIDP of being in a worse category of OHRQoL compared to controls in the fully adjusted model.

Conclusion: At least 6 months after treatment, oral cancer patients had worse OHRQoL, worse physical HRQoL and similar psychological HRQoL than the general population.

References

    1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29. doi: 10.3322/caac.21208.
    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90. doi: 10.3322/caac.20107.
    1. Rogers SN. Quality of life perspectives in patients with oral cancer. Oral Oncol. 2010;46:445–7. doi: 10.1016/j.oraloncology.2010.02.021.
    1. Torres-Carranza E, Infante-Cossío P, Hernández-Guisado JM, Hens-Aumente E, Gutierrez-Pérez JL. Assessment of quality of life in oral cancer. Med Oral Pat Oral Cir Bucal. 2008;13:735–41.
    1. D’Antonio LL, Zimmerman GJ, Cella DF, Long SA. Quality of life and functional status measures in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg. 1996;122:482–7. doi: 10.1001/archotol.1996.01890170018005.
    1. Sischo L, Broder HL. Oral health-related quality of life: what, why, how, and future implications. J Dent Res. 2011;90:1264–70. doi: 10.1177/0022034511399918.
    1. Sherman AC, Simonton S. Advances in quality of life research among head and neck cancer patients. Curr Oncol Rep. 2010;12:208–15. doi: 10.1007/s11912-010-0092-5.
    1. Fang FM, Tsai WL, Chien CY, Chiu HC, Wang CJ. Health-related quality of life outcome for oral cancer survivors after surgery and postoperative radiotherapy. Jpn J Clin. 2004;34:641–6. doi: 10.1093/jjco/hyh118.
    1. Hassel AJ, Danner D, Freier K, Hofele C, Becker-Bikowski K, Engel M. Oral health-related quality of life and depression/anxiety in long-term recurrence-free patients after treatment for advanced oral squamous cell cancer. J Craniomaxillofac Surg. 2012;40:99–102. doi: 10.1016/j.jcms.2011.05.011.
    1. Herce J, Rollón A, Polo J. Quality of life in long-term oral cancer survivors and comparison with reference values of Spanish people. Med Clin (Barc) 2007;128:692–6. doi: 10.1157/13102351.
    1. Llewellyn CD, Weinman J, McGurk M. A cross-sectional comparison study of cognitive and emotional well-being in oral cancer patients. Oral Oncol. 2008;44:124–32. doi: 10.1016/j.oraloncology.2007.01.009.
    1. Herce J, Rollón A, Lozano R, Salazar C, Gallana S. Quality of life in long-term oral cancer survivors: a comparison with Spanish general population norms. J Oral Maxillofac Surg. 2009;67:1607–14. doi: 10.1016/j.joms.2008.12.039.
    1. Herce-Lopez J, Rollon-Mayordomo A, Lozano-Rosado R, Infante-Cossio P, Salazar-Fernandez CI. Assesment of quality of life of oral cancer survivors compared with Spanish population norms. Int J Oral Maxillofac Surg. 2013;42:446–52. doi: 10.1016/j.ijom.2012.11.014.
    1. Cohen J. Statistical power analysis for the behavioural sciences. 2. New Jersey: Lawrence Erlbaum; 1988.
    1. Hatch JP, Shinkai RS, Sakai S, Rugh JD, Paunovich ED. Determinants of masticatory performance in dentate adults. Arch Oral Biol. 2001;46:641–8. doi: 10.1016/S0003-9969(01)00023-1.
    1. Schmidt S, Vilagut G, Garin O, Cunillera O, Tresserras R, Brugulat P, Mompart A, Medina A, Ferrer M, Alonso J. Reference guidelines for the 12-item short-form health survey version 2 based on the catalan general population. Med Clin (Barc) 2012;139:613–25. doi: 10.1016/j.medcli.2011.10.024.
    1. Brazier JE, Roberts J. The estimation of a preference-based measure of health from the SF-12. Med Care. 2004;42:851–9. doi: 10.1097/01.mlr.0000135827.18610.0d.
    1. Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB, Brazier JE, Bullinger M, Kaasa S, Leplege A, Prieto L, Sullivan M. Cross-validation of item selection and scoring for the SF-12 health survey in nine countries: results from the IQOLA project. international quality of life assessment. J Clin Epidemiol. 1998;51:1171–8. doi: 10.1016/S0895-4356(98)00109-7.
    1. Ware JE, Kosinski M, Jr, Turner-Bowker DM, Gandek B. How to score version 2 of the SF 12 health survey (with a supplement documenting version 1) Lincoln, RI: QualityMetric, Inc.; 2002.
    1. Montero-Martín J, Bravo-Pérez M, Albaladejo-Martínez A, Hernández-Martín LA, Rosel-Gallardo EM. Validation the Oral Health Impact Profile (OHIP-14sp) for adults in Spain. Med Oral Patol Oral Cir Bucal. 2009;14:44–50.
    1. Montero J, Bravo M, Albaladejo A. Validation of two complementary oral-health related quality of life indicators (OIDP and OSS 0–10) in two qualitatively distinct samples of the Spanish population. Health Qual Life Outcomes. 2008;6:101. doi: 10.1186/1477-7525-6-101.
    1. Gherunpong S, Tsakos G, Sheiham A. The prevalence and severity of oral impacts on daily performances in Thai primary school children. Health Qual Life Outcomes. 2004;2:57. doi: 10.1186/1477-7525-2-57.
    1. Viechtbauer W. Approximate confidence intervals for standardized effect sizes in the two-independent and two-dependent samples design. J Educ Behav Stat. 2007;32:39–60. doi: 10.3102/1076998606298034.
    1. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. STROBE initiative the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344–9. doi: 10.1016/j.jclinepi.2007.11.008.
    1. Grignon LM, Jameson MJ, Karnell LH, Christensen AJ, Funk GF. General health measures and long-term survival in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg. 2007;133:471–6. doi: 10.1001/archotol.133.5.471.
    1. Sammut L, Ward M, Patel N. Physical activity and quality of life in head and neck cancer survivors: a literature review. Int J Sport Med. 2014;35:794–9. doi: 10.1055/s-0033-1363984.
    1. Allen PF. Assessment of oral health related quality of life. Health Qual Life Outcomes. 2003;8:1–40.
    1. Handschel J, Naujoks C, Kübler NR, Krüskemper G. Fear of recurrence significantly influences quality of life in oral cancer patients. Oral Oncol. 2012;48:1276–80. doi: 10.1016/j.oraloncology.2012.06.015.
    1. Hassanein KA, Musgrove BT, Bradbury E. Functional status of patients with oral cancer and its relation to style of coping, social support and psychological status. Br J Oral Maxillofac Surg. 2011;39:340–5. doi: 10.1054/bjom.2001.0652.
    1. Linsen S, Schmidt-Beer U, Fimmers R, Gruner M, Koeck B. Craniomandibular pain, bite force, and oral health-related quality of life in patients with jaw resection. J Pain Symptom Manage. 2009;37:94–106. doi: 10.1016/j.jpainsymman.2006.12.019.
    1. Biazevic MG, Antunes JL, Togni J, de Andrade FP, de Carvalho MB, Wünsch-Filho V. Survival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection. J Appl Oral Sci. 2010;18:279–84. doi: 10.1590/S1678-77572010000300015.
    1. Dwivedi RC, Chisholm EJ, Khan AS, Harris NJ, Bhide SA, St Rose S, Kerawala CJ, Clarke PM, Nutting CM, Rhys-Evans PH, Harrington KJ, Kazi R. An exploratory study of the influence of clinical-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery. Eur Arch Otorhinolaryngol. 2012;269:1233–9. doi: 10.1007/s00405-011-1756-y.
    1. Schuster M, Stelzle F. Outcome measurements after oral cancer treatment: speech-related aspects—an overview. Oral Maxillofac Surg. 2012;16:291–8. doi: 10.1007/s10006-012-0340-y.
    1. Cnossen IC, van Uden-Kraan CF, Rinkel R, Aalders IJ, de Goede C, de Bree R, Doornaert P, Rietveld DH, Langendijk JA, Witte BI, Leemans CR, Verdonck-de Leeuw IM. Multimodal guided self-help exercise program to prevent speech, swallowing, and shoulder problems among head and neck cancer patients: a feasibility study. J Med Internet Res. 2014;16:e74. doi: 10.2196/jmir.2990.
    1. Zhen Y, Wang JG, Tao D, Wang HJ, Chen WL. Efficacy survey of swallowing function and quality of life in response to therapeutic intervention following rehabilitation treatment in dysphagic tongue cancer patients. Eur J Oncol Nurs. 2012;16:54–8. doi: 10.1016/j.ejon.2011.03.002.
    1. Guru K, Manoor UK, Supe SS. A comprehensive review of head and neck cancer rehabilitation: physical therapy perspectives. Indian J Palliat Care. 2012;18:87–97. doi: 10.4103/0973-1075.100820.
    1. Infante-Cossio P, Torres-Carranza E, Cayuela A, Hens-Aumente E, Pastor-Gaitan P, Gutierrez-Perez JL. Impact of treatment on quality of life for oral and oropharyngeal carcinoma. Int J Oral Maxillofac Surg. 2009;38:1052–8. doi: 10.1016/j.ijom.2009.06.008.
    1. Gurney TA, Eisele DW, Orloff LA, Wang SF. Predictors of quality of life after treatment for oral cavity and oropharyngeal carcinoma. Otolaryngol Head Neck Surg. 2008;139:262–7. doi: 10.1016/j.otohns.2008.05.024.
    1. Chandu A, Smith AC, Rogers SN. Health-related quality of life in oral cancer: a review. J Oral Maxillofac Surg. 2006;64:495–502. doi: 10.1016/j.joms.2005.11.028.
    1. Barrios R, Montero J, González-Moles MA, Baca P, Bravo M. Levels of scientific evidence of the quality of life in patients treated for oral cancer. Med Oral Patol Oral Cir Bucal. 2013;18:e578–84. doi: 10.4317/medoral.19052.

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